Search Results - "Jane Rylett, R."

Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues by Skirzewski, Miguel, Princz-Lebel, Oren, German-Castelan, Liliana, Crooks, Alycia M., Kim, Gerard Kyungwook, Tarnow, Sophie Henke, Reichelt, Amy, Memar, Sara, Palmer, Daniel, Li, Yulong, Jane Rylett, R., Saksida, Lisa M., Prado, Vania F., Prado, Marco A. M., Bussey, Timothy J.

“…The ability to learn Pavlovian associations from environmental cues predicting positive outcomes is critical for survival, motivating adaptive behaviours. This…”
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Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer's Disease by Winick-Ng, Warren, Rylett, R Jane

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synapse dysfunction and cognitive impairment. Understanding the…”
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Infiltrating Hematogenous Macrophages Aggregate Around β-Amyloid Plaques in an Age- and Sex-Dependent Manner in a Mouse Model of Alzheimer Disease by Kozyrev, Natalie, Albers, Shawn, Yang, Jennifer, Prado, Vania F, Prado, Marco A M, Fonseca, Gregory J, Rylett, R Jane, Dekaban, Gregory A

“…Abstract β-Amyloid (Aβ) plaques can trigger chronic inflammation in the cellular environment that recruits infiltrating macrophages during the course of…”
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Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT by Fishwick, Katherine J, Rylett, R Jane

“…Studies in humans and animal models show that neuronal insulin resistance increases the risk of developing Alzheimer's Disease (AD), and that insulin treatment…”
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Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin by Hristova, Ventzislava A., Beasley, Steven A., Rylett, R. Jane, Shaw, Gary S.

“…Missense mutations in park2, encoding the parkin protein, account for ∼50% of autosomal recessive juvenile Parkinson disease (ARJP) cases. Parkin belongs to…”
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Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP by Morey, Trevor M, Winick-Ng, Warren, Seah, Claudia, Rylett, R Jane

“…Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the…”
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Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking by Cuddy, Leah K, Gordon, Alexis C, Black, Stefanie A G, Jaworski, Ewa, Ferguson, Stephen S G, Rylett, R Jane

“…Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO⁻) donor]; ONOO⁻ can be produced…”
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SPAAC Pulse-Chase: A Novel Click Chemistry-Based Method to Determine the Half-Life of Cellular Proteins by Morey, Trevor M., Esmaeili, Mohammad Ali, Duennwald, Martin L., Rylett, R. Jane

“…Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to…”
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The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function by de Castro, Braulio M., De Jaeger, Xavier, Martins-Silva, Cristina, Lima, Ricardo D. F., Amaral, Ernani, Menezes, Cristiane, Lima, Patricia, Neves, Cintia M. L., Pires, Rita G., Gould, Thomas W., Welch, Ian, Kushmerick, Christopher, Guatimosim, Cristina, Izquierdo, Ivan, Cammarota, Martin, Rylett, R. Jane, Gomez, Marcus V., Caron, Marc G., Oppenheim, Ronald W., Prado, Marco A. M., Prado, Vania F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT by Cuddy, Leah K, Seah, Claudia, Pasternak, Stephen H, Rylett, R Jane

“…Alzheimer's disease (AD) is a common age-related neurodegenerative disorder that is characterized by progressive cognitive decline. The deficits in cognition…”
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Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice by Albers, Shawn, Inthathirath, Fatima, Gill, Sandeep K, Winick-Ng, Warren, Jaworski, Ewa, Wong, Daisy Y.L, Gros, Robert, Rylett, R. Jane

“…Abstract Alzheimer disease (AD) is associated with increased amyloidogenic processing of amyloid precursor protein (APP) to β-amyloid peptides (Aβ),…”
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Amyloid‐beta oligomers increase the localization of prion protein at the cell surface by Caetano, Fabiana A., Beraldo, Flavio H., Hajj, Glaucia N. M., Guimaraes, Andre L., Jürgensen, Sofia, Wasilewska‐Sampaio, Ana Paula, Hirata, Pedro H. F., Souza, Ivana, Machado, Cleiton F., Wong, Daisy Y.‐L., De Felice, Fernanda G., Ferreira, Sergio T., Prado, Vania F., Rylett, R. Jane, Martins, Vilma R., Prado, Marco A. M.

