Search Results - "James, Tojo"

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship by Marabita, Francesco, Almgren, Malin, Sjöholm, Louise K., Kular, Lara, Liu, Yun, James, Tojo, Kiss, Nimrod B., Feinberg, Andrew P., Olsson, Tomas, Kockum, Ingrid, Alfredsson, Lars, Ekström, Tomas J., Jagodic, Maja

“…Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a…”
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Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms by Lindén, Magdalena, Ramírez Sepúlveda, Jorge I, James, Tojo, Thorlacius, Gudny Ella, Brauner, Susanna, Gómez-Cabrero, David, Olsson, Tomas, Kockum, Ingrid, Wahren-Herlenius, Marie

“…Systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are autoimmune disorders characterized by autoantibodies, dysregulated B cells, and…”
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Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis by Bergman, Petra, Piket, Eliane, Khademi, Mohsen, James, Tojo, Brundin, Lou, Olsson, Tomas, Piehl, Fredrik, Jagodic, Maja

“…OBJECTIVE:To explore circulating microRNAs (miRNAs) in cell-free CSF as novel biomarkers for multiple sclerosis (MS). METHODS:Profiling of miRNAs in CSF of…”
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Author Correction: Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship by Marabita, Francesco, Almgren, Malin, Sjöholm, Louise K., Kular, Lara, Liu, Yun, James, Tojo, Kiss, Nimrod B., Feinberg, Andrew P., Olsson, Tomas, Kockum, Ingrid, Alfredsson, Lars, Ekström, Tomas J., Jagodic, Maja

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine by Struyf, Nona, Österroos, Albin, Vesterlund, Mattias, Arnroth, Cornelia, James, Tojo, Sunandar, Stephanie, Mermelekas, Georgios, Bohlin, Anna, Hamberg Levedahl, Kerstin, Bengtzén, Sofia, Jafari, Rozbeh, Orre, Lukas M., Lehtiö, Janne, Lehmann, Sören, Östling, Päivi, Kallioniemi, Olli, Seashore-Ludlow, Brinton, Erkers, Tom

“…Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229…”
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DNA methylation as a mediator of HLA-DRB1 15:01 and a protective variant in multiple sclerosis by Kular, Lara, Liu, Yun, Ruhrmann, Sabrina, Zheleznyakova, Galina, Marabita, Francesco, Gomez-Cabrero, David, James, Tojo, Ewing, Ewoud, Lindén, Magdalena, Górnikiewicz, Bartosz, Aeinehband, Shahin, Stridh, Pernilla, Link, Jenny, Andlauer, Till F.M, Gasperi, Christiane, Wiendl, Heinz, Zipp, Frauke, Gold, Ralf, Tackenberg, Björn, Weber, Frank, Hemmer, Bernhard, Strauch, Konstantin, Heilmann-Heimbach, Stefanie, Rawal, Rajesh, Schminke, Ulf, Schmidt, Carsten O, Kacprowski, Tim, Franke, Andre, Laudes, Matthias, Dilthey, Alexander T, Celius, Elisabeth Gulowsen, Søndergaard, Helle Bach, Tegnér, Jesper, Harbo, Hanne Flinstad, Oturai, Annette B, Olafsson, Sigurgeir, Eggertsson, Hannes P, Halldorsson, Bjarni V, Hjaltason, Haukur, Olafsson, Elias, Jonsdottir, Ingileif, Stefansson, Kari, Olsson, Tomas, Piehl, Fredrik, Ekström, Tomas J, Kockum, Ingrid, Feinberg, Andrew P, Jagodic, Maja

“…The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated…”
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Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients by James, Tojo, Lindén, Magdalena, Morikawa, Hiromasa, Fernandes, Sunjay Jude, Ruhrmann, Sabrina, Huss, Mikael, Brandi, Maya, Piehl, Fredrik, Jagodic, Maja, Tegnér, Jesper, Khademi, Mohsen, Olsson, Tomas, Gomez-Cabrero, David, Kockum, Ingrid

“…Abstract Despite advancements in genetic studies, it is difficult to understand and characterize the functional relevance of disease-associated genetic…”
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C-type lectin receptors Mcl and Mincle contro development of multiple sclerosis like neuroinflammation by N'diaye, M, Brauner, S, Flytzani, S, Kular, L, Warnecke, A, Adzemovic, MZ, Piket, E, Min, J-H, Edwards, W, Mela, F

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Data-Driven Molecular Hallmarks of Acute Myeloid Leukemia: Biological, Prognostic and Therapeutic Implications by Erkers, Tom, Marabita, Francesco, Struyf, Nona, Vesterlund, Mattias, James, Tojo, Arnroth, Cornelia, Bohlin, Anna, Bengtzén, Sofia, Österroos, Albin, Stahl, Matthias, Jafari, Rozbeh, Orre, Lukas, Pawitan, Yudi, Seashore-Ludlow, Brinton, Lehtiö, Janne, Lehmann, Sören, Östling, Päivi, Kallioniemi, Olli

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Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology by Zheleznyakova, Galina Yurevna, Piket, Eliane, Needhamsen, Maria, Hagemann-Jensen, Michael, Ekman, Diana, Han, Yanan, James, Tojo, Khademi, Mohsen, Nimer, Faiez Al, Scicluna, Patrick, Huang, Jesse, Kockum, Ingrid, Faridani, Omid R., Olsson, Tomas, Piehl, Fredrik, Jagodic, Maja

