Search Results - "Janet Kelsall"

Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity by Wright, Phillip, Kelsall, Janet, Healing, Guy, Sanderson, Julie

“…Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for…”
Get full text

Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women by Njoku, Kelechi, Pierce, Andrew, Geary, Bethany, Campbell, Amy E., Kelsall, Janet, Reed, Rachel, Armit, Alexander, Da Sylva, Rachel, Zhang, Liqun, Agnew, Heather, Baricevic-Jones, Ivona, Chiasserini, Davide, Whetton, Anthony D., Crosbie, Emma J.

“…Background A non-invasive endometrial cancer detection tool that can accurately triage symptomatic women for definitive testing would improve patient care…”
Get full text

The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination by McGurk, Kathryn A, Dagliati, Arianna, Chiasserini, Davide, Lee, Dave, Plant, Darren, Baricevic-Jones, Ivona, Kelsall, Janet, Eineman, Rachael, Reed, Rachel, Geary, Bethany, Unwin, Richard D, Nicolaou, Anna, Keavney, Bernard D, Barton, Anne, Whetton, Anthony D, Geifman, Nophar

“…Abstract Motivation Data-independent acquisition mass spectrometry allows for comprehensive peptide detection and relative quantification than standard…”
Get full text

A Prostate Cancer Proteomics Database for SWATH-MS Based Protein Quantification by Muazzam, Ammara, Chiasserini, Davide, Kelsall, Janet, Geifman, Nophar, Whetton, Anthony D., Townsend, Paul A.

“…Prostate cancer is the most frequent form of cancer in men, accounting for more than one-third of all cases. Current screening techniques, such as PSA testing…”
Get full text

Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: leveraging proteomics and machine learning for biomarker discoveryResearch in context by Kelechi Njoku, Andrew Pierce, Davide Chiasserini, Bethany Geary, Amy E. Campbell, Janet Kelsall, Rachel Reed, Nophar Geifman, Anthony D. Whetton, Emma J. Crosbie

“…Background: The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in…”
Get full text

Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: leveraging proteomics and machine learning for biomarker discovery by Njoku, Kelechi, Pierce, Andrew, Chiasserini, Davide, Geary, Bethany, Campbell, Amy E., Kelsall, Janet, Reed, Rachel, Geifman, Nophar, Whetton, Anthony D., Crosbie, Emma J.

“…The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in cervico-vaginal…”
Get full text

Proteomic analysis identifies subgroups of patients with active systemic lupus erythematosus by Su, Kevin Y C, Reynolds, John A, Reed, Rachel, Da Silva, Rachael, Kelsall, Janet, Baricevic-Jones, Ivona, Lee, David, Whetton, Anthony D, Geifman, Nophar, McHugh, Neil, Bruce, Ian N

“…Systemic lupus erythematosus (SLE) is a clinically and biologically heterogenous autoimmune disease. We aimed to investigate the plasma proteome of patients…”
Get full text

Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemiaResearch in context by Weronika E. Borek, Luis Nobre, S. Federico Pedicona, Amy E. Campbell, Josie A. Christopher, Nazrath Nawaz, David N. Perkins, Pedro Moreno-Cardoso, Janet Kelsall, Harriet R. Ferguson, Bela Patel, Paolo Gallipoli, Andrea Arruda, Alex J. Ambinder, Andrew Thompson, Andrew Williamson, Gabriel Ghiaur, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas, Arran D. Dokal

“…Background: Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with…”
Get full text

Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia by Borek, Weronika E., Nobre, Luis, Pedicona, S. Federico, Campbell, Amy E., Christopher, Josie A., Nawaz, Nazrath, Perkins, David N., Moreno-Cardoso, Pedro, Kelsall, Janet, Ferguson, Harriet R., Patel, Bela, Gallipoli, Paolo, Arruda, Andrea, Ambinder, Alex J., Thompson, Andrew, Williamson, Andrew, Ghiaur, Gabriel, Minden, Mark D., Gribben, John G., Britton, David J., Cutillas, Pedro R., Dokal, Arran D.

“…Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with intensive…”
Get full text

Understanding the preclinical toxicity profile of standard of care oncology agent carboplatin: Effect of a 7-cycle treatment on bone marrow and peripheral cell depletion and recovery in the Han Wistar rat by Kelsall, Janet, Walker, Clare, Sadler, Claire, Cotton, Peter, Moore, Nick, Slater, Ian, Barnes, Jen, Oplustilova, Lenka

Get full text

Understanding the preclinical toxicity profile of standard of care oncology agent carboplatin: Dose response on haematological and bone marrow markers in the Hans Wistar rat by Sadler, Claire, Kelsall, Janet, Wilkinson, Catherine, Derbyshire, Nicola, Grant, Claire, Oplustilova, Lenka

Get full text

Localisation of novel miRNA biomarkers of doxorubicin-induced cardiotoxicity in rats by Barnes, Claire, Kelsall, Janet, Smith, Susan, Cove-Smith, Laura, Mellor, Howard, Hargreaves, Adam, Price, Sally

Get full text

Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites by Thompson, Karol L, Boitier, Eric, Chen, Tao, Couttet, Philippe, Ellinger-Ziegelbauer, Heidrun, Goetschy, Manuela, Guillemain, Gregory, Kanki, Masayuki, Kelsall, Janet, Mariet, Claire, de La Moureyre-Spire, Catherine, Mouritzen, Peter, Nassirpour, Rounak, O'Lone, Raegan, Pine, P Scott, Rosenzweig, Barry A, Sharapova, Tatiana, Smith, Aaron, Uchiyama, Hidefumi, Yan, Jian, Yuen, Peter S, Wolfinger, Russ

“…Extracellular microRNAs (miRNAs) represent a promising new source of toxicity biomarkers that are sensitive indicators of site of tissue injury. In order to…”
Get full text

The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia by Tonge, Daniel P, Tugwood, Jonathan D, Kelsall, Janet, Gant, Timothy W

“…Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in extracellular matrix (ECM) homeostasis. MMPs have been an attractive…”
Get full text

Fibrodysplasia induced in dog skin by a matrix metalloproteinase (MMP) inhibitor--a mechanistic analysis by Tugwood, Jonathan D, Kelsall, Janet, Coverley, Lucy C, Westwood, F Russell, Haque, Kemal, Huby, Russell D J

“…Matrix metalloproteinase (MMP) inhibitors, candidate therapeutic agents for a number of diseases, are known to be associated with acute fibrosis-type adverse…”
Get full text

A. R. Kelsall TD, MD, FRCP by Kelsall, Janet

Get full text

Fatty acids, peroxisome proliferator-activated receptors and pancreatic gene expression by Kelsall, Janet

“…NIDDM is a chronic and progressive disorder resulting from abnormal glucose and lipid metabolism. Two central interrelated defects in the pathogenesis of the…”
Get full text