Search Results - "Jang, Hagoon"

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5 by Kong, Jinuk, Ji, Yul, Jeon, Yong Geun, Han, Ji Seul, Han, Kyung Hee, Lee, Jung Hyun, Lee, Gung, Jang, Hagoon, Choe, Sung Sik, Baes, Myriam, Kim, Jae Bum

“…Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although several subcellular organelles participate in lipid metabolism,…”
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A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice by Kim, Hak Kyun, Xu, Jianpeng, Chu, Kirk, Park, Hyesuk, Jang, Hagoon, Li, Pan, Valdmanis, Paul N., Zhang, Qiangfeng Cliff, Kay, Mark A.

“…tRNA-derived small RNAs (tsRNAs) have been implicated in many cellular processes, yet the detailed mechanisms are not well defined. We previously found that…”
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Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low‐density lipoprotein receptor by Jo, Hyunsun, Choe, Sung Sik, Shin, Kyung Cheul, Jang, Hagoon, Lee, Jae Ho, Seong, Je Kyung, Back, Sung Hoon, Kim, Jae Bum

“…Recent evidence suggests that obese animals exhibit increased endoplasmic reticulum (ER) stress in the liver and adipose tissue. Although ER stress is closely…”
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SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding by Jang, Hagoon, Lee, Gha Young, Selby, Christopher P., Lee, Gung, Jeon, Yong Geun, Lee, Jae Ho, Cheng, Kenneth King Yip, Titchenell, Paul, Birnbaum, Morris J., Xu, Aimin, Sancar, Aziz, Kim, Jae Bum

“…SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of…”
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Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress by Ham, Mira, Lee, Joo-Won, Choi, A Hyun, Jang, Hagoon, Choi, Goun, Park, Jiyoung, Kozuka, Chisayo, Sears, Dorothy D., Masuzaki, Hiroaki, Kim, Jae Bum

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Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A‐dependent sterol regulatory element binding protein1c degradation by Lee, Jae Ho, Lee, Gha Young, Jang, Hagoon, Choe, Sung Sik, Koo, Seung‐Hoi, Kim, Jae Bum

“…Sterol regulatory element binding protein1c (SREBP1c) is a key transcription factor for de novo lipogenesis during the postprandial state. During nutritional…”
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PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling by Lee, Gha Young, Jang, Hagoon, Lee, Jae Ho, Huh, Jin Young, Choi, Sekyu, Chung, Jongkyeong, Kim, Jae Bum

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AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity by Lee, Joo-Won, Choe, Sung Sik, Jang, Hagoon, Kim, Jiyeong, Jeong, Hyun Woo, Jo, Hyunsun, Jeong, Kyeong-Hoon, Tadi, Surendar, Park, Myoung Gyu, Kwak, Tae Hwan, Man Kim, Jin, Hyun, Dong-Hoon, Kim, Jae Bum

“…In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. In…”
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Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice by Jang, Hagoon, Lee, Gung, Kong, Jinuk, Choi, Goun, Park, Yoon Jeong, Kim, Jae Bum

“…Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a…”
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SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity by Lee, Gung, Kim, Ye Young, Jang, Hagoon, Han, Ji Seul, Nahmgoong, Hahn, Park, Yoon Jeong, Han, Sang Mun, Cho, Changyun, Lim, Sangsoo, Noh, Jung-Ran, Oh, Won Keun, Lee, Chul-Ho, Kim, Sun, Kim, Jae Bum

“…Emerging evidence indicates that the accretion of senescent cells is linked to metabolic disorders. However, the underlying mechanisms and metabolic…”
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Dysregulation of CRY1 Promotes Hyperglycemia in Diabetic Mice by Kim, Ye Young, Jang, Hagoon, Lee, Geung, Jeon, Yong Geun, Kim, Jae Bum

“…Abnormally activated hepatic glucose production (HGP) is one of major factors contributing to hyperglycemia in diabetes. Recently, we have reported that…”
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SREBP1c-CRY1 axis suppresses hepatic gluconeogenesis upon insulin by Jang, Hagoon, Lee, Gung, Kim, Jae Bum

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Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice by Tsuji, Shinnosuke, Stephens, Calvin J., Bortolussi, Giulia, Zhang, Feijie, Baj, Gabriele, Jang, Hagoon, de Alencastro, Gustavo, Muro, Andrés F., Pekrun, Katja, Kay, Mark A.

