Search Results - "James W. Dear"

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review by Ranasinghe, Priyanga, Addison, Melisande L., Dear, James W., Webb, David J.

“…Abstract Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology,…”
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Zebrafish as model organisms for studying drug‐induced liver injury by Vliegenthart, A. D. Bastiaan, Tucker, Carl S., Del Pozo, Jorge, Dear, James W.

“…Drug‐induced liver injury (DILI) is a major challenge in clinical medicine and drug development. New models are needed for predicting which potential…”
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Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital by Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

“…Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would…”
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Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes by Sabbisetti, Venkata S, Waikar, Sushrut S, Antoine, Daniel J, Smiles, Adam, Wang, Chang, Ravisankar, Abinaya, Ito, Kazumi, Sharma, Sahil, Ramadesikan, Swetha, Lee, Michelle, Briskin, Rebeccah, De Jager, Philip L, Ngo, Thanh Thu, Radlinski, Mark, Dear, James W, Park, Kevin B, Betensky, Rebecca, Krolewski, Andrzej S, Bonventre, Joseph V

“…Currently, no blood biomarker that specifically indicates injury to the proximal tubule of the kidney has been identified. Kidney injury molecule-1 (KIM-1) is…”
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Identification and proteomic profiling of exosomes in human cerebrospinal fluid by Street, Jonathan M, Barran, Perdita E, Mackay, C Logan, Weidt, Stefan, Balmforth, Craig, Walsh, Tim S, Chalmers, Rod T A, Webb, David J, Dear, James W

“…Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery…”
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Quantification of human urinary exosomes by nanoparticle tracking analysis by Oosthuyzen, Wilna, Sime, Nicole E. L., Ivy, Jessica R., Turtle, Emma J., Street, Jonathan M., Pound, John, Bath, Louise E., Webb, David J., Gregory, Christopher D., Bailey, Matthew A., Dear, James W.

“…Key points •  Exosomes are vesicles that are released from the kidney into the urine. They contain RNA and protein from the cell of origin and can track…”
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Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial by Bateman, D Nicholas, Prof, Dear, James W, PhD, Thanacoody, H K Ruben, MD, Thomas, Simon H L, MD, Eddleston, Michael, PhD, Sandilands, Euan A, MB, Coyle, Judy, BSc, Cooper, Jamie G, MB, Rodriguez, Aryelly, MSc, Butcher, Isabella, PhD, Lewis, Steff C, PhD, Vliegenthart, A D Bastiaan, BSc, Veiraiah, Aravindan, MB, Webb, David J, Prof, Gray, Alasdair, MD

“…Summary Background Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated…”
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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury by Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A

“…Acetaminophen ( -acetyl- -aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11…”
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Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity by Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus

“…In addition to hepatocytes, the liver comprises a host of specialised non-parenchymal cells which are important to consider in the development of in vitro…”
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Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury by Rissin, David M, López-Longarela, Barbara, Pernagallo, Salvatore, Ilyine, Hugh, Vliegenthart, A D Bastiaan, Dear, James W, Díaz-Mochón, Juan J, Duffy, David C

“…We have developed a single probe method for detecting microRNA from human serum using single molecule arrays, with sequence specificity down to a single base,…”
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Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells by Street, Jonathan M., Birkhoff, Willem, Menzies, Robert I., Webb, David J., Bailey, Matthew A., Dear, James W.

“…Non‐technical summary  Like most cells, those of the kidney release protein and RNA in structures called exosomes. It is possible that the contents of exosomes…”
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Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis by Armstrong, Susan K., Hunter, Robert W., Oosthyuzen, Wilna, Parys, Maciej, Gow, Adam G., Schmitz, Silke Salavati, Dear, James W., Mellanby, Richard J.

“…Background Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive and specific for a…”
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Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon? by Clarke, Joanna I, Dear, James W, Antoine, Daniel J

“…Drug-induced liver injury (DILI) represents a serious medical challenge and a potentially fatal adverse event. Currently, DILI is a diagnosis of exclusion, and…”
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Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter by Ivy, Jessica R, Oosthuyzen, Wilna, Peltz, Theresa S, Howarth, Amelia R, Hunter, Robert W, Dhaun, Neeraj, Al-Dujaili, Emad A.S, Webb, David J, Dear, James W, Flatman, Peter W, Bailey, Matthew A

“…Blood pressure (BP) normally dips during sleep, and nondipping increases cardiovascular risk. Hydrochlorothiazide restores the dipping BP profile in nondipping…”
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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment by Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj

“…In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response,…”
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miR-122 direct detection in human serum by time-gated fluorescence imaging by Garcia-Fernandez, Emilio, Gonzalez-Garcia, M Carmen, Pernagallo, Salvatore, Ruedas-Rama, Maria J, Fara, Mario A, López-Delgado, Francisco J, Dear, James W, Ilyine, Hugh, Ress, Cristina, Díaz-Mochón, Juan J, Orte, Angel

“…A simple method for direct detection of microRNAs (miRs) in human serum without the use of polymerase amplification is presented, achieving low miR-122…”
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Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells by Oosthuyzen, Wilna, Scullion, Kathleen M, Ivy, Jessica R, Morrison, Emma E, Hunter, Robert W, Starkey Lewis, Philip J, O'Duibhir, Eoghan, Street, Jonathan M, Caporali, Andrea, Gregory, Christopher D, Forbes, Stuart J, Webb, David J, Bailey, Matthew A, Dear, James W

“…Extracellular vesicles (ECVs) facilitate intercellular communication along the nephron, with the potential to change the function of the recipient cell…”
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Activated neutrophil fluorescent imaging technique for human lungs by Craven, Thomas H., Walton, Tashfeen, Akram, Ahsan R., Scholefield, Emma, McDonald, Neil, Marshall, Adam D.L., Humphries, Duncan C., Mills, Bethany, Campbell, Thane A., Bruce, Annya, Mair, Joanne, Dear, James W., Newby, David E., Hill, Adam T., Walsh, Timothy S., Haslett, Chris, Dhaliwal, Kevin

“…Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in…”
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Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury by Yasuda, Hideo, Leelahavanichkul, Asada, Tsunoda, Shinichiro, Dear, James W, Takahashi, Yoshiyuki, Ito, Shuichi, Hu, Xuzhen, Zhou, Hua, Doi, Kent, Childs, Richard, Klinman, Dennis M, Yuen, Peter S T, Star, Robert A

“…Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies. Toll-like receptors (TLRs) sense bacterial products and…”
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Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis by Dear, James W., Antoine, Daniel J., Starkey‐Lewis, Philip, Goldring, Christopher E., Park, B. Kevin

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