Search Results - "Jane, Stephen M."

Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis by Darido, Charbel, Georgy, Smitha R., Wilanowski, Tomasz, Dworkin, Sebastian, Auden, Alana, Zhao, Quan, Rank, Gerhard, Srivastava, Seema, Finlay, Moira J., Papenfuss, Anthony T., Pandolfi, Pier Paolo, Pearson, Richard B., Jane, Stephen M.

“…Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription…”
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The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance by Mathangasinghe, Yasith, Fauvet, Bruno, Jane, Stephen M, Goloubinoff, Pierre, Nillegoda, Nadinath B

“…Erythropoiesis is a tightly regulated cell differentiation process in which specialized oxygen- and carbon dioxide-carrying red blood cells are generated in…”
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Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin by Mlacki, Michal, Darido, Charbel, Jane, Stephen M, Wilanowski, Tomasz

“…The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis…”
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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing by Tan, Yuen T, Moritz, Robert L, Simpson, Richard J, Allis, C David, Jane, Stephen M, Zhao, Quan, Li, Haitao, Patel, Dinshaw J, Curtis, David J, Rank, Gerhard, Cerruti, Loretta, Cunningham, John M

“…Mammalian gene silencing is associated with both histone and DNA methylation. The PRMT5 arginine histone methyltransferase is now found to affect DNA…”
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YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells by Bai, Yuchen, Gotz, Carolin, Chincarini, Ginevra, Zhao, Zixuan, Slaney, Clare, Boath, Jarryd, Furic, Luc, Angel, Christopher, Jane, Stephen M., Phillips, Wayne A., Stacker, Steven A., Farah, Camile S., Darido, Charbel

“…In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are currently missing. An integrated analysis of patient HNC subtypes using…”
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Inhibition of retinoic acid signaling impairs cranial and spinal neural tube closure in mice lacking the Grainyhead-like 3 transcription factor by Deng, Zihao, Carpinelli, Marina R., Butt, Tariq, Magor, Graham W., Perkins, Andrew C., Jane, Stephen M.

“…Neural tube closure is a dynamic morphogenic event in early embryonic development. Perturbations of this process through either environmental or genetic…”
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Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells by Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M., Curtis, David J.

“…Intensive chemotherapy for acute leukemia can usually induce complete remission, but fails in many patients to eradicate the leukemia stem cells responsible…”
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Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse by de Vries, Michael, Carpinelli, Marina, Rutland, Emilie, Hatzipantelis, Aaron, Partridge, Darren, Auden, Alana, Anderson, Peter J., De Groef, Bert, Wu, Han, Osterwalder, Marco, Visel, Axel, Jane, Stephen M., Dworkin, Sebastian

“…The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of embryogenesis that regulate cellular survival, proliferation,…”
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Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway by Caddy, Jacinta, Wilanowski, Tomasz, Darido, Charbel, Dworkin, Sebastian, Ting, Stephen B., Zhao, Quan, Rank, Gerhard, Auden, Alana, Srivastava, Seema, Papenfuss, Tony A., Murdoch, Jennifer N., Humbert, Patrick O., Boulos, Nidal, Weber, Thomas, Zuo, Jian, Cunningham, John M., Jane, Stephen M.

“…The mammalian PCP pathway regulates diverse developmental processes requiring coordinated cellular movement, including neural tube closure and cochlear…”
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Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs by Kersbergen, Ariena, Best, Sarah A., Dworkin, Sebastian, Ah-Cann, Casey, de Vries, Michael E., Asselin-Labat, Marie-Liesse, Ritchie, Matthew E., Jane, Stephen M., Sutherland, Kate D.

“…The highly conserved transcription factor Grainyhead-like 2 (Grhl2) exhibits a dynamic expression pattern in lung epithelium throughout embryonic development…”
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Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression by Rank, Gerhard, Cerruti, Loretta, Simpson, Richard J., Moritz, Robert L., Jane, Stephen M., Zhao, Quan

“…Defining the molecular mechanisms underpinning fetal (γ) globin gene silencing may provide strategies for reactivation of γ-gene expression, a major…”
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Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life by Cangkrama, Michael, Darido, Charbel, Georgy, Smitha R., Partridge, Darren, Auden, Alana, Srivastava, Seema, Wilanowski, Tomasz, Jane, Stephen M.

“…The skin barrier is critical for mammalian survival in the terrestrial environment, affording protection against fluid loss, microbes, toxins, and UV exposure…”
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The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity by Boglev, Yeliz, Wilanowski, Tomasz, Caddy, Jacinta, Parekh, Vishwas, Auden, Alana, Darido, Charbel, Hislop, Nikki R., Cangkrama, Michael, Ting, Stephen B., Jane, Stephen M.

“…The Grainy head-like 3 (Grhl3) gene encodes a transcription factor that plays essential roles in epidermal morphogenesis during embryonic development, with…”
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Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis by Goldie, Stephen J., Cottle, Denny L., Tan, Fiona H., Roslan, Suraya, Srivastava, Seema, Brady, Rhys, Partridge, Darren D., Auden, Alana, Smyth, Ian M., Jane, Stephen M., Dworkin, Sebastian, Darido, Charbel

“…Identifying soluble factors that influence epidermal integrity is critical for the development of preventative and therapeutic strategies for disorders such as…”
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Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure by Carpinelli, Marina R, de Vries, Michael E, Auden, Alana, Butt, Tariq, Deng, Zihao, Partridge, Darren D, Miles, Lee B, Georgy, Smitha R, Haigh, Jody J, Darido, Charbel, Brabletz, Simone, Brabletz, Thomas, Stemmler, Marc P, Dworkin, Sebastian, Jane, Stephen M

“…Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like ( )…”
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Author Correction: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells by Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M., Curtis, David J.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21688-1…”
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Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure by Deng, Zihao, Carpinelli, Marina R., Butt, Tariq, Magor, Graham W., Zhao, Peinan, Gillinder, Kevin R., Perkins, Andrew C., Jane, Stephen M.

“…Neural tube closure in vertebrates is achieved through a highly dynamic and coordinated series of morphogenic events involving neuroepithelium, surface…”
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Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells by Tremblay, Cedric S., Saw, Jesslyn, Chiu, Sung Kai, Wong, Nicholas C., Tsyganov, Kirill, Ghotb, Sarah, Graham, Alison N., Yan, Feng, Guirguis, Andrew A., Sonderegger, Stefan E., Lee, Nicole, Kalitsis, Paul, Reynolds, John, Ting, Stephen B., Powell, David R., Jane, Stephen M., Curtis, David J.

“…Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an important source of relapse…”
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A capability framework to inform the fundamental requirements for clinical trial unit development, growth and long term success in outer metropolitan and rural areas by Woollett, Anne, Duncan, Jhodie, Voskoboynik, Mark, Shackleton, Mark, Dooley, Michael, Blum, Robert, McPhee, Narelle, Wright, Tricia, Wong, Zee Wan, Dixon, Jacqueline, Jane, Stephen M.

“…Participation in clinical trials is linked to improved patient outcomes. Despite this, most trial participants either reside in, or are treated in metropolitan…”
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Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency by Conway, Ashlee J, Brown, Fiona C, Hortle, Elinor J, Burgio, Gaetan, Foote, Simon J, Morton, Craig J, Jane, Stephen M, Curtis, David J

“…In this study, we performed a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate…”
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