Search Results - "James, Michael G."

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein by Sonati, Tiziana, Reimann, Regina R., Falsig, Jeppe, Baral, Pravas Kumar, O’Connor, Tracy, Hornemann, Simone, Yaganoglu, Sine, Li, Bei, Herrmann, Uli S., Wieland, Barbara, Swayampakula, Mridula, Rahman, Muhammad Hafizur, Das, Dipankar, Kav, Nat, Riek, Roland, Liberski, Pawel P., James, Michael N. G., Aguzzi, Adriano

“…Biochemical and structural investigation of a model for prion-induced neurodegeneration—antibody binding to PrP C —reveals the role of the PrP flexible tail…”
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The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes by Polymenidou, Magdalini, Moos, Rita, Scott, Mike, Sigurdson, Christina, Shi, Yong-Zhong, Yajima, Bill, Hafner-Bratkovic, Iva, Jerala, Roman, Hornemann, Simone, Wuthrich, Kurt, Bellon, Anne, Vey, Martin, Garen, Graciela, James, Michael N G, Kav, Nat, Aguzzi, Adriano

“…PrP(Sc), a misfolded and aggregated form of the cellular prion protein PrP(C), is the only defined constituent of the transmissible agent causing prion…”
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Trends in implementation of evidence-based hip fracture management in a major Canadian city by Vergouwen, Martina, James, Michael G., You, Daniel Z., White, Neil J.

“…Abstract Aims: The importance of hip fracture care has resulted in an abundance of hip fracture management literature. The degree this evidence is incorporated…”
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crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis by Lemieux, M. Joanne, Fischer, Sarah J, Cherney, Maia M, Bateman, Katherine S, James, Michael N.G

“…Rhomboid peptidases are members of a family of regulated intramembrane peptidases that cleave the transmembrane segments of integral membrane proteins…”
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Transition of the prion protein from a structured cellular form (PrPC) to the infectious scrapie agent (PrPSc) by Baral, Pravas K., Yin, Jiang, Aguzzi, Adriano, James, Michael N. G.

“…Prion diseases in mammals are caused by a conformational transition of the cellular prion protein from its native conformation (PrPC) to a pathological isoform…”
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The synergistic potential of hydrogen inhalation and hyperbaric oxygen therapy by James, Michael G., Sehgal, Viren S.

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Structural Insights into Stereochemical Inversion by Diaminopimelate Epimerase: An Antibacterial Drug Target by Pillai, Bindu, Cherney, Maia M., Diaper, Christopher M., Sutherland, Andrew, Blanchard, John S., Vederas, John C., James, Michael N. G.

“…D-amino acids are much less common than their L-isomers but are widely distributed in most organisms. Many D-amino acids, including those necessary for…”
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The crystal structure of an octapeptide repeat of the Prion protein in complex with a Fab fragment of the POM2 antibody by Swayampakula, Mridula, Baral, Pravas Kumar, Aguzzi, Adriano, Kav, Nat N. V., James, Michael N. G.

“…ABSTRACT Prion diseases are progressive, infectious neurodegenerative disorders caused primarily by the misfolding of the cellular prion protein (PrPc) into an…”
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Reverse total shoulder arthroplasty for primary osteoarthritis with restricted preoperative forward elevation demonstrates similar outcomes but faster range of motion recovery compared to anatomic total shoulder arthroplasty by Karimi, Amin, Reddy, Rajiv P., Njoku-Austin, Confidence, Nazzal, Ehab, James, Michael G., Lin, Albert

“…Reverse total shoulder arthroplasty (RSA) has been increasingly utilized for a variety of shoulder pathologies that are difficult to treat with anatomical…”
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Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion by Baral, Pravas Kumar, Swayampakula, Mridula, Aguzzi, Adriano, James, Michael N. G.

“…Conversion of the cellular prion protein PrPC into its pathogenic isoform PrPSc is the hallmark of prion diseases, fatal neurodegenerative diseases affecting…”
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Site-directed mutagenesis of histidine 69 and glutamic acid 148 alters the ribonuclease activity of pea ABR17 (PR10.4) by Krishnaswamy, Sowmya, Baral, Pravas Kumar, James, Michael N.G., Kav, Nat N.V.

