Search Results - "Jamora, Colin"

Epithelial decision makers: in search of the 'epimmunome' by Havran, Wendy, Hayday, Adrian, Swamy, Mahima, Jamora, Colin

“…Frequent microbial and nonmicrobial challenges to epithelial cells trigger discrete pathways, promoting molecular changes such as the secretion of specific…”
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Generation of control human iPSC line INSTEMi001-A from PBMCs of a healthy Indian donor by Patlolla, Niharika, Ponnachan, Pretty, Jamora, Colin, Abbey, Deepti

“…Human pluripotent stem cells serve as a robust model system to study disease pathogenesis in a dish and search for various targeted therapeutics. Collection of…”
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Initiation of wound healing is regulated by the convergence of mechanical and epigenetic cues by Bhatt, Tanay, Dey, Rakesh, Hegde, Akshay, Ketkar, Alhad Ashok, Pulianmackal, Ajai J, Deb, Ashim P, Rampalli, Shravanti, Jamora, Colin

“…Wound healing in the skin is a complex physiological process that is a product of a cell state transition from homeostasis to repair. Mechanical cues are…”
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Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival by Zaarour, Rania F, Azakir, Bilal, Hajam, Edries Y, Nawafleh, Husam, Zeinelabdin, Nagwa A, Engelsen, Agnete S T, Thiery, Jérome, Jamora, Colin, Chouaib, Salem

“…Programmed cell death or type I apoptosis has been extensively studied and its contribution to the pathogenesis of disease is well established. However,…”
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Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment by Lee, Dai-Jen, Du, Fei, Chen, Shih-Wei, Nakasaki, Manando, Rana, Isha, Shih, Vincent F.S., Hoffmann, Alexander, Jamora, Colin

“…The inflammasome is a complex of proteins that has a critical role in mounting an inflammatory response in reply to a harmful stimulus that compromises the…”
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Links between signal transduction, transcription and adhesion in epithelial bud development by Fuchs, Elaine, Jamora, Colin, DasGupta, Ramanuj, Kocieniewski, Pawel

“…The morphogenesis of organs as diverse as lungs, teeth and hair follicles is initiated by a downgrowth from a layer of epithelial stem cells. During follicular…”
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Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8 by Bhatt, Tanay, Bhosale, Aishwarya, Bajantri, Bhavya, Mathapathi, Mruthyunjaya Swamy, Rizvi, Abrar, Scita, Giorgio, Majumdar, Amitabha, Jamora, Colin

“…Antimicrobial peptides (AMPs) are the body’s natural innate immune defense against a spectrum of pathogens and can also modulate cell proliferation,…”
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Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells by Lee, Pedro, Gund, Rupali, Dutta, Abhik, Pincha, Neha, Rana, Isha, Ghosh, Subhasri, Witherden, Deborah, Kandyba, Eve, MacLeod, Amanda, Kobielak, Krzysztof, Havran, Wendy L, Jamora, Colin

“…The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by…”
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The expanding impact of T-regs in the skin by Hajam, Edries Yousaf, Panikulam, Patricia, Chu, Chung-Ching, Jayaprakash, Haarshadri, Majumdar, Amitabha, Jamora, Colin

“…As the interface between the body and the environment, the skin functions as the physical barrier against external pathogens and toxic agents. In addition, the…”
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Dynamic expression of epidermal caspase 8 simulates a wound healing response by Jamora, Colin, Lee, Pedro, Lee, Dai-Jen, Chan, Carol, Chen, Shih-Wei, Ch'en, Irene

“…Tissue homeostasis and regeneration are regulated by an intricate balance of seemingly competing processes-proliferation versus differentiation, and cell death…”
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The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis by Nakasaki, Manando, Hwang, Yongsung, Xie, Yun, Kataria, Sunny, Gund, Rupali, Hajam, Edries Y., Samuel, Rekha, George, Renu, Danda, Debashish, M.J., Paul, Nakamura, Tomoyuki, Shen, Zhouxin, Briggs, Steve, Varghese, Shyni, Jamora, Colin

“…Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix (ECM) compromises tissue function. Although the underlying mechanisms…”
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Vaccination-based immunotherapy to target profibrotic cells in liver and lung by Sobecki, Michal, Chen, Jing, Krzywinska, Ewelina, Nagarajan, Shunmugam, Fan, Zheng, Nelius, Eric, Monné Rodriguez, Josep M, Seehusen, Frauke, Hussein, Amro, Moschini, Greta, Hajam, Edries Y, Kiran, Ravi, Gotthardt, Dagmar, Debbache, Julien, Badoual, Cécile, Sato, Tatsuyuki, Isagawa, Takayuki, Takeda, Norihiko, Tanchot, Corinne, Tartour, Eric, Weber, Achim, Werner, Sabine, Loffing, Johannes, Sommer, Lukas, Sexl, Veronika, Münz, Christian, Feghali-Bostwick, Carol, Pachera, Elena, Distler, Oliver, Snedeker, Jess, Jamora, Colin, Stockmann, Christian

