Search Results - "Jang, I J"

Selective enhancement of optical nonlinearity in two-dimensional organic-inorganic lead iodide perovskites by Saouma, F. O., Stoumpos, C. C., Wong, J., Kanatzidis, M. G., Jang, J. I.

“…Reducing the dimensionality of three-dimensional hybrid metal halide perovskites can improve their optoelectronic properties. Here, we show that the…”
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Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium‐competitive acid blocker, in healthy male subjects by Sunwoo, J., Oh, J., Moon, S. J., Ji, S. C., Lee, S. H., Yu, K.‐S., Kim, H. S., Lee, A., Jang, I.‐J.

“…Summary Background A novel potassium‐competitive acid blocker, DWP14012, is in clinical development as a potential alternative to proton pump inhibitors for…”
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Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance by Shin, K-H, Choi, M H, Lim, K S, Yu, K-S, Jang, I-J, Cho, J-Y

“…This study aimed to evaluate endogenous metabolic markers of hepatic cytochrome P450 (CYP)3A activity in healthy subjects using a metabolomics approach…”
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Targeted Next‐Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes by Han, SM, Park, J, Lee, JH, Lee, SS, Kim, H, Han, H, Kim, Y, Yi, S, Cho, J‐Y, Jang, I‐J, Lee, MG

“…Phenotypic differences in drug responses have been associated with known pharmacogenomic loci, but many remain to be characterized. Therefore, we developed…”
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Inhibition of the multidrug and toxin extrusion (MATE) transporter by pyrimethamine increases the plasma concentration of metformin but does not increase antihyperglycaemic activity in humans by Oh, J., Chung, H., Park, S.-I., Yi, S. J., Jang, K., Kim, A. H., Yoon, J., Cho, J.-Y., Yoon, S. H., Jang, I.-J., Yu, K.-S., Chung, J.-Y.

“…We hypothesized that the pharmacodynamic (PD) characteristics of metformin would change with inhibition of the multidrug and toxin extrusion (MATE)…”
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Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects by Lee, S., Kim, B.-H., Lim, K., Stalker, D., Wisemandle, W., Shin, S.-G., Jang, I.-J., Yu, K.-S.

“…Summary What is known and Objective:  Dexmedetomidine is a selective alpha2‐adrenoreceptor agonist used for sedation in critically ill patients. The current…”
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Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations by Myrand, SP, Sekiguchi, K, Man, MZ, Lin, X, Tzeng, R‐Y, Teng, C‐H, Hee, B, Garrett, M, Kikkawa, H, Lin, C‐Y, Eddy, SM, Dostalik, J, Mount, J, Azuma, J, Fujio, Y, Jang, I‐J, Shin, S‐G, Bleavins, MR, Williams, JA, Paulauskis, JD, Wilner, KD

“…Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors…”
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A novel K+ competitive acid blocker, YH4808, sustains inhibition of gastric acid secretion with a faster onset than esomeprazole: randomised clinical study in healthy volunteers by Yi, S., Lee, H., Jang, S. B., Byun, H. M., Yoon, S. H., Cho, J.‐Y., Jang, I.‐J., Yu, K.‐S.

“…Summary Background YH4808, a K+‐competitive acid blocker, is under clinical development for the treatment of acid‐related disorders, such as gastroesophageal…”
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Near bandgap second-order nonlinear optical characteristics of MoS2 monolayer transferred on transparent substrates by Clark, D. J., Le, C. T., Senthilkumar, V., Ullah, F., Cho, H.-Y., Sim, Y., Seong, M.-J., Chung, K.-H., Kim, Y. S., Jang, J. I.

“…We have investigated the second-order nonlinear optical (NLO) properties of CVD-grown MoS2 monolayer (ML) transferred onto transparent substrates such as fused…”
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Aspirin Decreases Systemic Exposure to Clopidogrel Through Modulation of P-Glycoprotein But Does Not Alter Its Antithrombotic Activity by Oh, J, Shin, D, Lim, K S, Lee, S, Jung, K-H, Chu, K, Hong, K S, Shin, K-H, Cho, J-Y, Yoon, S H, Ji, S C, Yu, K-S, Lee, H, Jang, I-J

“…Decreased oral clopidogrel absorption caused by induction of intestinal permeability glycoprotein (P‐gp) expression after aspirin administration was observed…”
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Publisher Correction: Selective enhancement of optical nonlinearity in two-dimensional organic-inorganic lead iodide perovskites by Saouma, F. O., Stoumpos, C. C., Wong, J., Kanatzidis, M. G., Jang, J. I.

