Search Results - "Jane Chisholm"

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy by Mastorakos, Panagiotis, Adriana L. da Silva, Jane Chisholm, Eric Song, Won Kyu Choi, Michael P. Boyle, Marcelo M. Morales, Justin Hanes, Jung Soo Suk

“…Gene therapy has emerged as an alternative for the treatment of diseases refractory to conventional therapeutics. Synthetic nanoparticle-based gene delivery…”
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Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats by Zhang, Clark, Nance, Elizabeth A., Mastorakos, Panagiotis, Chisholm, Jane, Berry, Sneha, Eberhart, Charles, Tyler, Betty, Brem, Henry, Suk, Jung Soo, Hanes, Justin

“…Glioblastoma multiforme (GBM) is highly invasive and uniformly fatal, with median survival<20months after diagnosis even with the most aggressive treatment…”
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Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD by Chisholm, Jane F, Shenoy, Siddharth K, Shade, Julie K, Kim, Victor, Putcha, Nirupama, Carson, Kathryn A, Wise, Robert, Hansel, Nadia N, Hanes, Justin S, Suk, Jung Soo, Neptune, Enid

“…Perturbations in airway mucus properties contribute to lung function decline in patients with chronic obstructive pulmonary disease (COPD). While alterations…”
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Protein nanocages that penetrate airway mucus and tumor tissue by Huang, Xinglu, Chisholm, Jane, Zhuang, Jie, Xiao, Yanyu, Duncan, Gregg, Chen, Xiaoyuan, Suk, Jung Soo, Hanes, Justin

“…Reports on drug delivery systems capable of overcoming multiple biological barriers are rare. We introduce a nanoparticle-based drug delivery technology…”
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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy by Osman, Gizem, Rodriguez, Jason, Chan, Sze Yan, Chisholm, Jane, Duncan, Gregg, Kim, Namho, Tatler, Amanda L., Shakesheff, Kevin M., Hanes, Justin, Suk, Jung Soo, Dixon, James E.

“…The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are…”
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Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation by Schneider, Craig S, Xu, Qingguo, Boylan, Nicholas J, Chisholm, Jane, Tang, Benjamin C, Schuster, Benjamin S, Henning, Andreas, Ensign, Laura M, Lee, Ethan, Adstamongkonkul, Pichet, Simons, Brian W, Wang, Sho-Yu S, Gong, Xiaoqun, Yu, Tao, Boyle, Michael P, Suk, Jung Soo, Hanes, Justin

“…Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the…”
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Direct methanol fuel cell membranes from Nafion–polybenzimidazole blends by Wycisk, Ryszard, Chisholm, Jane, Lee, Jeong, Lin, Jun, Pintauro, Peter N.

“…Proton conducting membranes for a direct methanol fuel cell (DMFC) were fabricated from blends of Nafion ® and polybenzimidazole (PBI) by solution casting…”
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Signaling by N- and C-Terminal Sequences of Parathyroid Hormone-Related Protein in Hippocampal Neurons by Fukayama, Shoichi, Tashjian, Armen H., Davis, John N., Chisholm, Jane C.

“…Parathyroid hormone-related protein (PTHrP) is synthesized in the brain, and a single type of cloned receptor for the N-terminal portion of PTHrP and PTH is…”
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Alois Alzheimer and the amyloid debate by Davis, John N, Chisholm, Jane C

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Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces by Yu, Tao, Chisholm, Jane, Choi, Woo Jin, Anonuevo, Abraham, Pulicare, Sarah, Zhong, Weixi, Chen, Minmin, Fridley, Colleen, Lai, Samuel K., Ensign, Laura M., Suk, Jung Soo, Hanes, Justin

“…Mucus‐penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco‐inert coatings that enable particles to effectively bypass the…”
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Utilization of sudan black B in conjunction with Alexa dyes to diminish lipofuscin autofluorescence in human neuronal tissue and controlled mouse tissue by O'Herron, Timothy M., Callahan, Linda M., Chisholm, Jane C., Coleman, Paul D.

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Neuropharmacology of nimodipine: from single channels to behavior by Fanelli, R J, McCarthy, R T, Chisholm, J

“…To supplement the existing pharmacological evidence describing the effects of nimodipine, a 1,4-dihydropyridine with calcium channel blocking properties, our…”
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Factors contributing to criminal justice system involvement among individuals with developmental disabilities by Chisholm, Sarah Jane

“…This study examined the factors that may contribute to a person's with a developmental disability becoming involved in the criminal justice system by examining…”
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cis-Acting negative regulatory element of prolactin gene by Zhang, Z.X. (Harvard School of Dental Medicine, Boston, MA), Kumar, V, Rivera, R.T, Chisholm, J, Biswas, D.K

“…The prolactin (PRL) gene in clonal strains of rat pituitary tumor cells in culture (GH cells) exhibit several regulatory responses, similar to the ones…”
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Developmental hyperthermic seizures alter adult hippocampal benzodiazepine binding and morphology by Chisholm, J, Kellogg, C, Franck, J E

“…Experimental hyperthermic seizures in 15-day-old rats resulted in both an alteration in the benzodiazepine (BDZ) binding site in the hippocampal region and…”
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The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation by Brorson, J R, Bindokas, V P, Iwama, T, Marcuccilli, C J, Chisholm, J C, Miller, R J

“…Although a neurotoxic role has been postulated for the beta-amyloid protein (beta AP), which accumulates in brain tissues in Alzheimer's disease, a precise…”
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Suppression of prolactin gene expression in GH cells correlates with site-specific DNA methylation by Zhang, Z X, Kumar, V, Rivera, R T, Pasion, S G, Chisholm, J, Biswas, D K

“…Prolactin- (PRL) producing and nonproducing subclones of the GH line of (rat) pituitary tumor cells have been compared to elucidate the regulatory mechanisms…”
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A mitochondrial bottleneck hypothesis of Alzheimer's disease by Davis, John N., Hunnicutt, Edward J., Chisholm, Jane C.

“…Alzheimer's disease, in its early onset familial form, is known to be a heterogeneous disorder. This suggests that the different degenerative mechanisms,…”
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Feeding and drinking in rats maintained on a low protein diet by Jalowice, J E, Chisholm, J A, Forbes, W B, Morgane, P J, Resnick, O

“…Male and female rats born of protein malnourished mothers were fed a low-protein diet (8% casein) for 150 days after weaning and daily food and water intakes…”
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