“…Pea abscisic acid responsive (ABR17) protein is a member of the pathogenesis-related 10 (PR10) family of proteins and its ribonuclease (RNase) activity has…”
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Reversing chronic pseudoparesis secondary to massive, irreparable rotator cuff tear: superior capsular reconstruction vs. reverse total shoulder arthroplasty by Reddy, Rajiv P., Herman, Zachary J., Como, Matthew, James, Michael G., Steuer, Fritz W., Adida, Samuel, Singh-Varma, Anya, Nazzal, Ehab M., Njoku-Austin, Confidence, Karimi, Amin, Lin, Albert

“…Recent studies have defined pseudoparesis as limited active forward elevation between 45° and 90° and maintained passive range of motion (ROM) in the setting…”
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Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite by Jacob-Ferreira, Anna Laura, Kondo, Marcia Yuri, Baral, Pravas Kumar, James, Michael N G, Holt, Andrew, Fan, Xiaohu, Schulz, Richard

“…Matrix metalloproteinase-2 (MMP-2) is a key intra- and extra-cellular protease which contributes to several oxidative stress related pathologies. A molecular…”
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Crystal Structure of Sulfide:Quinone Oxidoreductase from Acidithiobacillus ferrooxidans: Insights into Sulfidotrophic Respiration and Detoxification by Cherney, Maia M., Zhang, Yanfei, Solomonson, Matthew, Weiner, Joel H., James, Michael N.G.

“…Sulfide:quinone oxidoreductase from the acidophilic and chemolithotrophic bacterium Acidithiobacillus ferrooxidans was expressed in Escherichia coli and…”
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Crystal Structure of β-Hexosaminidase B in Complex with Pyrimethamine, a Potential Pharmacological Chaperone by Bateman, Katherine S, Cherney, Maia M, Mahuran, Don J, Tropak, Michael, James, Michael N. G

“…β-Hexosaminidases (β-hex) are a group of glycosyl hydrolase isozymes that break down neutral and sialylated glycosphingolipids in the lysosomes, thereby…”
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Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action by Huitema, Carly, Zhang, Jianmin, Yin, Jiang, James, Michael N.G., Vederas, John C., Eltis, Lindsay D.

“…The related 3C and 3C-like proteinase (3C pro and 3CL pro) of picornaviruses and coronaviruses, respectively, are good drug targets. As part of an effort to…”
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Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1 by Baral, Pravas Kumar, Wieland, Barbara, Swayampakula, Mridula, Polymenidou, Magdalini, Rahman, Muhammad Hafiz, Kav, Nat N. V., Aguzzi, Adriano, James, Michael N. G.

“…Prion diseases are neurodegenerative diseases characterized by the conversion of the cellular prion protein PrPc into a pathogenic isoform PrPsc. Passive…”
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Novel model for the induction of postnatal murine hip deformity by Killian, Megan L., Locke, Ryan C., James, Michael G., Atkins, Penny R., Anderson, Andrew E., Clohisy, John C.

“…ABSTRACT Acetabular dysplasia is a common, multi‐etiological, pre‐osteoarthritic (OA) feature that can lead to pain and instability of the young adult hip…”
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Around-The-Knee Osteotomies Part II: Surgical Indications, Techniques, and Outcomes - State of the Art by Lott, Ariana, James, Michael G, Kaarre, Janina, Höger, Svenja, Kayaalp, M Enes, Ollivier, Matthieu, Getgood, Al, Hughes, Jonathan D, Musahl, Volker

“…Recent advances in surgical techniques and planning for knee-based osteotomies have led to improvements in addressing lower extremity malalignment. Part 1 of…”
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Design, Synthesis, and Evaluation of Inhibitors for Severe Acute Respiratory Syndrome 3C-Like Protease Based on Phthalhydrazide Ketones or Heteroaromatic Esters by Zhang, Jianmin, Pettersson, Hanna I, Huitema, Carly, Niu, Chunying, Yin, Jiang, James, Michael N. G, Eltis, Lindsay D, Vederas, John C

“…The 3C-like protease (3CLpro), which controls the severe acute respiratory syndrome (SARS) coronavirus replication, has been identified as a potential target…”
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