Search Results - "James Fitzpatrick"

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet by Hatori, Megumi, Vollmers, Christopher, Zarrinpar, Amir, DiTacchio, Luciano, Bushong, Eric A., Gill, Shubhroz, Leblanc, Mathias, Chaix, Amandine, Joens, Matthew, Fitzpatrick, James A.J., Ellisman, Mark H., Panda, Satchidananda

“…While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat…”
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Cryo-EM structures of the ATP release channel pannexin 1 by Deng, Zengqin, He, Zhihui, Maksaev, Grigory, Bitter, Ryan M., Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng

“…The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1) has been implicated in many physiological and pathophysiological processes…”
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Neural mechanisms for evaluating environmental variability in Caenorhabditis elegans by Calhoun, Adam J., Tong, Ada, Pokala, Navin, Fitzpatrick, James A.J., Sharpee, Tatyana O., Chalasani, Sreekanth H.

“…The ability to evaluate variability in the environment is vital for making optimal behavioral decisions. Here we show that Caenorhabditis elegans evaluates…”
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Liver‐Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer by Newberry, Elizabeth P., Hall, Zoe, Xie, Yan, Molitor, Elizabeth A., Bayguinov, Peter O., Strout, Gregory W., Fitzpatrick, James A.J., Brunt, Elizabeth M., Griffin, Julian L., Davidson, Nicholas O.

“…Background and Aims Human transmembrane 6 superfamily 2 (TM6SF2) variant rs58542926 is associated with NAFLD and HCC. However, conflicting reports in germline…”
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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders by Brioschi, Simone, Wang, Wei-Le, Peng, Vincent, Wang, Meng, Shchukina, Irina, Greenberg, Zev J, Bando, Jennifer K, Jaeger, Natalia, Czepielewski, Rafael S, Swain, Amanda, Mogilenko, Denis A, Beatty, Wandy L, Bayguinov, Peter, Fitzpatrick, James A J, Schuettpelz, Laura G, Fronick, Catrina C, Smirnov, Igor, Kipnis, Jonathan, Shapiro, Virginia S, Wu, Gregory F, Gilfillan, Susan, Cella, Marina, Artyomov, Maxim N, Kleinstein, Steven H, Colonna, Marco

“…The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the…”
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Gating of human TRPV3 in a lipid bilayer by Deng, Zengqin, Maksaev, Grigory, Rau, Michael, Xie, Zili, Hu, Hongzhen, Fitzpatrick, James A. J., Yuan, Peng

“…The transient receptor potential cation channel subfamily V member 3 (TRPV3) channel plays a critical role in skin physiology, and mutations in TRPV3 result in…”
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Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses by Kim, Kyunghee X, Payne, Shelby, Yang-Hood, Aizhen, Li, Song-Zhe, Davis, Bethany, Carlquist, Jason, V-Ghaffari, Babak, Gantz, Jay A, Kallogjeri, Dorina, Fitzpatrick, James A J, Ohlemiller, Kevin K, Hirose, Keiko, Rutherford, Mark A

“…Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse…”
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Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance by Deng, Zengqin, Maksaev, Grigory, Schlegel, Angela M., Zhang, Jingying, Rau, Michael, Fitzpatrick, James A. J., Haswell, Elizabeth S., Yuan, Peng

“…Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including…”
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Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel by Mount, Jonathan, Maksaev, Grigory, Summers, Brock T., Fitzpatrick, James A. J., Yuan, Peng

“…Mechanosensitive channels of small conductance, found in many living organisms, open under elevated membrane tension and thus play crucial roles in biological…”
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Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation by Petroff, John T., Dietzen, Noah M., Santiago-McRae, Ezry, Deng, Brett, Washington, Maya S., Chen, Lawrence J., Trent Moreland, K., Deng, Zengqin, Rau, Michael, Fitzpatrick, James A. J., Yuan, Peng, Joseph, Thomas T., Hénin, Jérôme, Brannigan, Grace, Cheng, Wayland W. L.

