Search Results - "Jan H. J. Hoeijmakers"

Cellular senescence drives age-dependent hepatic steatosis by Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana

“…The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined…”
Get full text

The central role of DNA damage in the ageing process by Schumacher, Björn, Pothof, Joris, Vijg, Jan, Hoeijmakers, Jan H. J.

“…Ageing is a complex, multifaceted process leading to widespread functional decline that affects every organ and tissue, but it remains unknown whether ageing…”
Get full text

Genome maintenance mechanisms for preventing cancer by Hoeijmakers, Jan H. J

“…The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing…”
Get full text

The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics by Llerena Schiffmacher, Diana A., Lee, Shun-Hsiao, Kliza, Katarzyna W., Theil, Arjan F., Akita, Masaki, Helfricht, Angela, Bezstarosti, Karel, Gonzalo-Hansen, Camila, van Attikum, Haico, Verlaan-de Vries, Matty, Vertegaal, Alfred C. O., Hoeijmakers, Jan H. J., Marteijn, Jurgen A., Lans, Hannes, Demmers, Jeroen A. A., Vermeulen, Michiel, Sixma, Titia K., Ogi, Tomoo, Vermeulen, Wim, Pines, Alex

“…Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of…”
Get full text

The DNA damage response to transcription stress by Lans, Hannes, Hoeijmakers, Jan H. J., Vermeulen, Wim, Marteijn, Jurgen A.

“…The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is tightly and intricately regulated. In addition, preservation of the…”
Get full text

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development by Lans, Hannes, Marteijn, Jurgen A, Schumacher, Björn, Hoeijmakers, Jan H J, Jansen, Gert, Vermeulen, Wim

“…Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms…”
Get full text

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks by Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P, Maas, Alex, Wu, Xiaoli, Moinova, Helen, Markowitz, Sanford D, Ding, Hao, Hoeijmakers, Jan H.J, Myung, Kyungjae

“…Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as…”
Get full text

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis by Robinson, Andria Rasile, Appeldoorn, Esther, Hoeijmakers, Jan H. J, Theil, Arjan F, Raams, Anja, Odijk, Hanny, Kleijer, Wim J, Meinecke, Peter, van Leeuwen, Wibeke, Lalai, Astrid S, Ahmad, Anwaar, Niedernhofer, Laura J, Vijg, Jan, Jaspers, Nicolaas G. J, Garinis, George A, Vermeulen, Wim, van der Horst, Gijsbertus T. J, Oostendorp, Roos

“…XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA lesions and cytotoxic DNA interstrand crosslinks. Mild mutations in XPF cause the…”
Get full text

Chromosomal stability and the DNA double-stranded break connection by van Gent, Dik C, Hoeijmakers, Jan H. J, Kanaar, Roland

“…Genome stability is of primary importance for the survival and proper functioning of all organisms. Double-stranded breaks in DNA are important threats to…”
Get full text

DNA damage in normally and prematurely aged mice by Maslov, Alexander Y., Ganapathi, Shireen, Westerhof, Maaike, Quispe‐Tintaya, Wilber, White, Ryan R., Van Houten, Bennett, Reiling, Erwin, Dollé, Martijn E. T., Steeg, Harry, Hasty, Paul, Hoeijmakers, Jan H. J., Vijg, Jan

“…Summary Steady‐state levels of spontaneous DNA damage, the by‐product of normal metabolism and environmental exposure, are controlled by DNA repair pathways…”
Get full text

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration by van't Sant, Lisanne J, White, Joshua J, Hoeijmakers, Jan H. J, Vermeij, Wilbert P, Jaarsma, Dick

“…Abstract Fluorescent staining of newly transcribed RNA via metabolic labelling with 5-ethynyluridine (EU) and click chemistry enables visualisation of changes…”
Get full text

Understanding nucleotide excision repair and its roles in cancer and ageing by Marteijn, Jurgen A., Lans, Hannes, Vermeulen, Wim, Hoeijmakers, Jan H. J.

