Search Results - "Janey, Jacob"

Bayesian reaction optimization as a tool for chemical synthesis by Shields, Benjamin J., Stevens, Jason, Li, Jun, Parasram, Marvin, Damani, Farhan, Alvarado, Jesus I. Martinez, Janey, Jacob M., Adams, Ryan P., Doyle, Abigail G.

“…Reaction optimization is fundamental to synthetic chemistry, from optimizing the yield of industrial processes to selecting conditions for the preparation of…”
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Recent Advances in Catalytic, Enantioselective α Aminations and α Oxygenations of Carbonyl Compounds by Janey, Jacob M.

“…The direct introduction of either a nitrogen or oxygen atom adjacent to a carbonyl group in a catalytic, enantioselective manner using both chiral Lewis acid…”
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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture by Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.

“…Pharmaceutical synthesis can benefit greatly from the selectivity gains associated with enzymatic catalysis. Here, we report an efficient biocatalytic process…”
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Development of a Platform for Near-Infrared Photoredox Catalysis by Ravetz, Benjamin D, Tay, Nicholas E. S, Joe, Candice L, Sezen-Edmonds, Melda, Schmidt, Michael A, Tan, Yichen, Janey, Jacob M, Eastgate, Martin D, Rovis, Tomislav

“…Over the past decade, chemists have embraced visible-light photoredox catalysis due to its remarkable ability to activate small molecules. Broadly, these…”
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Scalable Asymmetric Synthesis of MK-8998, a T‑Type Calcium Channel Antagonist by Zhong, Yong-Li, Moore, Jeffrey C, Shevlin, Michael, Shultz, C. Scott, Kosjek, Birgit, Chen, Yonggang, Janey, Jacob M, Tan, Lushi

“…Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building…”
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Direct Lewis Acid Catalyzed Conversion of Enantioenriched N‑Acyloxazolidinones to Chiral Esters, Amides, and Acids by Stevens, Jason M, Parra-Rivera, Ana Cristina, Dixon, Darryl D, Beutner, Gregory L, DelMonte, Albert J, Frantz, Doug E, Janey, Jacob M, Paulson, James, Talley, Michael R

“…The identification of Yb­(OTf)3 through a multivariable high-throughput experimentation strategy has enabled a unified protocol for the direct conversion of…”
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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction by Xu, Feng, Kosjek, Birgit, Cabirol, Fabien L., Chen, Haibin, Desmond, Richard, Park, Jeonghan, Gohel, Anupam P., Collier, Steven J., Smith, Derek J., Liu, Zhuqing, Janey, Jacob M., Chung, John Y. L., Alvizo, Oscar

“…Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment…”
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Enantioselective Synthesis of a γ‑Secretase Modulator via Vinylogous Dynamic Kinetic Resolution by Strotman, Neil A, Ramirez, Antonio, Simmons, Eric M, Soltani, Omid, Parsons, Andrew T, Fan, Yu, Sawyer, James R, Rosner, Thorsten, Janey, Jacob M, Tran, Kristy, Li, Jun, La Cruz, Thomas E, Pathirana, Charles, Ng, Alicia T, Deerberg, Joerg

“…Two efficient asymmetric routes to γ-secretase modulator BMS-932481, under investigation for Alzheimer’s disease, have been developed. The key step for the…”
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Proline-Catalyzed, Asymmetric Mannich Reactions in the Synthesis of a DPP-IV Inhibitor by Janey, Jacob M, Hsiao, Yi, Armstrong, Joseph D

“…A highly stereoselective l-proline-catalyzed, asymmetric direct Mannich reaction between a glyoxalate-derived imine and phenyl acetaldehyde was employed for…”
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A biocatalytic/reductive etherification approach to substituted piperidinyl ethers by Kuethe, Jeffrey T., Janey, Jacob M., Truppo, Matthew, Arredondo, Juan, Li, Tao, Yong, Kelvin, He, Shuwen

