Search Results - "Jang, Hyunbum"

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B by Lu, Shaoyong, Jang, Hyunbum, Nussinov, Ruth, Zhang, Jian

“…Ras mediates cell proliferation, survival and differentiation. Mutations in K-Ras4B are predominant at residues G12, G13 and Q61. Even though all impair…”
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Oncogenic Ras Isoforms Signaling Specificity at the Membrane by Nussinov, Ruth, Tsai, Chung-Jung, Jang, Hyunbum

“…How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas, HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct…”
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Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view by Lu, Shaoyong, Jang, Hyunbum, Gu, Shuo, Zhang, Jian, Nussinov, Ruth

“…Ras proteins are small GTPases, cycling between inactive GDP-bound and active GTP-bound states. Through these switches they regulate signaling that controls…”
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Ras Conformational Ensembles, Allostery, and Signaling by Lu, Shaoyong, Jang, Hyunbum, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Nussinov, Ruth, Zhang, Jian

“…Ras proteins are classical members of small GTPases that function as molecular switches by alternating between inactive GDP-bound and active GTP-bound states…”
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Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains by Zhang, Mingzhen, Jang, Hyunbum, Gaponenko, Vadim, Nussinov, Ruth

“…How calmodulin (CaM) acts in KRAS-driven cancers is a vastly important question. CaM binds to and stimulates PI3Kα/Akt signaling, promoting cell growth and…”
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Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers by Nussinov, Ruth, Jang, Hyunbum, Tsai, Chung-Jung, Cheng, Feixiong

“…At the root of the so-called precision medicine or precision oncology, which is our focus here, is the hypothesis that cancer treatment would be considerably…”
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Single cell spatial biology over developmental time can decipher pediatric brain pathologies by Nussinov, Ruth, Yavuz, Bengi Ruken, Jang, Hyunbum

“…Pediatric low grade brain tumors and neurodevelopmental disorders share proteins, signaling pathways, and networks. They also share germline mutations and an…”
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Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers by Jang, Hyunbum, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Nussinov, Ruth

“…Are the dimer structures of active Ras isoforms similar? This question is significant since Ras can activate its effectors as a monomer; however, as a dimer,…”
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SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations by Liao, Tsung-Jen, Jang, Hyunbum, Fushman, David, Nussinov, Ruth

“…Grb2 is an adaptor protein connecting the epidermal growth factor receptor and the downstream Son of sevenless 1 (SOS1), a Ras-specific guanine nucleotide…”
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A New View of Ras Isoforms in Cancers by Nussinov, Ruth, Tsai, Chung-Jung, Chakrabarti, Mayukh, Jang, Hyunbum

“…Does small GTPase K-Ras4A have a single state or two states, one resembling K-Ras4B and the other N-Ras? A recent study of K-Ras4A made the remarkable…”
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Allostery in Its Many Disguises: From Theory to Applications by Wodak, Shoshana J., Paci, Emanuele, Dokholyan, Nikolay V., Berezovsky, Igor N., Horovitz, Amnon, Li, Jing, Hilser, Vincent J., Bahar, Ivet, Karanicolas, John, Stock, Gerhard, Hamm, Peter, Stote, Roland H., Eberhardt, Jerome, Chebaro, Yassmine, Dejaegere, Annick, Cecchini, Marco, Changeux, Jean-Pierre, Bolhuis, Peter G., Vreede, Jocelyne, Faccioli, Pietro, Orioli, Simone, Ravasio, Riccardo, Yan, Le, Brito, Carolina, Wyart, Matthieu, Gkeka, Paraskevi, Rivalta, Ivan, Palermo, Giulia, McCammon, J. Andrew, Panecka-Hofman, Joanna, Wade, Rebecca C., Di Pizio, Antonella, Niv, Masha Y., Nussinov, Ruth, Tsai, Chung-Jung, Jang, Hyunbum, Padhorny, Dzmitry, Kozakov, Dima, McLeish, Tom

“…Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery…”
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Ras isoform-specific expression, chromatin accessibility, and signaling by Nussinov, Ruth, Zhang, Mingzhen, Maloney, Ryan, Jang, Hyunbum

“…The anchorage of Ras isoforms in the membrane and their nanocluster formations have been studied extensively, including their detailed interactions, sizes,…”
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Inhibitors of Ras-SOS Interactions by Lu, Shaoyong, Jang, Hyunbum, Zhang, Jian, Nussinov, Ruth

“…Activating Ras mutations are found in about 30 % of human cancers. Ras activation is regulated by guanine nucleotide exchange factors, such as the son of…”
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The quaternary assembly of KRas4B with Raf-1 at the membrane by Jang, Hyunbum, Zhang, Mingzhen, Nussinov, Ruth

“…[Display omitted] Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK)…”
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Does Ras Activate Raf and PI3K Allosterically? by Nussinov, Ruth, Tsai, Chung-Jung, Jang, Hyunbum

“…The mechanism through which oncogenic Ras activates its effectors is vastly important to resolve. If allostery is at play, then targeting allosteric pathways…”
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Tumor-derived RHOA mutants interact with effectors in the GDP-bound state by Lin, Yuan, Ramelot, Theresa A., Senyuz, Simge, Gursoy, Attila, Jang, Hyunbum, Nussinov, Ruth, Keskin, Ozlem, Zheng, Yi

“…RHOA mutations are found at diverse residues in various cancer types, implying mutation- and cell-specific mechanisms of tumorigenesis. Here, we focus on the…”
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Antimicrobial Properties of Amyloid Peptides by Kagan, Bruce L, Jang, Hyunbum, Capone, Ricardo, Teran Arce, Fernando, Ramachandran, Srinivasan, Lal, Ratnesh, Nussinov, Ruth

“…More than two dozen clinical syndromes known as amyloid diseases are characterized by the buildup of extended insoluble fibrillar deposits in tissues. These…”
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Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome by Jang, Hyunbum, Arce, Fernando Teran, Ramachandran, Srinivasan, Capone, Ricardo, Azimova, Rushana, Kagan, Bruce L, Nussinov, Ruth, Lal, Ratnesh

“…Full-length amyloid beta peptides (Aβ₁₋₄₀/₄₂) form neuritic amyloid plaques in Alzheimer's disease (AD) patients and are implicated in AD pathology. However,…”
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The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas by Nussinov, Ruth, Muratcioglu, Serena, Tsai, Chung-Jung, Jang, Hyunbum, Gursoy, Attila, Keskin, Ozlem

“…KRAS4B is a highly oncogenic splice variant of the KRAS isoform. It is the only isoform associated with initiation of adenocarcinomas. Insight into why and how…”
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The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane by Jang, Hyunbum, Smith, Iris Nira, Eng, Charis, Nussinov, Ruth

“…Tumor suppressor PTEN, the second most highly mutated protein in cancer, dephosphorylates signaling lipid PIP3 produced by PI3Ks. Excess PIP3 promotes cell…”
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