Search Results - "Janda, K.D"

Effective active vaccination against methamphetamine in female rats by Nguyen, J.D, Bremer, P.T, Hwang, C.S, Vandewater, S.A, Collins, K.C, Creehan, K.M, Janda, K.D, Taffe, M.A

“…Highlights • Active immunization produces antibodies which can sequester drug in the blood. • Such anti-drug immunotherapy has not been broadly tested in…”
Get full text

Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats by Miller, M.L, Aarde, S.M, Moreno, A.Y, Creehan, K.M, Janda, K.D, Taffe, M.A

“…Highlights • Methamphetamine addiction has no currently approved treatment medications. • Vaccination produces antibodies which can sequester drug in the…”
Get full text

Soluble Polymers as Scaffolds for Recoverable Catalysts and Reagents by Dickerson, Tobin J, Reed, Neal N, Janda, Kim D

“…In recent years, the use of soluble polymer-supported reagents and catalysts has gained significant attention as an alternative to traditional solid-phase…”
Get full text

Antibody Catalysis of the Oxidation of Water by Wentworth, Paul, Jones, Lyn H., Wentworth, Anita D., Zhu, Xueyong, Larsen, Nicholas A., Wilson, Ian A., Xu, Xin, Goddard, William A., Janda, Kim D., Eschenmoser, Albert, Lerner, Richard A.

“…Recently we reported that antibodies can generate hydrogen peroxide (H2O 2) from singlet molecular oxygen (1O 2 *). We now show that this process is catalytic,…”
Get full text

Crystal Structures of a Quorum-Quenching Antibody by Debler, E.W., Kaufmann, G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., Wilson, I.A., /Scripps Res. Inst. /Skaggs Inst. /WIRM, La Jolla

“…A large number of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quorum sensing, which is a population…”
Get full text

Synthesis and Catalytic Antibody Functionalization of Dendrimers by Córdova, Armando, Janda, Kim D.

“…Antibody 38C2 catalyzed a retro-aldol process upon dendritic modified aliphatic polyesters. This catalytic system was studied in detail and displayed rate…”
Get full text

Complete Reaction Cycle of a Cocaine Catalytic Antibody at Atomic Resolution by Zhu, Xueyong, Dickerson, Tobin J., Rogers, Claude J., Kaufmann, Gunnar F., Mee, Jenny M., McKenzie, Kathleen M., Janda, Kim D., Wilson, Ian A.

“…Antibody 7A1 hydrolyzes cocaine to produce nonpsychoactive metabolites ecgonine methyl ester and benzoic acid. Crystal structures of 7A1 Fab′ and six complexes…”
Get full text

Toward Cocaine Esterase Therapeutics by Rogers, Claude J, Mee, Jenny M, Kaufmann, Gunnar F, Dickerson, Tobin J, Janda, Kim D

“…Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and…”
Get full text

A Cofactor Approach to Copper-Dependent Catalytic Antibodies by Nicholas, Kenneth M., Wentworth, Paul, Harwig, Curtis W., Wentworth, Anita D., Shafton, Asher, Janda, Kim D.

“…A strategy for the preparation of semisynthetic copper(II)-based catalytic metalloproteins is described in which a metal-binding bis-imidazole cofactor is…”
Get full text

Expression and characterization of a humanized cocaine-binding antibody by Redwan, El-Rashdy M., Larsen, Nicholas A., Zhou, Bin, Wirsching, Peter, Janda, Kim D., Wilson, Ian A.

“…The murine immunoglobulin G (IgG) cocaine‐binding monoclonal antibody (mAb), GNC92H2, is notable for its exquisite specificity for cocaine, as opposed to…”
Get full text

Direct Selection for Catalysis from Combinatorial Antibody Libraries Using a Boronic Acid Probe:  Primary Amide Bond Hydrolysis by Gao, Changshou, Lavey, Brian J, Lo, Chih-Hung L, Datta, Anita, Wentworth, Paul, Janda, Kim D

“…This report describes a joint hybridoma and combinatorial antibody library approach to elicit catalysts for primary amide bond hydrolysis. By immunization with…”
Get full text

S.13.01 CRF1 antagonists for anxiety by Zorrilla, E., Fekete, E., Mason, B.J., Wirsching, P., Janda, K.D., Koob, G.F.

Get full text

Advances in Antibody Catalysis of Cycloaddition Reactions by Tremblay, Martin R., Dickerson, Tobin J., Janda, Kim D.

“…Pericyclic cycloaddition reactions are among the most useful transformations available to the synthetic organic chemist. All are capable of simultaneously…”
Get full text

S.13.01 CRF 1 antagonists for anxiety by Zorrilla, E., Fekete, E., Mason, B.J., Wirsching, P., Janda, K.D., Koob, G.F.

Get full text

Evaluation of immunoglobulins from plant cells by Hein, M.B. (The Research Institute of Scripps Clinic, La Jolla, CA), Tang, Y, McLeod, D.A, Janda, K.D, Hiatt, A

“…Expression of cDNA constructs encoding full‐length mouse immunoglobulin chains with their native leader sequences or fusion constructs substituting the native…”
Get full text

New Strategies for the Design of Catalytic Antibodies by Janda, Kim D.

“…A new approach is advanced which is aimed at expanding the scope of antibody catalysis. It entails the design and synthesis of haptens that will elicit…”
Get full text

Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigations by Janda, Kim D, Ashley, Jon A, Jones, Teresa M, McLeod, Donald A, Schloeder, Diane M, Weinhouse, Michael I, Lerner, Richard A, Gibbs, Richard A, Benkovic, Patricia A

“…Antibodies have been shown to catalyze acyl-transfer reactions. The processes by which they perform such tasks have often been postulated but largely remain…”
Get full text

Nachweis chemischer Kampfstoffe anhand des Abbauprodukts Methylphosphonsäure by Ashley, Jon A., Lin, Chao-Hsiung, Wirsching, Peter, Janda, Kim D.

Get full text

Catalytic antibodies by Borman, Stu

“…A new technique has been devised by researchers for identifying catalytic antibodies that accelerate specific biochemical reactions. The technique, which took…”
Get full text