“…Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS). Small noncoding RNAs (sncRNAs) and, in…”
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A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis by Pahlevan Kakhki, Majid, Giordano, Antonino, Starvaggi Cucuzza, Chiara, Venkata S. Badam, Tejaswi, Samudyata, Samudyata, Lemée, Marianne Victoria, Stridh, Pernilla, Gkogka, Asimenia, Shchetynsky, Klementy, Harroud, Adil, Gyllenberg, Alexandra, Liu, Yun, Boddul, Sanjaykumar, James, Tojo, Sorosina, Melissa, Filippi, Massimo, Esposito, Federica, Wermeling, Fredrik, Gustafsson, Mika, Casaccia, Patrizia, Hillert, Jan, Olsson, Tomas, Kockum, Ingrid, Sellgren, Carl M., Golzio, Christelle, Kular, Lara, Jagodic, Maja

“…Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating…”
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Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome by Björk, Albin, Thorlacius, Gudny Ella, Mofors, Johannes, Richardsdotter Andersson, Elina, Ivanchenko, Margarita, Tingström, Joanna, James, Tojo, Brokstad, Karl A, Cox, Rebecca J, Jonsson, Roland, Kvarnström, Marika, Wahren-Herlenius, Marie

“…Abstract Objectives Infections have been suggested in the pathogenesis of primary SS (pSS). Systematic studies of immune responses to microbial antigens in…”
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C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation by N'diaye, Marie, Brauner, Susanna, Flytzani, Sevasti, Kular, Lara, Warnecke, Andreas, Adzemovic, Milena Z, Piket, Eliane, Min, Jin-Hong, Edwards, Will, Mela, Filia, Choi, Hoi Ying, Magg, Vera, James, Tojo, Linden, Magdalena, Reichardt, Holger M, Daws, Michael R, van Horssen, Jack, Kockum, Ingrid, Harris, Robert A, Olsson, Tomas, Guerreiro-Cacais, Andre O, Jagodic, Maja

“…Pattern recognition receptors (PRRs) are crucial for responses to infections and tissue damage; however, their role in autoimmunity is less clear. Herein we…”
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Genetic Landscape of Multiple Sclerosis Susceptibility by Leveraging Multi-Omics Data by James, Tojo

“…The main objective of the research studies presented in this thesis is to study the genetic variants and the expression of genes that relate to Multiple…”
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Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats by Bergman, Petra, James, Tojo, Kular, Lara, Ruhrmann, Sabrina, Kramarova, Tatiana, Kvist, Anders, Supic, Gordana, Gillett, Alan, Pivarcsi, Andor, Jagodic, Maja

“…MicroRNAs (miRNAs) are known to regulate most biological processes and have been found dysregulated in a variety of diseases, including multiple sclerosis…”
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High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia by Erkers, Tom, Seashore-Ludlow, Brinton, Struyf, Nona, Marabita, Francesco, James, Tojo, Malani, Disha, Vesterlund, Mattias, Stalhl, Matthias, Pawitan, Yudi, Lehmann, Sören, Östling, Päivi, Lehtiö, Janne, Kallioniemi, Olli

“…▪ Acute myeloid leukemia (AML) is the most common leukemia in adults and the prognosis is dismal. The heterogeneity of driver mutations in AML from one patient…”
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TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells by Parsa, Roham, Lund, Harald, Tosevski, Ivana, Zhang, Xing-Mei, Malipiero, Ursula, Beckervordersandforth, Jan, Merkler, Doron, Prinz, Marco, Gyllenberg, Alexandra, James, Tojo, Warnecke, Andreas, Hillert, Jan, Alfredsson, Lars, Kockum, Ingrid, Olsson, Tomas, Fontana, Adriano, Suter, Tobias, Harris, Robert A.

“…Intracerebral levels of Transforming Growth Factor beta (TGFβ) rise rapidly during the onset of experimental autoimmune encephalomyelitis (EAE), a mouse model…”
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Abstract 6612: Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia by Erkers, Tom, Struyf, Nona, James, Tojo, Marabita, Francesco, Vesterlund, Mattias, Vu, Nghia, Arnroth, Cornelia, Österroos, Albin, Bohlin, Anna, Bengtzén, Sofia, Stahl, Matthias, Jafari, Rozbeh, Orre, Lukas, Pawitan, Yudi, Seashore-Ludlow, Brinton, Lehtiö, Janne, Lehmann, Sören, Östling, Päivi, Kallioniemi, Olli

“…Abstract The cancer hallmark concept defines biological properties that play a key role in cancer development and progression. The hallmarks reflect generic…”
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Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship (vol 7, 14589, 2017) by Marabita, F, Almgren, M, Sjoholm, LK, Kular, L, Liu, Y, James, T, Kiss, NB, Feinberg, AP, Olsson, T, Kockum, I

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TGF[beta] regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells by Parsa, Roham, Lund, Harald, Tosevski, Ivana, Zhang, Xing-Mei, Malipiero, Ursula, Beckervordersandforth, Jan, Merkler, Doron, Prinz, Marco, Gyllenberg, Alexandra, James, Tojo, Warnecke, Andreas, Hillert, Jan, Alfredsson, Lars, Kockum, Ingrid, Olsson, Tomas, Fontana, Adriano, Suter, Tobias, Harris, Robert A

“…Intracerebral levels of Transforming Growth Factor beta (TGF[beta]) rise rapidly during the onset of experimental autoimmune encephalomyelitis (EAE), a mouse…”
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