“…Fibrosis is the final path of nearly every form of chronic disease, regardless of the pathogenesis. Upon chronic injury, activated, fibrogenic fibroblasts…”
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TANGO1 inhibitors reduce collagen secretion and limit tissue scarring by Raote, Ishier, Rosendahl, Ann-Helen, Häkkinen, Hanna-Maria, Vibe, Carina, Küçükaylak, Ismail, Sawant, Mugdha, Keufgens, Lena, Frommelt, Pia, Halwas, Kai, Broadbent, Katrina, Cunquero, Marina, Castro, Gustavo, Villemeur, Marie, Nüchel, Julian, Bornikoel, Anna, Dam, Binita, Zirmire, Ravindra K., Kiran, Ravi, Carolis, Carlo, Andilla, Jordi, Loza-Alvarez, Pablo, Ruprecht, Verena, Jamora, Colin, Campelo, Felix, Krüger, Marcus, Hammerschmidt, Matthias, Eckes, Beate, Neundorf, Ines, Krieg, Thomas, Malhotra, Vivek

“…Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread…”
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Poly (A) binding protein 2 is critical for stem cell differentiation during regeneration in the planarian Schmidtea mediterranea by Mukundan, Namita, Hariharan, Nivedita, Sasidharan, Vidyanand, Lakshmanan, Vairavan, Palakodeti, Dasaradhi, Jamora, Colin

“…Post-transcriptional regulation has emerged as a key mechanism for regulating stem cell renewal and differentiation, which is essential for understanding…”
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Hair Follicle Grafting Therapy Promotes Re-Emergence of Critical Skin Components in Chronic Nonhealing Wounds by Saha, Dyuti, Thannimangalath, Sujaya, Budamakuntla, Leelavathy, Loganathan, Eswari, Jamora, Colin

“…An exploding public health crisis is the exponential growth in the incidence of chronic nonhealing ulcers associated with diseases such as diabetes. Various…”
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Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption by Bhatt, Tanay, Dam, Binita, Khedkar, Sneha Uday, Lall, Sahil, Pandey, Subhashini, Kataria, Sunny, Ajnabi, Johan, Gulzar, Shah-E-Jahan, Dias, Paul M, Waskar, Morris, Raut, Janhavi, Sundaramurthy, Varadharajan, Vemula, Praveen Kumar, Ghatlia, Naresh, Majumdar, Amitabha, Jamora, Colin

“…The continual emergence of SARS-CoV-2 variants threatens to compromise the effectiveness of worldwide vaccination programs, and highlights the need for…”
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Critical Role for Mast Cell Stat5 Activity in Skin Inflammation by Ando, Tomoaki, Xiao, Wenbin, Gao, Peisong, Namiranian, Siavash, Matsumoto, Kenji, Tomimori, Yoshiaki, Hong, Hong, Yamashita, Hirotaka, Kimura, Miho, Kashiwakura, Jun-ichi, Hata, Tissa R., Izuhara, Kenji, Gurish, Michael F., Roers, Axel, Rafaels, Nicholas M., Barnes, Kathleen C., Jamora, Colin, Kawakami, Yuko, Kawakami, Toshiaki

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin…”
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Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis by Baldo, Cristiani, Jamora, Colin, Yamanouye, Norma, Zorn, Telma M, Moura-da-Silva, Ana M

“…Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of…”
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Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8 by Li, Christopher, Lasse, Samuel, Lee, Pedro, Nakasaki, Manando, Chen, Shih-Wei, Yamasaki, Kenshi, Gallo, Richard L., Jamora, Colin, Fuchs, Elaine

“…Atopic dermatitis is an inflammatory skin disease that affects approximately 20% of children worldwide. Left untreated, the barrier function of the skin is…”
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HIF isoforms in the skin differentially regulate systemic arterial pressure by Cowburn, Andrew S., Takeda, Norihiko, Boutin, Adam T., Kim, Jung-Whan, Sterling, Jane C., Nakasaki, Manando, Southwood, Mark, Goldrath, Ananda W., Jamora, Colin, Nizet, Victor, Chilvers, Edwin R., Johnson, Randall S.

“…Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor…”
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