Search Results - "James, R W"

TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines by Ershov, Dmitry, Phan, Minh-Son, Pylvänäinen, Joanna W., Rigaud, Stéphane U., Le Blanc, Laure, Charles-Orszag, Arthur, Conway, James R. W., Laine, Romain F., Roy, Nathan H., Bonazzi, Daria, Duménil, Guillaume, Jacquemet, Guillaume, Tinevez, Jean-Yves

“…TrackMate is an automated tracking software used to analyze bioimages and is distributed as a Fiji plugin. Here, we introduce a new version of TrackMate…”
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Developments in preclinical cancer imaging: innovating the discovery of therapeutics by Conway, James R. W., Carragher, Neil O., Timpson, Paul

“…Key Points Advanced fluorescence-based imaging, three-dimensional intermediate systems and intravital mouse models can be integrated into the standard drug…”
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A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance by Al-Akhrass, Hussein, Conway, James R. W., Poulsen, Annemarie Svane Aavild, Paatero, Ilkka, Kaivola, Jasmin, Padzik, Artur, Andersen, Olav M., Ivaska, Johanna

“…Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted therapies is frequently associated with HER3 and…”
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Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan, Ivaska, Johanna

“…Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated…”
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SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers by Lilja, Johanna, Kaivola, Jasmin, Conway, James R. W., Vuorio, Joni, Parkkola, Hanna, Roivas, Pekka, Dibus, Michal, Chastney, Megan R., Varila, Taru, Jacquemet, Guillaume, Peuhu, Emilia, Wang, Emily, Pentikäinen, Ulla, Martinez D. Posada, Itziar, Hamidi, Hellyeh, Najumudeen, Arafath K., Sansom, Owen J., Barsukov, Igor L., Abankwa, Daniel, Vattulainen, Ilpo, Salmi, Marko, Ivaska, Johanna

“…The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS…”
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Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia by Feehan, Karen T., Bridgewater, Hannah E., Stenkiewicz-Witeska, Jan, De Maeyer, Roel P. H., Ferguson, John, Mack, Matthias, Brown, Jeremy, Ercoli, Giuseppe, Mawer, Connar M., Akbar, Arne N., Glanville, James R. W., Jalali, Parinaaz, Bracken, Olivia V., Nicolaou, Anna, Kendall, Alexandra C., Sugimoto, Michelle A., Gilroy, Derek W.

“…Resolving inflammation is thought to return the affected tissue back to homoeostasis but recent evidence supports a non-linear model of resolution involving a…”
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Effect of Bridge Alteration on Ground- and Excited-State Properties of Ruthenium(II) Complexes with Electron-Donor-Substituted Dipyrido[3,2‑a:2′,3′‑c]phenazine Ligands by Shillito, Georgina E, Larsen, Christopher B, McLay, James R. W, Lucas, Nigel T, Gordon, Keith C

“…A series of Ru­(II) 2,2′-bipyridine (bpy) complexes with an electron-accepting dipyrido­[3,2-a:2′,3′-c]­phenazine (dppz) ligand coupled to an electron-donating…”
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MASTL overexpression promotes chromosome instability and metastasis in breast cancer by Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Gallego-Ortega, David, Law, Andrew M. K., Chin, Venessa T., Conway, James R. W., Fey, Dirk, Millar, Ewan K. A., O’Toole, Sandra, Deng, Niantao, Swarbrick, Alexander, Chastain, Paul D., Cesare, Anthony J., Timpson, Paul, Caldon, C. Elizabeth, Croucher, David R., James, David E., Watkins, D. Neil, Burgess, Andrew

“…MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of…”
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Newly identified breast luminal progenitor and gestational stem cell populations likely give rise to HER2-overexpressing and basal-like breast cancers by McMullen, James R. W., Soto, Ubaldo

“…Breast Cancer (BrC) is a common malignancy with genetically diverse subtypes. There is evidence that specific BrC subtypes originate from particular normal…”
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Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan, Ivaska, Johanna

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The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking by Belle, Leila, Ali, Naveid, Lonic, Ana, Li, Xiaochun, Paltridge, James L, Roslan, Suraya, Herrmann, David, Conway, James R W, Gehling, Freya K, Bert, Andrew G, Crocker, Lesley A, Tsykin, Anna, Farshid, Gelareh, Goodall, Gregory J, Timpson, Paul, Daly, Roger J, Khew-Goodall, Yeesim

