Search Results - "Janaky, Tamas"

Proteomic study of the toxic effect of oligomeric A beta 1-42 in situ prepared from 'iso-A beta 1-42' by Foldi, Istvan, Datki, Zsolt L, Szabo, Zoltan, Bozso, Zsolt, Penke, Botond, Janaky, Tamas

“…Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders even so the exact pathomechanism is still unclear. Recently, it is widely…”
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Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation by Jakus, Peter B., Sandor, Attila, Janaky, Tamas, Farkas, Viktoria

“…Rats were exposed to cold and then reacclimated at neutral temperature. Changes related to fatty acid and glucose metabolism in brown and white adipose tissues…”
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Challenges and developments in protein identification using mass spectrometry by Szabo, Zoltan, Janaky, Tamas

“…•Protein-identification strategies using mass spectrometry.•Challenges in identification of proteoforms.•“Bottom-up”, “middle-down” and “top-down” proteomics…”
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Peripheral kynurenine metabolism in focal dystonia by Hartai, Zsuzsanna, Klivenyi, Peter, Janaky, Tamas, Penke, Botond, Dux, Laszlo, Vecsei, Laszlo

“…Substantial evidence indicates that neuroactive kynurenine metabolites play a role in the normal physiology of the human brain, and are involved in the…”
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Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells by Than, Nandor G., Sumegi, Balazs, Bellyei, Szabolcs, Berki, Timea, Szekeres, Gyorgy, Janaky, Tamas, Szigeti, Andras, Bohn, Hans, Than, Gabor N.

“…The intracellular role of placental protein 17b (PP17b)/TIP47 has been controversial, because it is considered to be a protein required for mannose 6‐phosphate…”
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Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period by Tuka, Bernadett, Nyári, Aliz, Cseh, Edina Katalin, Körtési, Tamás, Veréb, Dániel, Tömösi, Ferenc, Kecskeméti, Gábor, Janáky, Tamás, Tajti, János, Vécsei, László

“…Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that…”
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Sources of Variance in Human Tear Proteomic Samples: Statistical Evaluation, Quality Control, Normalization, and Biological Insight by Bruszel, Bella, Tóth-Molnár, Edit, Janáky, Tamás, Szabó, Zoltán

“…Human tear fluid contains numerous compounds, which are present in highly variable amounts owing to the dynamic and multipurpose functions of tears. A better…”
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An Extensive Study of Phenol Red Thread as a Novel Non-Invasive Tear Sampling Technique for Proteomics Studies: Comparison with Two Commonly Used Methods by Kecskeméti, Gábor, Tóth-Molnár, Edit, Janáky, Tamás, Szabó, Zoltán

“…Tear samples are considered in recent publications as easily, noninvasively collectible information sources for precision medicine. Their complex composition…”
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The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol by Kariv-Inbal, Zehavit, Yacobson, Shiri, Berkecz, Robert, Peter, Maria, Janaky, Tamas, Lütjohann, Dieter, Broersen, Laus M, Hartmann, Tobias, Michaelson, Daniel M

“…Apolipoprotein E4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD). Epidemiological studies revealed that consumption of…”
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Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: Preparation, characterization, and in vivo evaluation by Alshweiat, Areen, Csóka, IIdikó, Tömösi, Ferenc, Janáky, Tamás, Kovács, Anita, Gáspár, Róbert, Sztojkov-Ivanov, Anita, Ducza, Eszter, Márki, Árpád, Szabó-Révész, Piroska, Ambrus, Rita

“…[Display omitted] The unique requirements of poorly water-soluble drug delivery have driven a great deal of research into new formulations and routes of…”
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A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis by Tömösi, Ferenc, Kecskeméti, Gábor, Cseh, Edina Katalin, Szabó, Elza, Rajda, Cecília, Kormány, Róbert, Szabó, Zoltán, Vécsei, László, Janáky, Tamás