“…J. Neurochem. (2011) 117, 538–553. In Alzheimer’s disease, the amyloid‐β peptide (Aβ) interacts with distinct proteins at the cell surface to interfere with…”
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The “ins” and “outs” of the high‐affinity choline transporter CHT1 by Ribeiro, Fabiola M., Black, Stefanie A. G., Prado, Vania F., Rylett, R. Jane, Ferguson, Stephen S. G., Prado, Marco A. M.

“…Maintenance of acetylcholine (ACh) synthesis depends on the activity of the high‐affinity choline transporter (CHT1), which is responsible for the reuptake of…”
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Mobility and Cognition in Seniors. Report from the 2008 Institute of Aging (CIHR) Mobility and Cognition Workshop by Montero-Odasso, Manuel, Bherer, Louis, Studenski, Stephanie, Gopaul, Karen, Oteng-Amoako, Afua, Woolmore-Goodwin, Sarah, Stoole, Paul, Wells, Jennie, Doherty, Timothy, Zecevic, Aleksandra A, Galinsky, David, Rylett, R Jane, Jutai, Jeffrey, Muir-Hunter, Susan, Speechley, Mark, Camicioli, Richard

“…The annual Scientific Meeting of the Canadian Association on Gerontology was held on October 24 and 25, 2008 in London, Ontario. Prior to the annual meeting,…”
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82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease by Gill, Sandeep K, Ishak, Margaret, Dobransky, Tomas, Haroutunian, Vahram, Davis, Kenneth L, Rylett, R. Jane

“…Abstract Cholinergic neurons express choline acetyltransferase (ChAT) which synthesizes acetylcholine. We show here for the first time that primate-specific…”
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Constitutive high‐affinity choline transporter endocytosis is determined by a carboxyl‐terminal tail dileucine motif by Ribeiro, Fabiola M., Black, Stefanie A. G., Cregan, Sean P., Prado, Vania F., Prado, Marco A. M., Rylett, R. Jane, Ferguson, Stephen S. G.

“…Maintenance of acetylcholine synthesis depends on the effective functioning of a high‐affinity sodium‐dependent choline transporter (CHT1). Recent studies have…”
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Assessing the Severity of Perinatal Hypoxia-Ischemia in Piglets Using Near-Infrared Spectroscopy to Measure the Cerebral Metabolic Rate of Oxygen by Tichauer, Kenneth M, Wong, Daisy Y L, Hadway, Jennifer A, Rylett, R Jane, Lee, Ting-Yim, St. Lawrence, Keith

“…Reduced cerebral function after neonatal hypoxia-ischemia is an early indicator of hypoxic-ischemic encephalopathy. Near-infrared spectroscopy offers a…”
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Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter by Ribeiro, Fabiola M., Pinthong, Metta, Black, Stefanie A. G., Gordon, Alexis C., Prado, Vania F., Prado, Marco A. M., Rylett, R. Jane, Ferguson, Stephen S. G.

“…The high‐affinity choline transporter (CHT1) is responsible for uptake of choline from the synaptic cleft and supplying choline for acetylcholine synthesis…”
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Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production by Newington, Jordan T., Rappon, Tim, Albers, Shawn, Wong, Daisy Y., Rylett, R.Jane, Cumming, Robert C.

“…We previously demonstrated that nerve cell lines selected for resistance to amyloid β (Aβ) peptide exhibit elevated aerobic glycolysis in part due to increased…”
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Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite by Pinthong, Metta, Black, Stefanie A G, Ribeiro, Fabiola M, Pholpramool, Chumpol, Ferguson, Stephen S G, Rylett, R Jane

“…Excess formation of nitric oxide and superoxide by-products (peroxynitrite, reactive oxygen, and reactive nitrogen species) attenuates cholinergic transmission…”
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