Search Results - "Jamieson, Stephen"

Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer by Hunter, Francis W., Barker, Hilary R., Lipert, Barbara, Rothé, Françoise, Gebhart, Géraldine, Piccart-Gebhart, Martine J., Sotiriou, Christos, Jamieson, Stephen M. F.

“…The HER2-targeted antibody–drug conjugate trastuzumab emtansine (T-DM1) is approved for the treatment of metastatic, HER2-positive breast cancer after prior…”
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The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice by Merry, Troy L., Brooks, Anna E. S., Masson, Stewart W., Adams, Shannon E., Jaiswal, Jagdish K., Jamieson, Stephen M. F., Shepherd, Peter R.

“…Background and objectives Excessive adipose tissue macrophage accumulation in obesity has been implicated in mediating inflammatory responses that impair…”
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Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8‑Hydroxyquinoline Anticancer Agents by Kubanik, Mario, Holtkamp, Hannah, Söhnel, Tilo, Jamieson, Stephen M. F, Hartinger, Christian G

“…8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties, which make them an ideal bioactive building block in the development…”
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From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents by Lam, Nelson Y. S, Truong, Dianna, Burmeister, Hilke, Babak, Maria V, Holtkamp, Hannah U, Movassaghi, Sanam, Ayine-Tora, Daniel Moscoh, Zafar, Ayesha, Kubanik, Mario, Oehninger, Luciano, Söhnel, Tilo, Reynisson, Jóhannes, Jamieson, Stephen M. F, Gaiddon, Christian, Ott, Ingo, Hartinger, Christian G

“…The promise of the metal­(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic…”
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Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery by Kanamala, Manju, Palmer, Brian D, Jamieson, Stephen Mf, Wilson, William R, Wu, Zimei

“…pH-sensitive liposomes (pSL) have emerged as promising nanocarriers due to their endo/lysosome-escape abilities, however, their pH sensitivity is compromised…”
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Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect by Yang, Mimi M., Yarragudi, Sasi Bhushan, Jamieson, Stephen M. F., Tang, Mingtan, Wilson, William R., Wu, Zimei

“…While delivery of chemotherapeutics to cancer cells by nanomedicines can improve therapeutic outcomes, many fail due to the low drug loading (DL), poor…”
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Mustards-Derived Terpyridine–Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination by Adams, Muneebah, Sullivan, Matthew P, Tong, Kelvin K. H, Goldstone, David C, Hanif, Muhammad, Jamieson, Stephen M. F, Hartinger, Christian G

“…The development of bifunctional platinum complexes with the ability to interact with DNA via different binding modes is of interest in anticancer metallodrug…”
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Targeting growth hormone in cancer: future perspectives by Wang, Yue, Jamieson, Stephen M F, Perry, Jo K

“…Decades of published research support a role for growth hormone (GH) in cancer. Accordingly, there is increasing interest in targeting GH in oncology, with GH…”
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A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor by Hanif, Muhammad, Arshad, Jahanzaib, Astin, Jonathan W., Rana, Zohaib, Zafar, Ayesha, Movassaghi, Sanam, Leung, Euphemia, Patel, Kamal, Söhnel, Tilo, Reynisson, Jóhannes, Sarojini, Vijayalekshmi, Rosengren, Rhonda J., Jamieson, Stephen M. F., Hartinger, Christian G.

“…The combination of more than one bioactive moiety in a multitargeted anticancer agent may result in synergistic activity of its components. Using this concept,…”
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Growth hormone receptor antagonism suppresses tumour regrowth after radiotherapy in an endometrial cancer xenograft model by Evans, Angharad, Jamieson, Stephen M.F, Liu, Dong-Xu, Wilson, William R, Perry, Jo K

“…Highlights • The GH receptor is a potential target for anticancer therapy. • We demonstrate that pegvisomant combined with radiation significantly delayed the…”
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Anti‐Inflammatory Oxicams as Multi‐donor Ligand Systems: pH‐ and Solvent‐Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os by Aman, Farhana, Hanif, Muhammad, Kubanik, Mario, Ashraf, Adnan, Söhnel, Tilo, Jamieson, Stephen M. F., Siddiqui, Waseeq Ahmad, Hartinger, Christian G.