“…[Display omitted] •Simultaneous and robust quantification of tryptophan and its 11 metabolites.•Derivatization; separation of analytes on pentafluorophenyl…”
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Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats by Váczi, Sándor, Barna, Lilla, Laczi, Krisztián, Tömösi, Ferenc, Rákhely, Gábor, Penke, Botond, Fülöp, Lívia, Bogár, Ferenc, Janáky, Tamás, Deli, Mária A, Mezei, Zsófia

“…Diabetes mellitus is a chronic metabolic disorder which induces endothelial dysfunction and platelet activation. Eicosanoids produced from arachidonic acid…”
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Mass spectrometry-based label free quantification of gel separated proteins by Szabo, Zoltan, Szomor, Judit Szeline, Foeldi, Istvan, Janaky, Tamas

“…Co-migrating proteins in 2D PAGE spots cause difficulties in the assignment of quantitative data obtained from the staining density of a gel spot. We present…”
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Cluster headache and kynurenines by Tuka, Bernadett, Körtési, Tamás, Nánási, Nikolett, Tömösi, Ferenc, Janáky, Tamás, Veréb, Dániel, Szok, Délia, Tajti, János, Vécsei, László

“…Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from…”
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Heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for determination of N,N-dimethyltryptamine in rat plasma and brain; Method development and application by Körmöczi, Tímea, Szabó, Írisz, Farkas, Eszter, Penke, Botond, Janáky, Tamás, Ilisz, István, Berkecz, Róbert

“…•Development of 2D-LC-HRMS/MS for determination of N,N-dimethyltryptamine (DMT) in rat plasma and brain.•New sample preparation procedure of DMT with detailed…”
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Comprehensive phospholipid and sphingomyelin profiling of different brain regions in mouse model of anxiety disorder using online two-dimensional (HILIC/RP)-LC/MS method by Berkecz, Róbert, Tömösi, Ferenc, Körmöczi, Tímea, Szegedi, Viktor, Horváth, János, Janáky, Tamás

“…•Development of novel online 2D-LC/MS method for comprehensive analysis of phospholipids and sphingomyelins in brain sample.•Profiling of PL and SM composition…”
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Inhibition of ABCG2/BCRP-mediated transport–correlation analysis of various expression systems and probe substrates by Sáfár, Zsolt, Kecskeméti, Gábor, Molnár, Judit, Kurunczi, Anita, Szabó, Zoltán, Janáky, Tamás, Kis, Emese, Krajcsi, Péter

“…BCRP / ABCG2 is a key determinant of pharmacokinetics of substrate drugs. Several BCRP substrates and inhibitors are of low passive permeability, and the…”
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Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration by Sipos, Bence, Bella, Zsolt, Gróf, Ilona, Veszelka, Szilvia, Deli, Mária A., Szűcs, Kálmán F., Sztojkov-Ivanov, Anita, Ducza, Eszter, Gáspár, Róbert, Kecskeméti, Gábor, Janáky, Tamás, Volk, Balázs, Budai-Szűcs, Mária, Ambrus, Rita, Szabó-Révész, Piroska, Csóka, Ildikó, Katona, Gábor

“…[Display omitted] •Meloxicam-loaded micelles provided efficient cellular permeability.•The micelle formulation is applicable for the nasal…”
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Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease by Hartai, Zsuzsanna, Klivenyi, Peter, Janaky, Tamas, Penke, Botond, Dux, Laszlo, Vecsei, Laszlo

“…Substantial evidence indicates that neuroactive kynurenine metabolites play a role in the normal physiology of the human brain, and are involved in the…”
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Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems by Bartos, Csilla, Ambrus, Rita, Kovács, Anita, Gáspár, Róbert, Sztojkov-Ivanov, Anita, Márki, Árpád, Janáky, Tamás, Tömösi, Ferenc, Kecskeméti, Gábor, Szabó-Révész, Piroska

“…The aim of this article was to study the trans-epithelial absorption to reach the blood and to target the brain by axonal transport using nasal formulations…”
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