“…A synthetically useful protocol has been developed for the preparation of highly functionalized piperidinyl ethers. Biocatalytic reduction of cyclhexanones 7,…”
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Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation by Song, Zhiguo J, Tellers, David M, Dormer, Peter G, Zewge, Daniel, Janey, Jacob M, Nolting, Andrew, Steinhuebel, Dietrich, Oliver, Steven, Devine, Paul N, Tschaen, David M

“…A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline,…”
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A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633 by Gosselin, Francis, Britton, Robert A, Davies, Ian W, Dolman, Sarah J, Gauvreau, Danny, Hoerrner, R. Scott, Hughes, Gregory, Janey, Jacob, Lau, Stephen, Molinaro, Carmela, Nadeau, Christian, O’Shea, Paul D, Palucki, Michael, Sidler, Rick

“…Practical, chromatography-free syntheses of 5-lipoxygenase inhibitor MK-0633 p-toluenesulfonate (1) are described. The first route used an asymmetric zincate…”
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C 2-Symmetric Cu(II) Complexes as Chiral Lewis Acids. Catalytic, Enantioselective Cycloadditions of Silyl Ketenes by Evans, David A, Janey, Jacob M

“…C 2-Symmetric bis(oxazoline)−Cu(II) complexes (4a−g) catalyze the enantioselective [2 + 2] cycloaddition between (silyl)ketenes and chelating carbonyl…”
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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction by Xu, Feng, Kosjek, Birgit, Cabirol, Fabien L., Chen, Haibin, Desmond, Richard, Park, Jeonghan, Gohel, Anupam P., Collier, Steven J., Smith, Derek J., Liu, Zhuqing, Janey, Jacob M., Chung, John Y. L., Alvizo, Oscar

“…Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment…”
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Raney-Co Mediated Reductive Cyclization of an α,β-Unsaturated Nitrile by Janey, Jacob M., Orella, Charles J., Njolito, Eugenia, Baxter, Jenny M., Rosen, Jonathan D., Palucki, Michael, Sidler, Rick R., Li, Wenjie, Kowal, Jason J., Davies, Ian W.

“…An expedient, five step synthesis of caprolactam 1 is reported starting from natural L-homoserine. The key step is a chemoselective reductive cyclization of…”
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Racemic and Asymmetric Diels−Alder Reactions of 1-(2-Oxazolidinon-3-yl)-3-siloxy-1,3-butadienes by Janey, Jacob M, Iwama, Tetsuo, Kozmin, Sergey A, Rawal, Viresh H

“…Achiral and chiral 1-(2-oxazolidinon-3-yl)-3-siloxy-1,3-butadienes were prepared from readily available starting materials. Although more stable than the…”
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1-Amino-3-siloxy-1,3-butadienes:  Highly Reactive Dienes for the Diels−Alder Reaction by Kozmin, Sergey A, Janey, Jacob M, Rawal, Viresh H

“…1-Amino-3-siloxy-1,3-butadienes represent a novel class of heteroatom-containing dienes with several useful properties. These dienes can be prepared…”
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Solubility Behaviors and Correlations of Common Organic Solvents by Qiu, Jun, Albrecht, Jacob, Janey, Jacob

“…Through a statistical analysis of empirical solubility data collected from over 1000 solutes, the solubility behaviors of 53 common solvents are characterized…”
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Solubility Behaviors and Correlations of Common Solvent–Antisolvent Systems by Qiu, Jun, Albrecht, Jacob, Janey, Jacob

“…This report is a follow-up to our two prior publications that analyzed solubility behaviors and correlations of common solvents. The statistical results…”
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Synergistic Solvation Effects: Enhanced Compound Solubility Using Binary Solvent Mixtures by Qiu, Jun, Albrecht, Jacob, Janey, Jacob

“…We explain the concept of solubility synergistic solvation (also known as parabolic solubility), wherein a binary solvent mixture exhibits a higher solubility…”
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