“…Key Points The versatile nucleotide excision repair (NER) pathway removes helix-distorting DNA damage in a multistep 'cut and patch'-type reaction. Two damage…”
Get full text

Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology by Jaarsma, Dick, van der Pluijm, Ingrid, de Waard, Monique C, Haasdijk, Elize D, Brandt, Renata, Vermeij, Marcel, Rijksen, Yvonne, Maas, Alex, van Steeg, Harry, Hoeijmakers, Jan H J, van der Horst, Gijsbertus T J

“…Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair…”
Get full text

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC by Hoogstraten, Deborah, Bergink, Steven, Verbiest, Vincent H.M, Luijsterburg, Martijn S, Geverts, Bart, Raams, Anja, Dinant, Christoffel, Hoeijmakers, Jan H.J, Vermeulen, Wim, Houtsmuller, Adriaan B

“…To investigate how the nucleotide excision repair initiator XPC locates DNA damage in mammalian cell nuclei we analyzed the dynamics of GFP-tagged XPC…”
Get full text

Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice by Jongbloed, Franny, de Bruin, Ron W F, Pennings, Jeroen L A, Payán-Gómez, César, van den Engel, Sandra, van Oostrom, Conny T, de Bruin, Alain, Hoeijmakers, Jan H J, van Steeg, Harry, IJzermans, Jan N M, Dollé, Martijn E T

“…Ischemia-reperfusion injury (IRI) is inevitable during kidney transplantation leading to oxidative stress and inflammation. We previously reported that…”
Get full text

Premature Aging in Mice Deficient in DNA Repair and Transcription by de Boer, Jan, Andressoo, Jaan Olle, de Wit, Jan, Huijmans, Jan, Beems, Rudolph B., van Steeg, Harry, Weeda, Geert, Gijsbertus T. J. van der Horst, van Leeuwen, Wibeke, Axel P. N. Themmen, Meradji, Morteza, Jan H. J. Hoeijmakers

“…One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing…”
Get full text

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients by Ahmad, Anwaar, Enzlin, Jacqueline H, Bhagwat, Nikhil R, Wijgers, Nils, Raams, Anja, Appledoorn, Esther, Theil, Arjan F, J Hoeijmakers, Jan H, Vermeulen, Wim, J Jaspers, Nicolaas G, Schärer, Orlando D, Niedernhofer, Laura J

“…Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helix-distorting DNA lesions, such as UV-induced…”
Get full text

Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice by de Waard, Monique C., van der Pluijm, Ingrid, Zuiderveen Borgesius, Nils, Comley, Laura H., Haasdijk, Elize D., Rijksen, Yvonne, Ridwan, Yanto, Zondag, Gerben, Hoeijmakers, Jan H. J., Elgersma, Ype, Gillingwater, Thomas H., Jaarsma, Dick

“…Degeneration of motor neurons contributes to senescence-associated loss of muscle function and underlies human neurodegenerative conditions such as amyotrophic…”
Get full text

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A by Ranish, Jeffrey A, Egly, Jean-Marc, Raams, Anja, van der Spek, P J, Aebersold, Ruedi, Hoeijmakers, Jan H J, Vermeulen, Wim, Jaspers, Nicolaas G J, Coin, Frederic, Theil, Arjan, Wijgers, Nils, Hoogstraten, Deborah, Argentini, Manuela, Stefanini, Miria, Giglia-Mari, Giuseppina, Botta, Elena

“…DNA repair-deficient trichothiodystrophy (TTD) results from mutations in the XPD and XPB subunits of the DNA repair and transcription factor TFIIH. In a third…”
Get full text

Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis by Baarends, Willy M., Wassenaar, Evelyne, van der Laan, Roald, Hoogerbrugge, Jos, Sleddens-Linkels, Esther, Hoeijmakers, Jan H. J., de Boer, Peter, Grootegoed, J. Anton

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text