Search Results - "James, Wesley A"

Group B streptococcus serotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distribution by Ippolito, Danielle L, James, Wesley A, Tinnemore, Deborah, Huang, Raywin R, Dehart, Mary J, Williams, Julie, Wingerd, Mark A, Demons, Samandra T

“…Group B Streptococcus (GBS) serotype (Ia, Ib, II-IX) correlates with pathogen virulence and clinical prognosis. Epidemiological studies of seroprevalence are…”
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Solubility measurement of polymorphic compounds via the pH-metric titration technique by Fioritto, Ann F., Bhattachar, Shobha N., Wesley, James A.

“…In drug development, the thermodynamically most stable form of a compound is preferred because metastable forms are prone to transform to the stable form…”
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Solubility: it's not just for physical chemists by Bhattachar, Shobha N., Deschenes, Laura A., Wesley, James A.

“…Solubility data are used to make crucial decisions from the earliest stages of drug discovery throughout the development process, but often the decision-maker…”
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Assessment of In Vivo Clinical Product Performance of a Weak Basic Drug by Integration of In Vitro Dissolution Tests and Physiologically Based Absorption Modeling by Ding, Xuan, Gueorguieva, Ivelina, Wesley, James A., Burns, Lee J., Coutant, Carrie A.

“…Effective integration of in vitro tests and absorption modeling can greatly improve our capability in understanding, comparing, and predicting in vivo…”
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Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery by Bhattachar, Shobha N., Wesley, James A., Seadeek, Christopher

“…Solubility measurements using chemiluminescent nitrogen detection (CLND) has advantages of reduced compound requirement and increased throughput compared to…”
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Dissolution behavior of a poorly water soluble compound in the presence of Tween 80 by CHEN, Linna R, WESLEY, James A, BHATTACHAR, Shobha, RUIZ, Bienvenido, BAHASH, Korey, BABU, Suresh R

“…To investigate the mechanism by which Tween 80 impedes the dissolution of CI-1041, a poorly water-soluble compound in its free form. Bulk powder and intrinsic…”
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Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus by Bhattachar, Shobha N, Wesley, James A, Fioritto, Ann, Martin, Peter J, Babu, Suresh R

“…Dissolution of Pfizer Compound PD198306, a poorly soluble compound, was studied in 25 mM pH 9 sodium phosphate solution with 0.5% SLS using the flow-through…”
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Increased Dissolution Rate and Bioavailability Through Comicronization with Microcrystalline Cellulose by Spence, Julie K., Bhattachar, Shobha N., Wesley, James A., Martin, Peter J., Babu, Suresh R.

“…Micronization is a commonly used enabling technology to improve the bioavailability of compounds where absorption is dissolution rate limited. However,…”
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Group B streptococcusserotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distribution by Ippolito, Danielle L, James, Wesley A, Tinnemore, Deborah, Huang, Raywin R, Dehart, Mary J, Williams, Julie, Wingerd, Mark A, Demons, Samandra T

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It started with the cow path: working flatter, not faster by Wesley, J A

“…Our first impulse was to pave the cow path, to computerize the way manual procedures were done. Then we tried to straighten out the cow path, to make those…”
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From benefit evaporation to value actualization by Wesley, J A

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