“…The nitrogen‐ and sulfur‐containing 1,2‐benzothiazines meloxicam and piroxicam are widely used as nonsteroidal anti‐inflammatory drugs. Intrigued by the…”
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Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides by Bonnet, Muriel, Hong, Cho Rong, Wong, Way Wua, Liew, Lydia P, Shome, Avik, Wang, Jingli, Gu, Yongchuan, Stevenson, Ralph J, Qi, Wen, Anderson, Robert F, Pruijn, Frederik B, Wilson, William R, Jamieson, Stephen M. F, Hicks, Kevin O, Hay, Michael P

“…Innovations in the field of radiotherapy such as stereotactic body radiotherapy, along with the advent of radio-immuno-oncology, herald new opportunities for…”
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Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models by Lee, Tet Woo, Singleton, Dean C., Harms, Julia K., Lu, Man, McManaway, Sarah P., Lai, Amy, Tercel, Moana, Pruijn, Frederik B., Macann, Andrew M. J., Hunter, Francis W., Wilson, William R., Jamieson, Stephen M. F.

“…Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target…”
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Genetic Code Expansion Enables Site-Specific PEGylation of a Human Growth Hormone Receptor Antagonist through Click Chemistry by Tamshen, Kyle, Wang, Yue, Jamieson, Stephen M. F, Perry, Jo K, Maynard, Heather D

“…Regulation of human growth hormone (GH) signaling has important applications in the remediation of several diseases including acromegaly and cancer. Growth…”
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Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility by Tremlett, William D.J., Tong, Kelvin K.H., Steel, Tasha R., Movassaghi, Sanam, Hanif, Muhammad, Jamieson, Stephen M.F., Söhnel, Tilo, Hartinger, Christian G.

“…Organometallic compounds based on bioactive ligand systems have shown promising antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives…”
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Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules by Lee, Betty Y. T, Sullivan, Matthew P, Yano, Ena, Tong, Kelvin K. H, Hanif, Muhammad, Kawakubo-Yasukochi, Tomoyo, Jamieson, Stephen M. F, Soehnel, Tilo, Goldstone, David C, Hartinger, Christian G

“…N-Heterocyclic carbene (NHC) ligands are widely investigated in medicinal inorganic chemistry. Here, we report the preparation and characterization of a series…”
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Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens by Lee, Tet Woo, Hunter, Francis W., Tsai, Peter, Print, Cristin G., Wilson, William R., Jamieson, Stephen M. F.

“…Transplantable in vivo CRISPR/Cas9 knockout screens, in which cells are edited in vitro and inoculated into mice to form tumours, allow evaluation of gene…”
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Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand by Hanif, Muhammad, Moon, Sally, Sullivan, Matthew P., Movassaghi, Sanam, Kubanik, Mario, Goldstone, David C., Söhnel, Tilo, Jamieson, Stephen M.F., Hartinger, Christian G.

“…With the aim of increasing the accumulation of Ru anticancer agents in the tumor, a targeted delivery strategy based on a maleimide anchor for the biological…”
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In vitro and in vivo accumulation of the anticancer Ru complexes [RuII(cym)(HQ)Cl] and [RuII(cym)(PCA)Cl]Cl by Riisom, Mie, Morrow, Stuart J., Herbert, Caitlin D., Tremlett, William D. J., Astin, Jonathan W., Jamieson, Stephen M. F., Hartinger, Christian G.

“…The cellular accumulation and the underlying mechanisms for the two ruthenium-based anticancer complexes [Ru II (cym)(HQ)Cl] 1 (cym = η 6 - p -cymene, HQ =…”
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Impact of Coordination Mode and Ferrocene Functionalization on the Anticancer Activity of N‑Heterocyclic Carbene Half-Sandwich Complexes by Tong, Kelvin K. H., Riisom, Mie, Leung, Euphemia, Hanif, Muhammad, Söhnel, Tilo, Jamieson, Stephen M. F., Hartinger, Christian G.

“…The substitution of phenyl rings in established drugs with ferrocenyl moieties has been reported to yield compounds with improved biological activity and…”
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