“…Homologous recombination (HR)-based gene therapy using adeno-associated viruses (AAV-HR) without nucleases has several advantages over classic gene therapy,…”
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RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer by Lee, Jae Ho, Jeon, Yong Geun, Lee, Kyoung-Hwa, Lee, Hye Won, Park, Jeu, Jang, Hagoon, Kang, Minyong, Lee, Hye Sun, Cho, Hee Jin, Nam, Do-Hyun, Kwak, Cheol, Kim, Jae Bum

“…Elevated lipid metabolism promotes cancer cell proliferation. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers,…”
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Abstract LB-343: A Leu(CAG)-tRNA derived small RNA regulates ribosomal protein S28 after translation initiation in both human and mouse liver cancers by Kim, Hak Kyun, Xu, Jianpeng, Chu, Kirk, Park, Hyesuk, jang, Hagoon, Li, Pan, Valdmanis, Paul, Zhang, Qiangpeng, Kay, Mark

“…Abstract Transfer-RNA-derived small RNA (tsRNA) is implicated in regulating many cellular processes and is dysregulated in various diseases. We recently…”
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SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress by Lee, Gung, Jang, Hagoon, Kim, Ye Young, Choe, Sung Sik, Kong, Jinuk, Hwang, Injae, Park, Jeu, Im, Seung-Soon, Kim, Jae Bum

“…SREBP1c is a key transcription factor for de novo lipogenesis. Although SREBP1c is expressed in pancreatic islets, its physiological roles in pancreatic…”
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Hepatic GSK3β-dependent CRY1 Degradation Contributes to Diabetic Hyperglycemia by Kim, Ye Young, Jang, Hagoon, Lee, Gung, Jeon, Yong Geun, Sohn, Jee Hyung, Han, Ji Seul, Lee, Won Taek, Park, Jeu, Huh, Jin Young, Nahmgoong, Hahn, Han, Sang Mun, Kim, Jeesoo, Pak, Minwoo, Kim, Sun, Kim, Jong-Seo, Kim, Jae Bum

“…Excessive hepatic glucose production (HGP) is a key factor promoting hyperglycemia in diabetes. Hepatic cryptochrome 1 (CRY1) plays an important role in…”
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Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex by de Alencastro, Gustavo, Puzzo, Francesco, Pavel-Dinu, Mara, Zhang, Feijie, Pillay, Sirika, Majzoub, Karim, Tiffany, Matthew, Jang, Hagoon, Sheikali, Adam, Cromer, M. Kyle, Meetei, Ruhikanta, Carette, Jan E., Porteus, Matthew H., Pekrun, Katja, Kay, Mark A.

“…Recombinant adeno-associated virus (rAAV) vectors have the unique property of being able to perform genomic targeted integration (TI) without inducing a…”
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SREBP1c-PAX4 Axis Mediates Pancreatic ß-Cell Compensatory Responses Upon Metabolic Stress by Lee, Gung, Jang, Hagoon, Kim, Ye Young, Choe, Sung Sik, Kong, Jinuk, Kim, Jae Bum, Im, Seung-Soon, Hwang, Injae, Park, Jeu

“…SREBP1c is a key transcription factor for de novo lipogenesis. Although SREBP1c is expressed in pancreatic islets, its physiological roles in pancreatic…”
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Hyperglycemia is exacerbated by dysregulation of hepatic SREBP1c‐CRY1 signaling pathway by KIM, JAE BUM, CHOI, WON GUN, JANG, HAGOON, LEE, GHA YOUNG, LEE, GUNG, JEON, YONG GEUN

“…Abstract only SREBP1c is a key transcription factor of lipogenesis to store excess energy in postprandial state. Although SREBP1c appears to be involved in…”
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