Search Results - "Jan Papies"

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals by Gassen, Nils C., Papies, Jan, Bajaj, Thomas, Emanuel, Jackson, Dethloff, Frederik, Chua, Robert Lorenz, Trimpert, Jakob, Heinemann, Nicolas, Niemeyer, Christine, Weege, Friderike, Hönzke, Katja, Aschman, Tom, Heinz, Daniel E., Weckmann, Katja, Ebert, Tim, Zellner, Andreas, Lennarz, Martina, Wyler, Emanuel, Schroeder, Simon, Richter, Anja, Niemeyer, Daniela, Hoffmann, Karen, Meyer, Thomas F., Heppner, Frank L., Corman, Victor M., Landthaler, Markus, Hocke, Andreas C., Morkel, Markus, Osterrieder, Nikolaus, Conrad, Christian, Eils, Roland, Radbruch, Helena, Giavalisco, Patrick, Drosten, Christian, Müller, Marcel A.

“…Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and…”
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection by Gassen, Nils C., Niemeyer, Daniela, Muth, Doreen, Corman, Victor M., Martinelli, Silvia, Gassen, Alwine, Hafner, Kathrin, Papies, Jan, Mösbauer, Kirstin, Zellner, Andreas, Zannas, Anthony S., Herrmann, Alexander, Holsboer, Florian, Brack-Werner, Ruth, Boshart, Michael, Müller-Myhsok, Bertram, Drosten, Christian, Müller, Marcel A., Rein, Theo

“…Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified…”
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Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy by Wyler, Emanuel, Mösbauer, Kirstin, Franke, Vedran, Diag, Asija, Gottula, Lina Theresa, Arsiè, Roberto, Klironomos, Filippos, Koppstein, David, Hönzke, Katja, Ayoub, Salah, Buccitelli, Christopher, Hoffmann, Karen, Richter, Anja, Legnini, Ivano, Ivanov, Andranik, Mari, Tommaso, Del Giudice, Simone, Papies, Jan, Praktiknjo, Samantha, Meyer, Thomas F., Müller, Marcel Alexander, Niemeyer, Daniela, Hocke, Andreas, Selbach, Matthias, Akalin, Altuna, Rajewsky, Nikolaus, Drosten, Christian, Landthaler, Markus

“…Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral…”
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Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells by Papies, Jan, Sieberg, Andrea, Ritz, Daniel, Niemeyer, Daniela, Drosten, Christian, Müller, Marcel A

“…Eidolon helvum bats are reservoir hosts for highly pathogenic lyssaviruses often showing limited disease upon natural infection. An enhanced antiviral…”
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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression by Niemeyer, Daniela, Stenzel, Saskia, Veith, Talitha, Schroeder, Simon, Friedmann, Kirstin, Weege, Friderike, Trimpert, Jakob, Heinze, Julian, Richter, Anja, Jansen, Jenny, Emanuel, Jackson, Kazmierski, Julia, Pott, Fabian, Jeworowski, Lara M, Olmer, Ruth, Jaboreck, Mark-Christian, Tenner, Beate, Papies, Jan, Walper, Felix, Schmidt, Marie L, Heinemann, Nicolas, Möncke-Buchner, Elisabeth, Baumgardt, Morris, Hoffmann, Karen, Widera, Marek, Thao, Tran Thi Nhu, Balázs, Anita, Schulze, Jessica, Mache, Christin, Jones, Terry C, Morkel, Markus, Ciesek, Sandra, Hanitsch, Leif G, Mall, Marcus A, Hocke, Andreas C, Thiel, Volker, Osterrieder, Klaus, Wolff, Thorsten, Martin, Ulrich, Corman, Victor M, Müller, Marcel A, Goffinet, Christine, Drosten, Christian

“…Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more…”
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Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and SARS-CoV-2-induced inflammatory responses would be ideal candidates…”
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In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs ® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2 by Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M, Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D, Trimpert, Jakob, Müller, Marcel A

“…The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous study showed that…”
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Corrigendum: Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs ® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…[This corrects the article DOI: 10.3389/fphar.2021.757666.]…”
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Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus by Krüger, Nadine, Sauder, Christian, Hüttl, Sarah, Papies, Jan, Voigt, Kathleen, Herrler, Georg, Hardes, Kornelia, Steinmetzer, Torsten, Örvell, Claes, Drexler, Jan Felix, Drosten, Christian, Rubin, Steven, Müller, Marcel Alexander, Hoffmann, Markus

“…Bats harbor a plethora of viruses with an unknown zoonotic potential. In-depth functional characterization of such viruses is often hampered by a lack of…”
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Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses by Ehlen, Lukas, Tödtmann, Jan, Specht, Sabine, Kallies, René, Papies, Jan, Müller, Marcel A, Junglen, Sandra, Drosten, Christian, Eckerle, Isabella

“…Small mammals such as bats and rodents have been increasingly recognized as reservoirs of novel potentially zoonotic pathogens. However, few in vitro model…”
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Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells by Jan Papies, Andrea Sieberg, Daniel Ritz, Daniela Niemeyer, Christian Drosten, Marcel A. Müller

“…Eidolon helvum bats are reservoir hosts for highly pathogenic lyssaviruses often showing limited disease upon natural infection. An enhanced antiviral…”
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