Search Results - "James G. Conway"

Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580 by James G. Conway, McDonald, Brad, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Jansen, Marilyn, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, James, Ian, Karen Fuller, Timothy J. Chambers, Kull, Frederick C., Stanley D. Chamberlain, Hutchins, Jeff T., Schlessinger, Joseph

“…Colony-stimulating-factoM (CSF-1) signaling through cFMS receptor kinase is increased in several diseases. To help investigate the role of cFMS kinase in…”
Get full text

Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats by Conway, James G, Pink, Heather, Bergquist, Mandy L, Han, Bajin, Depee, Scott, Tadepalli, Sarva, Lin, Peiyuan, Crumrine, R Christian, Binz, Jane, Clark, Richard L, Selph, Jeffrey L, Stimpson, Stephen A, Hutchins, Jeff T, Chamberlain, Stanley D, Brodie, Thomas A

“…The cFMS (cellular homolog of the V-FMS oncogene product of the Susan McDonough strain of feline sarcoma virus) (Proc Natl Acad Sci U S A 83:3331-3335, 1986)…”
Get more information

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs by Yang, Shyh-Ming, Tang, Yuting, Rano, Thomas, Lu, Huajun, Kuo, Gee-Hong, Gaul, Michael D, Li, Yaxin, Ho, George, Lang, Wensheng, Conway, James G, Liang, Yin, Lenhard, James M, Demarest, Keith T, Murray, William V

“…Design, synthesis, and biological evaluation of pyridazine-based, 4-bicyclic heteroaryl-piperidine derivatives as potent stearoyl-CoA desaturase-1 (SCD1)…”
Get full text

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs by Yang, Shyh-Ming, Tang, Yuting, Zhang, Rui, Lu, Huajun, Kuo, Gee-Hong, Gaul, Michael D., Li, Yaxin, Ho, George, Conway, James G., Liang, Yin, Lenhard, James M., Demarest, Keith T., Murray, William V.

“…A new series of urea-based, 4-bicyclic heteroaryl-piperidine derivatives as potent SCD1 inhibitors is described. The structure–activity relationships focused…”
Get full text

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor by McGeehan, Gerard M, Becherer, J. David, Bast, Robert C, Boyer, Cinda M, Champion, Brian, Connolly, Kevin M, Conway, James G, Furdon, Paul, Karp, Stephen, Kidao, Sudha, McElroy, Andrew B, Nichols, James, Pryzwansky, Katherine M, Schoenen, Frank, Sekut, Les, Truesdale, Anne, Verghese, Margrith, Warner, Janet, Ways, Judy P

“…Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages. TNF-alpha is synthesized…”
Get full text

Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE) by Rabinowitz, Michael H, Andrews, Robert C, Becherer, J. David, Bickett, D. Mark, Bubacz, Dulce G, Conway, James G, Cowan, David J, Gaul, Micheal, Glennon, Kimberly, Lambert, Millard H, Leesnitzer, M. Anthony, McDougald, Darryl L, Moss, Marcia L, Musso, David L, Rizzolio, Michele C

“…A program to improve upon the in vitro, in vivo, and physicochemical properties of N-hydroxyformamide TACE inhibitor GW 3333 (1) is described. Using the…”
Get full text

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators Di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats by MARSMAN, D. S, CATTLEY, R. C, CONWAY, J. G, POPP, J. A

“…The mechanism of hepatocarcinogenesis caused by peroxisome proliferators (PP) is poorly understood, making it difficult to predict the carcinogenicity of PP to…”
Get full text

Regulation of TNF-α secretion by a specific melanocortin-1 receptor peptide agonist by Ignar, Diane M., Andrews, John L., Jansen, Marilyn, Eilert, Michelle M., Pink, Heather M., Lin, Peiyuan, Sherrill, Ronald G., Szewczyk, Jerzy R., Conway, James G.

“…The lack of specific pharmacological tools has impeded the evaluation of the role of each melanocortin receptor (MCR) subtype in the myriad physiological…”
Get full text

The Effects of the Symbiont Rickettsia on the Interactions between a Whitefly Pest (Bemisia tabaci) and a General Fungal Pathogen (Beauveria bassiana) by Conway, James G

“…Some intracellular symbionts of insects confer host protection from a variety of bacterial, fungal and viral pathogens as well as from predators and…”
Get full text

Microcirculation of hepatic nodules from diethylnitrosamine-treated rats by CONWAY, J. G, POPP, J. A, THURMAN, R. G

“…The microcirculation of nodules (0.5 to 10 mm in diameter) from diethylnitrosamine-treated rats was studied in perfused livers. Microlight guides were placed…”
Get full text

