Search Results - "Jaminon, Armand M"
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Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease
Published in Scientific reports (20-04-2020)“…Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires carboxylation by vitamin K to exert calcification inhibition…”
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Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice
Published in Scientific reports (07-03-2019)“…Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate…”
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Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study
Published in PloS one (24-02-2021)“…Patients with chronic kidney disease (CKD) suffer from vitamin K deficiency and are at high risk of vascular calcification (VC) and premature death. We…”
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Microvesicle-Mediated Tissue Regeneration Mitigates the Effects of Cellular Ageing
Published in Cells (Basel, Switzerland) (23-06-2023)“…Extracellular vesicles (EVs), comprising microvesicles (MVs) and exosomes (Exos), are membranous vesicles secreted by cells which mediate the repair of…”
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Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy
Published in Frontiers in physiology (12-01-2022)“…Accurate information on vascular smooth muscle cell (VSMC) content, orientation, and distribution in blood vessels is indispensable to increase understanding…”
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The Maastricht Acquisition Platform for Studying Mechanisms of Cell–Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease
Published in Biomedicines (25-07-2023)“…Current management guidelines for ascending thoracic aortic aneurysms (aTAA) recommend intervention once ascending or sinus diameter reaches 5–5.5 cm or shows…”
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Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity
Published in Cells (Basel, Switzerland) (16-08-2021)“…Vascular calcification is an active process that increases cardiovascular disease (CVD) risk. There is still no consensus on an appropriate biomarker for…”
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The BioHybrid Assay: A Novel Method for Determining Calcification Propensity
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…Vascular calcification is an active pathological process, characterised by cellular dysregulation and subsequent changes to the extracellular environment. In…”
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Does statins promote vascular calcification in chronic kidney disease?
Published in European journal of clinical investigation (01-02-2017)“…Background In end‐stage renal disease (ESRD), coronary artery calcification (CAC) and inflammation contribute to cardiovascular disease (CVD). Statins do not…”
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YI 1.7 Transmural Quantification of Murine Vascular Smooth Muscle Cell Density Distribution from 3D Microscopy Images
Published in Artery research (01-12-2020)“…Purpose Investigating the biomechanical role of smooth muscle cells (SMCs) in arteries requires knowledge of their structural distributions. Compared to…”
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Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
Published in Clinical and translational medicine (01-02-2022)“…Rationale Vascular calcification is a prominent feature of late‐stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events…”
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Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability
Published in European heart journal open (01-09-2021)“…Abstract Aims Vascular calcification is a hallmark of atherosclerotic burden and can predict the cardiovascular outcome. Vitamin K antagonists (VKA) are widely…”
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