Search Results - "Jamie Horn"

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects by Ye, Qing, Zhang, Yinan, Cao, Yanan, Wang, Xiachang, Guo, Yubin, Chen, Jing, Horn, Jamie, Ponomareva, Larissa V, Chaiswing, Luksana, Shaaban, Khaled A, Wei, Qiou, Anderson, Bradley D, St Clair, Daret K, Zhu, Haining, Leggas, Markos, Thorson, Jon S, She, Qing-Bai

“…Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor…”
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Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent by Hedrick, Sidnee L, Luo, Dan, Kaska, Sophia, Niloy, Kumar Kulldeep, Jackson, Karen, Sarma, Rupam, Horn, Jamie, Baynard, Caroline, Leggas, Markos, Butelman, Eduardo R, Kreek, Mary Jeanne, Prisinzano, Thomas E

“…Abstract Background One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute…”
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Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice by Dunn, Amelia D, Robinson, Shivon A, Nwokafor, Chiso, Estill, Molly, Ferrante, Julia, Shen, Li, Lemchi, Crystal O, Creus-Muncunill, Jordi, Ramirez, Angie, Mengaziol, Juliet, Brynildsen, Julia K, Leggas, Mark, Horn, Jamie, Ehrlich, Michelle E, Blendy, Julie A

“…Infants exposed to opioids are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including…”
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The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination[S] by Wang, Yuhuan, Liu, Xiaoxi, Pijut, Sonja S., Li, Jianing, Horn, Jamie, Bradford, Emily M., Leggas, Markos, Barrett, Terrence A., Graf, Gregory A.

“…Previous studies suggest an interdependent relationship between liver and intestine for cholesterol elimination from the body. We hypothesized that a…”
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Validated LC-MS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate： Pharmacokinetic application by Ahmed, Tamer A., Horn, Jamie, Hayslip, John, Leggas, Markos

“…Simvastatin （SIM） is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor widely used in hyperlipidemia therapy. SIM has recently been studied for its…”
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Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma by Horn, Jamie, Jordan, Sherri L., Song, Lin, Roberts, Michael J., Anderson, Bradley D., Leggas, Markos

“…A method for the quantitation of DB-67 ((20 S)-10-hydroxy-7- tert-butyldimethylsilylcamptothecin) lactone and carboxylate in mouse plasma has been developed,…”
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One electron oxidation of 3-methylcholanthrene: A chemical model for its mechanism of carcinogenesis by Lehner, Andreas F., Horn, Jamie, Flesher, James W.

“…One electron transfer oxidation has long been proposed as a route to the ultimate electrophilic and carcinogenic metabolites of both methylated and…”
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Carcinogenicity of 1-Hydroxy-3-methylcholanthrene and Its Electrophilic Sulfate Ester 1-Sulfooxy-3-methylcholanthrene in Sprague-Dawley Rats by Flesher, James W., Horn, Jamie, Lehner, Andreas F.

“…Previous experiments have demonstrated that the carcinogen 1-hydroxy-3-methylcholanthrene is a metabolite of 3-methylcholanthrene…”
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Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 by Shaaban, Khaled A, Elshahawi, Sherif I, Wang, Xiachang, Horn, Jamie, Kharel, Madan K, Leggas, Markos, Thorson, Jon S

“…Actinomadura melliaura ATCC 39691, a strain isolated from a soil sample collected in Bristol Cove, California, is a known producer of the…”
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9-Sulfooxymethylanthracene Is an Ultimate Electrophilic and Carcinogenic Form of 9-Hydroxymethylanthracene by Flesher, James W., Horn, Jamie, Lehner, Andreas F.

“…The role of electrophilic hydroxymethyl sulfate esters in the metabolic activation, DNA-damage, mutagenicity, and complete carcinogenicity of polycyclic…”
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OleD Loki as a Catalyst for Hydroxamate Glycosylation by Hughes, Ryan R., Shaaban, Khaled A., Ponomareva, Larissa V., Horn, Jamie, Zhang, Chunhui, Zhan, Chang‐Guo, Voss, S. Randal, Leggas, Markos, Thorson, Jon S.