Role of fatty acyl coenzyme A oxidase in the efflux of oxidized glutathione from perfused livers of rats treated with the peroxisome proliferator nafenopin by Conway, J G, Neptun, D A, Garvey, L K, Popp, J A

“…The diffusion of H2O2 into the cytoplasm from peroxisomes during high rates of peroxisomal beta oxidation of fatty acids was studied in perfused livers from…”
Get full text

Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats by Conway, J G, Popp, J A, Ji, S, Thurman, R G

“…The portal circulation of diethylnitrosamine-initiated nodules (0.5 to 7 mm in diameter) was studied in rat livers perfused exclusively via the portal vein…”
Get full text

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases by Conway, J G, Andrews, R C, Beaudet, B, Bickett, D M, Boncek, V, Brodie, T A, Clark, R L, Crumrine, R C, Leenitzer, M A, McDougald, D L, Han, B, Hedeen, K, Lin, P, Milla, M, Moss, M, Pink, H, Rabinowitz, M H, Tippin, T, Scates, P W, Selph, J, Stimpson, S A, Warner, J, Becherer, J D

“…Tumor necrosis factor-alpha (TNF)-converting enzyme (TACE) cleaves the precursor form of TNF, allowing the mature form to be secreted into the extracellular…”
Get more information

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor by Conway, J G, Wakefield, J A, Brown, R H, Marron, B E, Sekut, L, Stimpson, S A, McElroy, A, Menius, J A, Jeffreys, J J, Clark, R L

“…Considerable evidence has associated the expression of matrix metalloproteinases (MMPs) with the degradation of cartilage and bone in chronic conditions such…”
Get full text

N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution by Musso, David L., Andersen, Marc W., Andrews, Robert C., Austin, Richard, Beaudet, Elizabeth J., Becherer, J.David, Bubacz, Dulce G., Bickett, D.Mark, Chan, Joseph H., Conway, James G., Cowan, David J., Gaul, Michael D., Glennon, Kimberly C., Hedeen, Kevin M., Lambert, Millard H., Leesnitzer, M.Anthony, McDougald, Darryl L., Mitchell, Justin L., Moss, Marcia L., Rabinowitz, Michael H., Rizzolio, Michele C., Schaller, Lee T., Stanford, Jennifer B., Tippin, Timothy K., Warner, Janet R., Whitesell, L.Graham, Wiethe, Robert W.

“…N-Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and…”
Get full text

Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643 by Conway, J G, Tomaszewski, K E, Olson, M J, Cattley, R C, Marsman, D S, Popp, J A

“…Quantitative comparisons of the time course of biochemical and morphological changes induced by peroxisome proliferators resulting in low and high incidences…”
Get more information

Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis by Conway, J G, Trexler, S J, Wakefield, J A, Marron, B E, Emerson, D L, Bickett, D M, Deaton, D N, Garrison, D, Elder, M, McElroy, A, Willmott, N, Dockerty, A J, McGeehan, G M

“…Four potent, synthetic inhibitors of matrix metalloproteinases (MMPs) were assessed as inhibitors of tumor growth and spontaneous metastasis to the lung. Mat…”
Get full text

Effect of the Hepatocarcinogenic Peroxisome Proliferator Wy-14,643 in Vivo: No Increase in Ethane Exhalation or Hepatic Conjugated Dienes by Conway, J.G., Popp, J.A.

“…Exhalation of ethane and pentane was used to access lipid peroxidation in rats receiving the hepatocarcinogenic peroxisome proliferator Wy-14,643 at 0.1% in…”
Get full text

Regulation of tumour necrosis factor- alpha processing by a metallproteinase inhibitor by McGeehan, Gerard M, Becherer, JDavid, Bast, Robert C, Boyer, Cinda M, Champion, Brian, Connolly, Kevin M, Conway, James G, Furdon, Paul, Karp, Stephen, Kidao, Sudha, McElroy, Andrew B, Nichols, James, Pryzwansky, Katherine M, Schoenen, Frank, Sekut, Les, Truesdale, Anne

“…Tumour necrosis factor- alpha (TNF- alpha ) is potent pro-inflammatory agent produced primarily by activated monocytes and macrophages. TNF- alpha is…”
Get full text

Carcinogen treatment increases glutathione hydrolysis by gamma-glutamyl transpeptidase by Conway, J G, Neptun, D A, Garvey, L K, Popp, J A

“…The effect of carcinogen treatment on gamma-glutamyl transpeptidase (GGT)-mediated hydrolysis of GSH to glutamate and cysteinylglycine in the blood and bile…”
Get more information