Search Results - "James, R. Arden"

Tissue Manganese Concentrations in Young Male Rhesus Monkeys following Subchronic Manganese Sulfate Inhalation by Dorman, David C., Struve, Melanie F., Marshall, Marianne W., Parkinson, Carl U., James, R. Arden, Wong, Brian A.

“…High-dose human exposure to manganese results in manganese accumulation in the basal ganglia and dopaminergic neuropathology. Occupational manganese…”
Get full text

Maternal–fetal Distribution of Manganese in the Rat Following Inhalation Exposure to Manganese Sulfate by Dorman, David C., McElveen, Anna M., Marshall, Marianne W., Parkinson, Carl U., Arden James, R., Struve, Melanie F., Wong, Brian A.

“…Studies examining the pharmacokinetics of manganese during pregnancy have largely focused on the oral route of exposure and have shown that the amount of…”
Get full text

Olfactory Neuron Loss in Adult Male CD Rats Following Subchronic Inhalation Exposure to Hydrogen Sulfide by Brenneman, Karrie A., Arden James, R., Gross, Elizabeth A., Dorman, David C.

“…Dysosmia and anosmia are reported to occur following human exposure to hydrogen sulfide (H2S) gas. The clinical association between H2S exposure and olfactory…”
Get full text

Toxicity and occupational exposure assessment for hydroprocessed esters and fatty acids (HEFA) alternative jet fuels by Sterner, Teresa R., Wong, Brian A., Mumy, Karen L., James, R. Arden, Reboulet, James, Dodd, Darol E., Striebich, Richard C., Mattie, David R.

“…The U.S. Air Force (USAF) has pursued development of alternative fuels to augment or replace petroleum-based jet fuels. Hydroprocessed esters and fatty acids…”
Get full text

Acute and two-week inhalation toxicity studies in rats for Polyalphaolefin (PAO) fluid by Mattie, David R., Wegner, Matthew D., Wong, Brian A., James, R. Arden, Mumy, Karen L., McInturf, Shawn M., Marcel, Barry J., Sterner, Teresa R.

“…Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are utilized as aircraft hydraulics or…”
Get full text

Acute toxicity when concentration varies with time: A case study with carbon monoxide inhalation by rats by Sweeney, Lisa M., Sommerville, Douglas R., Goodwin, Michelle R., James, R. Arden, Channel, Stephen R.

“…Exposure to time-varying concentrations of toxic compounds is the norm in both occupational settings and daily human life, but little has been done to…”
Get full text

Neurotoxicological Effects Associated with Short-Term Exposure of Sprague–Dawley Rats to Hydrogen Sulfide by Struve, Melanie F, Brisbois, Jennifer N, Arden James, R, Marshall, Marianne W, Dorman, David C

“…Although hydrogen sulfide (H 2S) is a known neurotoxic hazard, only a limited number of experimental animal studies have examined its neurochemical or…”
Get full text

Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium by DORMAN, David C, MOULIN, Frederic J.-M, MCMANUS, Brian E, MAHLE, Kristen C, JAMES, R. Arden, STRUVE, Melanie F

“…Hydrogen sulfide (H2S) is an important brain, lung, and nose toxicant. Inhibition of cytochrome oxidase is the primary biochemical effect associated with…”
Get full text

Olfactory Mucosal Necrosis in Male CD Rats Following Acute Inhalation Exposure to Hydrogen Sulfide: Reversibility and the Possible Role of Regional Metabolism by Brenneman, Karrie A., Meleason, David F., Sar, Madhabananda, Marshall, Marianne W., James, R. Arden, Gross, Elizabeth A., Martin, Joseph T., Dorman, David C.

“…Hydrogen sulfide (H 2S) is a potent inhibitor of cytochrome oxidase (CO) and is associated with dysosmia and anosmia in humans and nasal lesions in exposed…”
Get full text

Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. I. Subacute exposures by Hardt, Daniel J., James, R. Arden, Gut, Chester P., McInturf, Shawn M., Sweeney, Lisa M., Erickson, Richard P., Gargas, Michael L.

“…Abstract The inhalation toxicity of submarine contaminants is of concern to ensure the health of men and women aboard submarines during operational…”
Get full text

Developmental toxicity evaluation of inhaled tertiary amyl methyl ether in mice and rats by Welsch, Frank, Elswick, Barbara, Arden James, R., Marr, Melissa C., Myers, Christina B., Tyl, Rochelle W.

“…This evaluation was part of a much more comprehensive testing program to characterize the mammalian toxicity potential of the gasoline oxygenator additive…”
Get full text

Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study by Hardt, Daniel J., James, R. Arden, Gut, Chester P., McInturf, Shawn M., Sweeney, Lisa M., Erickson, Richard P., Gargas, Michael L.

“…Abstract Carbon monoxide (CO), carbon dioxide (CO2) and low-level oxygen (O2) (hypoxia) are submarine atmosphere components of highest concern because of a…”
Get full text

Cognitive decline in older subjects by Nainar, Padma G, Green, David W, Arden, James R

Get full text

Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats by Dorman, David C, McManus, Brian E, Marshall, Marianne W, James, R.Arden, Struve, Melanie F

“…In this study, we examined whether gender or age influences the pharmacokinetics of manganese sulfate (MnSO 4) or manganese phosphate (as the mineral form…”
Get full text

Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment by Donner, E. Maria, Wong, Brian A., James, R. Arden, Preston, R. Julian

“…Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week)…”
Get full text

Tissue Manganese Concentrations in Lactating Rats and Their Offspring Following Combined in Utero and Lactation Exposure to Inhaled Manganese Sulfate by Dorman, David C., McElveen, Anna M., Marshall, Marianne W., Parkinson, Carl U., James, R. Arden, Struve, Melanie F., Wong, Brian A.

“…There is little information regarding the tissue distribution of manganese in neonates following inhalation. This study determined tissue manganese…”
Get full text

Development and use of a single-animal whole-body system for inhalation exposure by Wong, B.A, Ross, P.W, James, R.A

“…Inhalation exposure studies, in which test subjects are fully or partially immersed in an atmosphere containing a compound of interest, are usually carried out…”
Get full text

The Effect of Ethylene Exposure on Ethylene Oxide in Blood and on Hepatic Cytochrome P450 in Fischer Rats by Fennell, Timothy R., Snyder, Rodney W., Parkinson, Carl, Murphy, John, James, R. Arden

“…Ethylene (74-85-1) is an important petrochemical and is produced endogenously. It is metabolized to ethylene oxide (EO) by cytochrome P450. We studied the…”
Get full text

Respiration in Sprague-Dawley Rats During Pregnancy by Leavens, Teresa L., Parkinson, Carl U., James, R. Arden, House, Dennis, Elswick, Barbara, Dorman, David C.

“…Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their…”
Get full text

DEVELOPMENT OF AN INHALATION SYSTEM FOR THE SIMULTANEOUS EXPOSURE OF RAT DAMS AND PUPS DURING DEVELOPMENTAL NEUROTOXICITY STUDIES by Vitarella, Domenico

“…Due to mass flux constraints, the exposure of pups along with dams to particles cannot be easily done in traditional whole-body inhalation systems. Typical…”
Get full text