Rheological properties of blood in multiple myeloma patients

Rheological properties of blood in multiple myeloma patients

Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely studied. Hem...

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Bibliographic Details
Published in:Scientific reports Vol. 14; no. 1; p. 4260
Main Authors: Ptaszek, Bartłomiej, Podsiadło, Szymon, Jandziś, Zuzanna, Teległów, Aneta, Piotrowska, Anna, Jurczyszyn, Artur, Czerwińska-Ledwig, Olga
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 21-02-2024
Nature Publishing Group
Nature Portfolio
Subjects:
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692/4028
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Blood
Blood circulation
Blood rheology
Carbon dioxide
Cell aggregation
Deformability
Erythrocytes
Hematology
Humanities and Social Sciences
Malignancy
Morphology
multidisciplinary
Multiple myeloma
Red blood cell
Red blood cell aggregation
Red blood cell deformability
Rheology
Science
Science (multidisciplinary)
Red blood cell
Blood rheology
Red blood cell deformability
Multiple myeloma
Red blood cell aggregation
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Summary:Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely studied. Hemorheology includes the study of measuring the deformability and aggregation of erythrocytes, blood viscosity, and sedimentation rate. The degree of deformability of blood cells is necessary to maintain proper vital functions. Proper deformability of red blood cells ensures proper blood circulation, tissue oxidation and carbon dioxide uptake. The aim of the study was to compare morphology and blood rheology parameters in patients with MM and healthy individuals. The study included 33 patients with MM, and 33 healthy subjects of the same age. The hematological blood parameters were evaluated using ABX MICROS 60 hematology analyzer. The LORCA Analyzer to study erythrocyte aggregation and deformability. Patients with MM had lower red blood cells count (RBC) (9.11%) (p < 0.001) and half time of total aggregation (T1/2) (94.29%) (p < 0.001) values and higher mean corpuscular volume (MCV) (5.50%) (p < 0.001), aggregation index (AI) (68.60%) (p < 0.001), total extent of aggregation (AMP) (87.92%) (p < 0.001) values than the healthy control group. Aggregation in patients with MM is different compared to healthy individuals. It was observed that the percentage of cell aggregation is almost 50% higher than in the control group. The study of morphology, aggregation and deformability of erythrocytes in patients with suspected MM may be helpful in making clinical decisions.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-54947-4