“…Herein we describe the ability of the permissive glycosyltransferase (GT) OleD Loki to convert a diverse set of >15 histone deacetylase (HDAC) inhibitors…”
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Abstract 2628: Mithramycin analogs with reduced toxicity for EWS-FLI1 targeting by Eckenrode, Joseph, Horn, Jamie, Chen, Jhong-Min, Rohr, Jurgen, Leggas, Markos

“…Abstract Introduction: EWS-FLI1 and related chromosomal translocations are prevalent in Ewing sarcoma and play a major role in modulating oncogenic…”
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Enzymatic Methylation and Structure-Activity-Relationship Studies on Polycarcin V, a Gilvocarcin-Type Antitumor Agent by Chen, Jhong-Min, Shepherd, Micah D., Horn, Jamie, Leggas, Markos, Rohr, Jürgen

“…Polycarcin V, a polyketide natural product of Streptomyces polyformus, was chosen to study structure–activity relationships of the gilvocarcin group of…”
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An HPLC assay for the lipophilic camptothecin analog AR-67 carboxylate and lactone in human whole blood by Tsakalozou, Eleftheria, Horn, Jamie, Leggas, Mark

“…AR‐67 (7‐t‐butyldimethylsilyl‐10‐hydroxycamptothecin, DB‐67) is a camptothecin analog currently in early stage clinical trials. The lactone moiety of…”
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Metabolic Pathways of the Camptothecin Analog AR-67 by HORN, Jamie, MILEWSKA, Marta, ARNOLD, Susanne M, LEGGAS, Markos

“…7-tert-Butyldimethylsilyl-10-hydroxycamptothecin (AR-67; also known as DB-67) is a novel lipophilic camptothecin analog in early-phase anticancer clinical…”
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Abstract C216: Small molecule antitubulin drugs that evade multiple drug resistance mechanisms by Leggas, Markos, Tsakalozou, Eleftheria, Ahmed, Tamer, Kuo, Kuei-Ling, Horn, Jamie, Penthala, Narsimha, Crooks, Peter

“…Abstract Background: A new library of small molecules with structural features resembling combretastatin analogs was synthesized and two analogues were chosen…”
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Validated LCâMS/MS method for simultaneous determination of SIM and its acid form in human plasma and cell lysate: Pharmacokinetic application by Tamer A. Ahmed, Jamie Horn, John Hayslip, Markos Leggas

“…Simvastatin (SIM) is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor widely used in hyperlipidemia therapy. SIM has recently been studied for its…”
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Formation of radical cations in a model for the metabolism of aromatic hydrocarbons by Lehner, Andreas F., Horn, Jamie, Flesher, James W.

“…To test the hypothesis that electrophilic radical cations are the major ultimate electrophilic and carcinogenic forms of benz[ a]anthracene (BA), dibenz[ a,…”
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Mass spectrometric analysis of 7-sulfoxymethyl-12-methylbenz[a]anthracene and related electrophilic polycyclic aromatic hydrocarbon metabolites by Lehner, Andreas F., Horn, Jamie, Flesher, James W.

“…The Meso‐region theory of polycyclic aromatic hydrocarbon (PAH) carcinogenesis predicts that the development of pronounced carcinogenicity depends on the…”
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Formation of Benzylic−DNA Adducts Resulting from 7,12-Dimethylbenz[a]anthracene in Vivo by Ravi Kumar, M. N. V, Vadhanam, Manicka V, Horn, Jamie, Flesher, James W, Gupta, Ramesh C

“…Studies were undertaken to determine the formation of benzylic−DNA adducts in rats administered 7,12-dimethylbenz[a]anthracene (DMBA) and its meso-region…”
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