Search Results - "Jameson, J.Larry"

The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans by Ozisik, Gokhan, Achermann, John C., Jameson, J.Larry

“…Steroidogenic factor 1 is a monomeric orphan nuclear receptor and one of several hundreds of transcription factors encoded in the human genome. It regulates…”
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EGF activates highly selective estrogen-responsive reporter plasmids by an ER-independent pathway by Gehm, Barry D, McAndrews, Joanne M, Jordan, V.Craig, Jameson, J.Larry

“…Epidermal growth factor (EGF) mimics the effects of estrogen on some cells, suggesting that it may activate the estrogen receptor (ER). We examined the ability…”
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Second Zinc Finger Mutants of Thyroid Hormone Receptor Selectively Preserve DNA Binding and Heterodimerization but Eliminate Transcriptional Activation by Nagaya, Takashi, Kopp, Peter, Kitajima, Koichi, Jameson, J.Larry, Seo, Hisao

“…Transcriptional regulation by thyroid hormone is mediated through its nuclear receptors (TRs), which bind to target responsive elements as homodimers or as…”
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The Interaction of the Vitamin D Receptor with Nuclear Receptor Corepressors and Coactivators by Tagami, Tetsuya, Lutz, Ward H., Kumar, Rajiv, Jameson, J.Larry

“…The vitamin D receptor (VDR), thyroid hormone receptor (TR), and retinoic acid receptor (RAR) are ligand-dependent transcription factors that function via the…”
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Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2 by Gehm, Barry D., Levenson, Anait S., Liu, Hong, Lee, Eun-Jig, Amundsen, Beth M., Cushman, Mark, Jordan, V.Craig, Jameson, J.Larry

“…Resveratrol, a hydroxystilbene found in grapes and wine, has previously been shown to be a non-flavonoid phytoestrogen, and to act as an estrogen receptor (ER)…”
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Inherited disorders of the gonadotropin hormones by Achermann, John C, Weiss, Jeffrey, Lee, Eun-Jig, Jameson, J.Larry

“…Pulsatile GnRH acts at the GnRH receptor on gonadotropes to stimulate gonadotropin gene expression, hormone synthesis and secretion. The pituitary…”
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Presymptomatic diagnosis of X-linked adrenal hypoplasia congenita by analysis of DAX1 by Achermann, John C., Silverman, Bernard L., Habiby, Reema L., Jameson, J.Larry

“…A novel DAX1 mutation (L381H) was discovered in the asymptomatic 8-month-old brother of a boy with primary adrenal failure. The infant had impaired adrenal…”
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Role of Ets2 in cyclic AMP regulation of the human chorionic gonadotropin β promoter by Johnson, Wade, Jameson, J.Larry

“…Activation of the human chorionic gonadotropin β (hCGβ) by the protein kinase A (PKA) pathway has been shown to occur through an activating protein-2…”
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Molecular mechanisms of end-organ resistance by Jameson, J.Larry

“…Hormone resistance is caused by mutations in hormone receptors or by functional desensitization of hormone signaling pathways. Mutations that cause hormone…”
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Ras oncogene mutations in benign and malignant thyroid neoplasms by Karga, H, Lee, J K, Vickery, Jr, A L, Thor, A, Gaz, R D, Jameson, J L

“…Current models for tumorigenesis propose that a series of genetic alterations occur during the progression from the normal cell to the malignant phenotype…”
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Molecular and Structural Analysis of Two Novel STAR Mutations in Patients with Lipoid Congenital Adrenal Hyperplasia by Achermann, John C., Meeks, Joshua J., Jeffs, Baxter, Das, Urmi, Clayton, Peter E., Brook, Charles G.D., Jameson, J.Larry

“…Mutations in the gene encoding steroidogenic acute regulatory protein (StAR) cause lipoid congenital adrenal hyperplasia. We report a novel homozygous splice…”
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The Role of DAX-1 in Reproduction by Yu, Richard N, Achermann, John C, Ito, Masafumi, Jameson, J.Larry

“…Mutations in a gene referred to as Dax-1 cause an X-linked form of adrenal hypoplasia congenita (AHC). The disorder is limited to males and is characterized by…”
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Combined Pituitary Hormone Deficiency in an Inbred Brazilian Kindred Associated with a Mutation in the PROP-1 Gene by Nogueira, Celia R., Sabacan, Leah, Jameson, J.Larry, Medeiros-Neto, Geraldo, Kopp, Peter

“…Mutations in the pituitary-specificpaired-like homeodomain transcription factor PROP-1 result in combined pituitary hormone deficiency (CPHD) which includes…”
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A Novel Mutation (M310L) in the Thyroid Hormone Receptor β Causing Resistance to Thyroid Hormone in a Brazilian Kindred and a Neonate by Furlanetto, Tania Weber, Kopp, Peter, Peccin, Simone, Gu, Wen-Xia, Jameson, J.Larry

“…Resistance to thyroid hormone (RTH) is an inherited syndrome of reduced tissue responsiveness to thyroid hormone (T3) caused by mutations in the thyroid…”
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A Novel Aminoterminal Mutation in the KAL-1 Gene in a Large Pedigree with X-Linked Kallmann Syndrome by Gu, Wen-Xia, Colquhoun-Kerr, James S., Kopp, Peter, Bode, Hans H., Jameson, J.Larry

“…Kallmann syndrome is characterized by hypogonadotropic hypogonadism and anosmia. Autosomal dominant, autosomal recessive, and X-linked patterns of transmission…”
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Clonal X-inactivation analysis of human tumours using the human androgen receptor gene (HUMARA) polymorphism: a non-radioactive and semiquantitative strategy applicable to fresh and archival tissue by Kopp, Peter, Jaggi, Rolf, Tobler, Andreas, Borisch, Bettina, Oestreicher, Madeleine, Sabacan, Leah, Jameson, J.Larry, Fey, Martin F.

“…Assessment of clonality of cellular proliferations is important in experimental and clinical cancer research. X-chromosome inactivation studies are widely used…”
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Development of a bioassay for FSH using a recombinant human FSH receptor and a cAMP responsive luciferase reporter gene by Albanese, C, Christin-Maitre, S, Sluss, P M, Crowley, W F, Jameson, J L

“…FSH exerts its actions primarily by increasing cAMP levels via a G protein-linked transmembrane receptor. We report the development of a bioassay for FSH using…”
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Multiple promoter elements in the human chorionic gonadotropin beta subunit genes distinguish their expression from the luteinizing hormone beta gene by Hollenberg, A N, Pestell, R G, Albanese, C, Boers, M E, Jameson, J L

“…The beta subunit of human chorionic gonadotropin (CG beta) is encoded by a cluster of six genes, which have developed through gene duplication from an…”
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Negative regulation of the glycoprotein hormone alpha gene promoter by thyroid hormone: mutagenesis of a proximal receptor binding site preserves transcriptional repression by Madison, L D, Ahlquist, J A, Rogers, S D, Jameson, J L

“…Transcription of the glycoprotein hormone alpha gene is repressed by the thyroid hormone receptor (TR) in a hormone dependent manner. Previous studies…”
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