Search Results - "Jan, Lily Y."

International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels by Huang, Fen, Wong, Xiuming, Jan, Lily Y

“…Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction,…”
Get full text

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation by Yadav, Smita, Oses-Prieto, Juan A., Peters, Christian J., Zhou, Jing, Pleasure, Samuel J., Burlingame, Alma L., Jan, Lily Y., Jan, Yuh-Nung

“…Abnormalities in dendritic spines are manifestations of several neurodevelopmental and psychiatric diseases. TAOK2 is one of the genes in the 16p11.2 locus,…”
Get full text

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons by Zubia, Mario V, Yong, Adeline J H, Holtz, Kristen M, Huang, Eric J, Jan, Yuh Nung, Jan, Lily Y

“…TMEM16F is a calcium-activated phospholipid scramblase and nonselective ion channel, which allows the movement of lipids bidirectionally across the plasma…”
Get full text

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development by Ultanir, Sila K, Yadav, Smita, Hertz, Nicholas T, Oses-Prieto, Juan A, Claxton, Suzanne, Burlingame, Alma L, Shokat, Kevan M, Jan, Lily Y, Jan, Yuh-Nung

“…Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling…”
Get full text

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis by Headland, Sarah E, Jones, Hefin R, Norling, Lucy V, Kim, Andrew, Souza, Patricia R, Corsiero, Elisa, Gil, Cristiane D, Nerviani, Alessandra, Dell'Accio, Francesco, Pitzalis, Costantino, Oliani, Sonia M, Jan, Lily Y, Perretti, Mauro

“…Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to target cells, yet…”
Get more information

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area by Wang, Tongfei A., Teo, Chin Fen, Åkerblom, Malin, Chen, Chao, Tynan-La Fontaine, Marena, Greiner, Vanille Juliette, Diaz, Aaron, McManus, Michael T., Jan, Yuh Nung, Jan, Lily Y.

“…Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of…”
Get full text

The distribution and targeting of neuronal voltage-gated ion channels by Jan, Lily Y, Lai, Helen C

“…Voltage-gated ion channels have to be at the right place in the right number to endow individual neurons with their specific character. Their biophysical…”
Get full text

Control of the Postmating Behavioral Switch in Drosophila Females by Internal Sensory Neurons by Yang, Chung-hui, Rumpf, Sebastian, Xiang, Yang, Gordon, Michael D., Song, Wei, Jan, Lily Y., Jan, Yuh-Nung

“…Mating induces changes in the receptivity and egg-laying behavior in Drosophila females, primarily due to a peptide pheromone called sex peptide which is…”
Get full text

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation by Chi, Neil C, Shaw, Robin M, De Val, Sarah, Kang, Guson, Jan, Lily Y, Black, Brian L, Stainier, Didier Y R

“…Cardiac chamber formation represents an essential evolutionary milestone that allows for the heart to receive (atrium) and pump (ventricle) blood throughout a…”
Get full text

Conduits of Life’s Spark: A Perspective on Ion Channel Research since the Birth of Neuron by Isacoff, Ehud Y., Jan, Lily Y., Minor, Daniel L.

“…Heartbeats, muscle twitches, and lightning-fast thoughts are all manifestations of bioelectricity and rely on the activity of a class of membrane proteins…”
Get full text

Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions by Shaw, Robin M., Fay, Alex J., Puthenveedu, Manojkumar A., von Zastrow, Mark, Jan, Yuh-Nung, Jan, Lily Y.

“…Gap junctions are intercellular channels that connect the cytoplasms of adjacent cells. For gap junctions to properly control organ formation and electrical…”
Get full text

Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity by Yadav, Smita, Younger, Susan H., Zhang, Linghua, Thompson-Peer, Katherine L., Li, Tun, Jan, Lily Y., Jan, Yuh Nung

“…Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While…”
Get full text

Identification of E2/E3 Ubiquitinating Enzymes and Caspase Activity Regulating Drosophila Sensory Neuron Dendrite Pruning by Kuo, Chay T., Zhu, Sijun, Younger, Susan, Jan, Lily Y., Jan, Yuh Nung

“…Ubiquitin-proteasome system (UPS) is a multistep protein degradation machinery implicated in many diseases. In the nervous system, UPS regulates remodeling and…”
Get full text

Genetic and physiologic dissection of the vertebrate cardiac conduction system by Chi, Neil C, Shaw, Robin M, Jungblut, Benno, Huisken, Jan, Ferrer, Tania, Arnaout, Rima, Scott, Ian, Beis, Dimitris, Xiao, Tong, Baier, Herwig, Jan, Lily Y, Tristani-Firouzi, Martin, Stainier, Didier Y R

“…Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood…”
Get full text

N‐linked glycosylation of Kv1.2 voltage‐gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels by Thayer, Desiree A., Yang, Shi‐Bing, Jan, Yuh Nung, Jan, Lily Y.

“…Key points Kv1.2 and related voltage‐gated potassium channels have a highly conserved N‐linked glycosylation site in the first extracellular loop, with complex…”
Get full text

Polarized Axonal Surface Expression of Neuronal KCNQ Channels Is Mediated by Multiple Signals in the KCNQ2 and KCNQ3 C-Terminal Domains by Chung, Hee Jung, Jan, Yuh Nung, Jan, Lily Y.

“…The M channels, important regulators of neuronal excitability, are voltage-gated potassium channels composed of KCNQ2-5 subunits. Mutations in KCNQ2 and KCNQ3…”
Get full text

SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling by Tuomivaara, Sami T., Teo, Chin Fen, Jan, Yuh Nung, Wiita, Arun P., Jan, Lily Y.

“…To facilitate our understanding of proteome dynamics during signaling events, robust workflows affording fast time resolution without confounding factors are…”
Get full text

Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology by Grueber, Wesley B, Ye, Bing, Yang, Chung-Hui, Younger, Susan, Borden, Kelly, Jan, Lily Y, Jan, Yuh-Nung

“…Neurons establish diverse dendritic morphologies during development, and a major challenge is to understand how these distinct developmental programs might…”
Get full text

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity by Orr, Brian O., Gorczyca, David, Younger, Meg A., Jan, Lily Y., Jan, Yuh-Nung, Davis, Graeme W.

“…The homeostatic control of presynaptic neurotransmitter release stabilizes information transfer at synaptic connections in the nervous system of organisms…”
Get full text

Tiling of the Drosophila epidermis by multidendritic sensory neurons by Grueber, Wesley B, Jan, Lily Y, Jan, Yuh Nung

“…Insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and dendritic territories are established during…”
Get full text