“…In the PDF version of this article, Eq. 5 is missing all elements after the equals sign. The correct version of Eq. 5 is given below. The HTML version of the…”
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Pharmacokinetic and Pharmacodynamic Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 Genetic Polymorphism in Healthy Subjects by Chung, J‐Y, Cho, J‐Y, Yu, K‐S, Kim, J‐R, Lim, KS, Sohn, D‐R, Shin, S‐G, Jang, I‐J

“…Pharmacokinetic and pharmacodynamic profiles of lorazepam and valproate were analyzed according to uridine 5′‐diphosphate‐glucuronosyltransferase (UGT)2B7…”
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An Accelerator Mass Spectrometry‐Enabled Microtracer Study to Evaluate the First‐Pass Effect on the Absorption of YH4808 by Kim, A, Yu, B‐Y, Dueker, SR, Shin, K‐H, Kim, HS, Ahn, H, Cho, J‐Y, Yu, K‐S, Jang, I‐J, Lee, H

“…14C‐labeled YH4808, a novel potassium‐competitive acid blocker, was intravenously administered as a microtracer at 80 μg (11.8 kBq or 320 nCi) concomitantly…”
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Pharmacodynamic comparison of two formulations of Acarbose 100-mg tablets by Lee, S., Chung, J. Y., Hong, K. S., Yang, S.-H., Byun, S.-Y., Lim, H.-S., Shin, S.-G., Jang, I.-J., Yu, K.-S.

“…Summary What is known and Objective:  Acarbose, an α‐glycosidase inhibitor, is used to treat diabetic patients. Pharmacokinetic evaluation of acarbose is…”
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Investigation of bioequivalence of a new fixed-dose combination of acarbose and metformin with the corresponding loose combination as well as the drug-drug interaction potential between both drugs in healthy adult male subjects by Kim, S., Jang, I.-J., Shin, D., Shin, D. S., Yoon, S., Lim, K. S., Yu, K.-S., Li, J., Zhang, H., Liu, Y., Brendel, E., Blode, H., Wang, Y.

“…Summary What is known and objective Both metformin and acarbose are recommended monotherapy and add‐on therapy in type 2 diabetes mellitus (T2DM). A fixed‐dose…”
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Frequency of CYP2C9 variant alleles, including CYP2C913 in a Korean population and effect on glimepiride pharmacokinetics by Lee, H. W., Lim, M.-s., Lee, J., Jegal, M.-Y., Kim, D.-W., Lee, W.-K., Jang, I.-J., Shin, J.-G., Yoon, Y.-R.

“…Summary What is known and Objective:  Cytochrome P450 (CYP) 2C9 is a clinically important enzyme involved in the metabolism of many drugs commonly used in…”
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Response to "Induction of both P-glycoprotein and specific cytochrome P450 by Aspirin eventually does not alter the antithrombotic effect of clopidogrel" by Oh, J, Ji, SC, Lee, H, Yu, K-S, Jang, I-J

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Exploration of Biomarkers for Amoxicillin/Clavulanate‐Induced Liver Injury: Multi‐Omics Approaches by Lee, J, Ji, SC, Kim, B, Yi, S, Shin, KH, Cho, JY, Lim, KS, Lee, SH, Yoon, SH, Chung, JY, Yu, KS, Park, HS, Kim, SH, Jang, IJ

“…To explore potential biomarkers for amoxicillin/clavulanate‐induced liver injury (AC‐DILI), we conducted a clinical trial in 32 healthy subjects based on…”
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Prolonged Use of Aspirin Alters Human and Rat Intestinal Cells and Thereby Limits the Absorption of Clopidogrel by Jung, K‐H, Chu, K, Lee, S‐T, Yoon, H‐J, Chang, J‐Y, Nam, W‐S, Yoon, S‐H, Cho, J‐Y, Yu, K‐S, Jang, I‐J, Kim, M, Lee, S K, Roh, J‐K

“…Clopidogrel therapy to prevent atherothrombosis faces the challenge of reduced responsiveness. The absorption of clopidogrel is regulated by…”
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Effect of multiple doses of fimasartan, an angiotensin II receptor antagonist, on the steady-state pharmacokinetics of digoxin in healthy volunteers by Yi, S, Kim, J W, Kim, T-E, Kim, J, Jun, Y K, Choi, J, Yoon, S H, Cho, J-Y, Song, S H, Shin, S-G, Jang, I-J, Yu, K-S

“…Fimasartan (BR-A-657) is an angiotensin II receptor antagonist, recently approved as an antihypertensive agent. This study aimed to investigate whether…”
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