“…Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid…”
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Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila by Hervas, Ruben, Rau, Michael J, Park, Younshim, Zhang, Wenjuan, Murzin, Alexey G, Fitzpatrick, James A J, Scheres, Sjors H W, Si, Kausik

“…How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation…”
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Cryo-EM structure of the prothrombin-prothrombinase complex by Ruben, Eliza A., Summers, Brock, Rau, Michael J., Fitzpatrick, James A.J., Di Cera, Enrico

“…The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa…”
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Cryo-EM structures of human coagulation factors V and Va by Ruben, Eliza A., Rau, Michael J., Fitzpatrick, James A.J., Di Cera, Enrico

“…Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates…”
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A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest by Hayashi, Makoto T, Cesare, Anthony J, Fitzpatrick, James A J, Lazzerini-Denchi, Eros, Karlseder, Jan

“…Mammalian telomeres are protected by shelterin components to avoid being recognized as DNA damage. Now cells under prolonged mitotic arrest are found to…”
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Characterization of the bone marrow adipocyte niche with three-dimensional electron microscopy by Robles, Hero, Park, SungJae, Joens, Matthew S., Fitzpatrick, James A.J., Craft, Clarissa S., Scheller, Erica L.

“…Unlike white and brown adipose tissues, the bone marrow adipocyte (BMA) exists in a microenvironment containing unique populations of hematopoietic and…”
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Structural and functional analysis of human pannexin 2 channel by He, Zhihui, Zhao, Yonghui, Rau, Michael J., Fitzpatrick, James A. J., Sah, Rajan, Hu, Hongzhen, Yuan, Peng

“…The pannexin 2 channel (PANX2) participates in multiple physiological processes including skin homeostasis, neuronal development, and ischemia-induced brain…”
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Donor Macrophages Modulate Rejection After Heart Transplantation by Kopecky, Benjamin J., Dun, Hao, Amrute, Junedh M., Lin, Chieh-Yu, Bredemeyer, Andrea L., Terada, Yuriko, Bayguinov, Peter O., Koenig, Andrew L., Frye, Christian C., Fitzpatrick, James A.J., Kreisel, Daniel, Lavine, Kory J.

“…Cellular rejection after heart transplantation imparts significant morbidity and mortality. Current immunosuppressive strategies are imperfect, target…”
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Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract by Walker, Jennifer N., Flores-Mireles, Ana L., Pinkner, Chloe L., Schreiber, Henry L., Joens, Matthew S., Park, Alyssa M., Potretzke, Aaron M., Bauman, Tyler M., Pinkner, Jerome S., Fitzpatrick, James A. J., Desai, Alana, Caparon, Michael G., Hultgren, Scott J.

“…Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to…”
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Resident cardiac macrophages mediate adaptive myocardial remodeling by Wong, Nicole R., Mohan, Jay, Kopecky, Benjamin J., Guo, Shuchi, Du, Lixia, Leid, Jamison, Feng, Guoshuai, Lokshina, Inessa, Dmytrenko, Oleksandr, Luehmann, Hannah, Bajpai, Geetika, Ewald, Laura, Bell, Lauren, Patel, Nikhil, Bredemeyer, Andrea, Weinheimer, Carla J., Nigro, Jessica M., Kovacs, Attila, Morimoto, Sachio, Bayguinov, Peter O., Fisher, Max.R., Stump, W. Tom, Greenberg, Michael, Fitzpatrick, James A.J., Epelman, Slava, Kreisel, Daniel, Sah, Rajan, Liu, Yongjian, Hu, Hongzhen, Lavine, Kory J.

“…Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine…”
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Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes by Deveryshetty, Jaigeeth, Chadda, Rahul, Mattice, Jenna R., Karunakaran, Simrithaa, Rau, Michael J., Basore, Katherine, Pokhrel, Nilisha, Englander, Noah, Fitzpatrick, James A. J., Bothner, Brian, Antony, Edwin

“…Homologous recombination (HR) is an essential double-stranded DNA break repair pathway. In HR, Rad52 facilitates the formation of Rad51 nucleoprotein filaments…”
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