“…Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable…”
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MASTL promotes cell contractility and motility through kinase-independent signaling by Taskinen, Maria Emilia, Närvä, Elisa, Conway, James R W, Hinojosa, Laura Soto, Lilla, Sergio, Mai, Anja, De Franceschi, Nicola, Elo, Laura L, Grosse, Robert, Zanivan, Sara, Norman, Jim C, Ivaska, Johanna

“…Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accelerating kinase with emerging roles in cancer progression. However,…”
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IGFBP2 secretion by mammary adipocytes limits breast cancer invasion by Conway, James R W, Dinç, Defne D, Follain, Gautier, Paavolainen, Oona, Kaivola, Jasmin, Boström, Pia, Hartiala, Pauliina, Peuhu, Emilia, Ivaska, Johanna

“…The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a significantly poorer…”
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The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis by Ooms, Lisa M., Binge, Lauren C., Davies, Elizabeth M., Rahman, Parvin, Conway, James R.W., Gurung, Rajendra, Ferguson, Daniel T., Papa, Antonella, Fedele, Clare G., Vieusseux, Jessica L., Chai, Ryan C., Koentgen, Frank, Price, John T., Tiganis, Tony, Timpson, Paul, McLean, Catriona A., Mitchell, Christina A.

“…Metastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast…”
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Theoretical Foundation for Electric-Dipole-Allowed Chiral-Specific Fluorescence Optical Rotary Dispersion (F-ORD) from Interfacial Assemblies by Deng, Fengyuan, Ulcickas, James R. W, Simpson, Garth J

“…Fluorescence optical rotary dispersion (F-ORD) is proposed as a novel chiral-specific and interface-specific spectroscopic method. F-ORD measurements of…”
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Imaging the Nonlinear Susceptibility Tensor of Collagen by Nonlinear Optical Stokes Ellipsometry by Dow, Ximeng Y., DeWalt, Emma L., Sullivan, Shane Z., Schmitt, Paul D., Ulcickas, James R.W., Simpson, Garth J.

“…Nonlinear optical Stokes ellipsometric (NOSE) microscopy was demonstrated for the analysis of collagen-rich biological tissues. NOSE is based on…”
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The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells by Ortiz-Hernandez, Greisha L., Sanchez-Hernandez, Evelyn S., Ochoa, Pedro T., Elix, Catherine C., Alkashgari, Hossam R., McMullen, James R. W., Soto, Ubaldo, Martinez, Shannalee R., Diaz Osterman, Carlos J., Mahler, Michael, Roy, Sourav, Casiano, Carlos A.

“…Patients with prostate cancer (PCa) receiving docetaxel chemotherapy invariably develop chemoresistance. The transcription co-activator lens epithelium-derived…”
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Integrin adhesion complexes by Chastney, Megan R., Conway, James R.W., Ivaska, Johanna

“…Tissue architecture and function are orchestrated by an intricate repertoire of cellular adhesion and signalling receptors, and by the surrounding…”
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Climate change and the threat of novel marine predators in Antarctica by Smith, K. E., Aronson, R. B., Steffel, B. V., Amsler, M. O., Thatje, S., Singh, H., Anderson, J., Brothers, C. J., Brown, A., Ellis, D. S., Havenhand, J. N., James, W. R., Moksnes, P.‐O., Randolph, A. W., Sayre‐McCord, T., McClintock, J. B.

“…Historically low temperatures have severely limited skeleton‐breaking predation on the Antarctic shelf, facilitating the evolution of a benthic fauna poorly…”
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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse by Conway, James R W, Warren, Sean C, Lee, Young-Kyung, McCulloch, Andrew T, Magenau, Astrid, Lee, Victoria, Metcalf, Xanthe L, Stoehr, Janett, Haigh, Katharina, Abdulkhalek, Lea, Guaman, Cristian S, Reed, Daniel A, Murphy, Kendelle J, Pereira, Brooke A, Mélénec, Pauline, Chambers, Cecilia, Latham, Sharissa L, Lenthall, Helen, Deenick, Elissa K, Ma, Yuanqing, Phan, Tri, Lim, Elgene, Joshua, Anthony M, Walters, Stacey, Grey, Shane T, Shi, Yan-Chuan, Zhang, Lei, Herzog, Herbert, Croucher, David R, Philp, Andy, Scheele, Colinda L G J, Herrmann, David, Sansom, Owen J, Morton, Jennifer P, Papa, Antonella, Haigh, Jody J, Nobis, Max, Timpson, Paul

“…Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment of many…”
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