Search Results - "James M. Murphy"

The Structural Basis of Necroptotic Cell Death Signaling by Petrie, Emma J., Czabotar, Peter E., Murphy, James M.

“…The recent implication of the cell death pathway, necroptosis, in innate immunity and a range of human pathologies has led to intense interest in the…”
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The molecular regulation of Janus kinase (JAK) activation by Babon, Jeffrey J, Lucet, Isabelle S, Murphy, James M, Nicola, Nicos A, Varghese, Leila N

“…The JAK (Janus kinase) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1,…”
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The molecular basis of JAK/STAT inhibition by SOCS1 by Liau, Nicholas P. D., Laktyushin, Artem, Lucet, Isabelle S., Murphy, James M., Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.

“…The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as…”
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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
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MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death by Jaco, Isabel, Annibaldi, Alessandro, Lalaoui, Najoua, Wilson, Rebecca, Tenev, Tencho, Laurien, Lucie, Kim, Chun, Jamal, Kunzah, Wicky John, Sidonie, Liccardi, Gianmaria, Chau, Diep, Murphy, James M., Brumatti, Gabriela, Feltham, Rebecca, Pasparakis, Manolis, Silke, John, Meier, Pascal

“…TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes…”
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner by Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M., Vince, James E.

“…Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase…”
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis by Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.

“…Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is…”
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Targeting focal adhesion kinase in cancer cells and the tumor microenvironment by Murphy, James M., Rodriguez, Yelitza A. R., Jeong, Kyuho, Ahn, Eun-Young Erin, Lim, Ssang-Taek Steve

“…Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is frequently overexpressed in advanced human cancers. Recent studies have…”
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Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity by Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.

“…Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (suppressor of cytokine signaling-3) is a major…”
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Bio-Zombie: the rise of pseudoenzymes in biology by Murphy, James M, Farhan, Hesso, Eyers, Patrick A

“…Pseudoenzymes are catalytically dead counterparts of enzymes. Despite their first description some 50 years ago, the importance and functional diversity of…”
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Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase by Murphy, James M., Nakatani, Yoshio, Jamieson, Sam A., Dai, Weiwen, Lucet, Isabelle S., Mace, Peter D.

“…CCAAT-enhancer binding proteins (C/EBPs) are transcription factors that play a central role in the differentiation of myeloid cells and adipocytes. Tribbles…”
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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death by Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C.J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John

“…Significance The four-helix bundle (4HB) domain of Mixed Lineage Kinase Domain-Like (MLKL) bears two clusters of residues that are required for cell death by…”
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FAK Family Kinases in Vascular Diseases by Murphy, James M, Jeong, Kyuho, Lim, Ssang-Taek Steve

“…In various vascular diseases, extracellular matrix (ECM) and integrin expression are frequently altered, leading to focal adhesion kinase (FAK) or proline-rich…”
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Activated MLKL attenuates autophagy following its translocation to intracellular membranes by Frank, Daniel, Vaux, David L., Murphy, James M., Vince, James E., Lindqvist, Lisa M.

“…Necroptosis is an inflammatory form of programmed cell death mediated by the pseudokinase mixed-lineage kinase domain-like protein (MLKL). Upon phosphorylation…”
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The Epigenetic Regulator SMCHD1 in Development and Disease by Jansz, Natasha, Chen, Kelan, Murphy, James M, Blewitt, Marnie E

“…It has very recently become clear that the epigenetic modifier SMCHD1 has a role in two distinct disorders: facioscapulohumoral muscular dystrophy (FSHD) and…”
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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis by Rickard, James A., O’Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby J., Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti, Silke, John

“…Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and…”
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The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) by Murphy, James M.

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Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis by Liu, Zikou, Dagley, Laura F, Shield‐Artin, Kristy, Young, Samuel N, Bankovacki, Aleksandra, Wang, Xiangyi, Tang, Michelle, Howitt, Jason, Stafford, Che A, Nachbur, Ueli, Fitzgibbon, Cheree, Garnish, Sarah E, Webb, Andrew I, Komander, David, Murphy, James M, Hildebrand, Joanne M, Silke, John

“…Mixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting…”
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Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway by Chatfield, Simon M, Grebe, Kathrin, Whitehead, Lachlan W, Rogers, Kelly L, Nebl, Thomas, Murphy, James M, Wicks, Ian P

“…Neutrophil extracellular traps (NETs) and the cell death associated with it (NETosis) have been implicated in numerous diseases. Mechanistic studies of NETosis…”
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The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation by Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.

“…Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases…”
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