Search Results - "Janakiraman, M N"

Structure-Based Design of Novel HIV Protease Inhibitors:  Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Janakiraman, Musiri N, Chong, Kong-Teck, Tomich, Paul K, Dolak, Lester A, Turner, Steve R, Strohbach, Joseph W, Lynn, Janet C, Horng, Miao-Miao, Hinshaw, Roger R, Watenpaugh, Keith D

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class by Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

“…A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this…”
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure by Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

“…Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2…”
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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

“…From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The…”
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Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-angstrom resolution: Implications for the catalytic mechanism by Janakiraman, M N, White, CL, Laver, W G, Air, G M, Luo, Ming

“…Neuraminidase is one of the two glycoprotein spikes protruding from the influenza virus membrane. We have determined by X-ray crystallography the native…”
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Mercury in organic chemistry. 34. Synthesis of vinylmercurials via mercuration of propargylic amines by Larock, R. C, Burns, L. D, Varaprath, S, Russell, C. E, Richardson, J. W, Janakiraman, M. N, Jacobson, R. A

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones by JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W

“…Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide…”
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A Sialic Acid-derived Phosphonate Analog Inhibits Different Strains of Influenza Virus Neuraminidase with Different Efficiencies by White, Clinton L., Janakiraman, Musiri N., Laver, Graeme W., Philippon, Cédric, Vasella, Andrea, Air, Gillian M., Luo, Ming

“…A phosphonate analog of N-acetyl neuraminic acid (PANA) has been designed as a potential neuraminidase (NA) inhibitor and synthesized as both the α (ePANA)…”
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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors by Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P

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Lewis basicity of silatranes and the molecular structures of EtOSi(OCH2CH2)3N, Me2O+Si(OCH2CH2)3N, and CF3CO2HetOSi(OCH2CH2)3N by GARANT, R. J, DANIELS, L. M, DAS, S. K, JANAKIRAMAN, M. N, JACOBSON, R. A, VERKADE, J. G

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Lewis basicity of silatranes and the molecular structures of EtOSi(OCH2CH2)3N, Me2O+Si(OCH2CH2)3N, and CF3CO2H.cntdot.EtOSi(OCH2CH2)3N by Garant, R. J, Daniels, L. M, Das, S. K, Janakiraman, M. N, Jacobson, R. A, Verkade, J. G

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Toward stabilizing rectangular-pyramidal geometries in non-metals: polycyclic phosphorus esters by Davis, R. V, Wintergrass, D. J, Janakiraman, M. N, Hyatt, E. M, Jacobson, R. A, Daniels, L. M, Wroblewski, A, Amma, J. Padmakumari, Das, S. K, Verkade, J. G

“…The preparation of some novel polycyclic phosphorus compounds is reported. Some chemical reactions of the compounds are discussed, and crystallographic…”
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Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-A resolution: implications for the catalytic mechanism by Janakiraman, M N, White, C L, Laver, W G, Air, G M, Luo, M

“…Neuraminidase is one of the two glycoprotein spikes protruding from the influenza virus membrane. We have determined by X-ray crystallography the native…”
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Small-ring cyclic cumulenes: synthesis and x-ray crystal structure of bis(triphenylphosphine)chloro(.eta.2-1,2,3-cyclononatriene)rhodium by Angus, Richard O, Janakiraman, Musiri N, Jacobson, Robert A, Johnson, Richard P

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones by Skulnick, H I, Johnson, P D, Aristoff, P A, Morris, J K, Lovasz, K D, Howe, W J, Watenpaugh, K D, Janakiraman, M N, Anderson, D J, Reischer, R J, Schwartz, T M, Banitt, L S, Tomich, P K, Lynn, J C, Horng, M M, Chong, K T, Hinshaw, R R, Dolak, L A, Seest, E P, Schwende, F J, Rush, B D, Howard, G M, Toth, L N, Wilkinson, K R, Romines, K R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones by Janakiraman, Musiri N., Watenpaugh, Keith D., Tomich, Paul K., Chong, Kong-Teck, Turner, Steve R., Tommasi, Ruben A., Thaisrivongs, Suvit, Strohbach, Joseph W.

“…Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide…”
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Mercury in organic chemistry. XXXIV: Synthesis of vinylmercurials via mercuration of propargylic amines by LAROCK, R. C, BURNS, L. D, VARAPRATH, S, RUSSELL, C. E, RICHARDSON, J. W. JR, JANAKIRAMAN, M. N, JACOBSON, R. A

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