Antibiotic Antibiogram in Patients With Complicated Urinary Tract Infections in Nephrology Unit of South Waziristan

Antibiotic Antibiogram in Patients With Complicated Urinary Tract Infections in Nephrology Unit of South Waziristan

ObjectivesTo evaluate the antibiotic antibiogram in patients with complicated urinary tract infections (cUTIs) presenting to a Nephrology unit of South Waziristan.MethodsA cross-sectional study was conducted at the Department of Nephrology, Sholam, South Waziristan. The study included all patients w...

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Published in:Curēus (Palo Alto, CA) Vol. 14; no. 10; p. e29803
Main Authors: Kaleem Baloch, Behzad, Ali, Kifayat, Memon, Nayab, Hassan, Shahzad, Jan, Mohammad Sohail, Aziz, Jibran Bin, Kaleem, Saba
Format: Journal Article
Language:English
Published: Palo Alto Cureus Inc 01-10-2022
Cureus
Subjects:
Antibiotics
Antifungal agents
Antimicrobial agents
Bacteria
Committees
Drug resistance
E coli
Gram-negative bacteria
Gram-positive bacteria
Hospitals
Infectious Disease
Nephrology
Pathogens
Patients
Ultrasonic imaging
Urinary tract diseases
Urinary tract infections
Urine
Urogenital system
Pakistan
Waziristan Pakistan
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Summary:ObjectivesTo evaluate the antibiotic antibiogram in patients with complicated urinary tract infections (cUTIs) presenting to a Nephrology unit of South Waziristan.MethodsA cross-sectional study was conducted at the Department of Nephrology, Sholam, South Waziristan. The study included all patients who presented with cUTIs and the symptoms included urinary urgency, hematuria, dysuria, suprapubic discomfort, and increased frequency. Those patients with clinical manifestations but are on antibiotics within the past five days were excluded.ResultsA total of 158 patients were included in the study with 113 (71.5%) females and 45 (28.5%) males. A total of 95 (60%) cases had gram-negative microbes, 47 (30%) had gram-positive cocci, and 16 (10%) had candida infection. In our study, the highly prevalent uropathogenic gram-positive bacteria showed the highest sensitivity to Linezolid, Rifampicin, and Vancomycin. Methicillin-resistant staph aureus was detected in 25% of isolates. All isolates of candida were sensitive to fluconazole. Gram-negative bacteria were highly resistant to ceftazidime, cefepime, ceftriaxone, and ciprofloxacin.ConclusionThe development of bacterial resistance against multiple antibiotics is a global crisis that restricts the drug of choice for the treatment of cUTIs. In our study, we showed that overall, E.coli (gram negative) and S. Aureus (gram-positive) showed variable resistance to many antibiotics including ceftazidime, cefepime, piperacillin-tazobactam, ceftriaxone, and clindamycin.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.29803