Search Results - "James, Michael A"

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models by Tsai, Susan, McOlash, Laura, Palen, Katie, Johnson, Bryon, Duris, Christine, Yang, Qiuhui, Dwinell, Michael B, Hunt, Bryan, Evans, Douglas B, Gershan, Jill, James, Michael A

“…Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic…”
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Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus by James, Michael A, Wen, Weidong, Wang, Yian, Byers, Lauren A, Heymach, John V, Coombes, Kevin R, Girard, Luc, Minna, John, You, Ming

“…Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most…”
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CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis by JAMES, Michael A, VIKIS, Haris G, TATE, Everett, RYMASZEWSKI, Amy L, MING YOU

“…The transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer, where it protects tumor cells from genotoxic apoptosis. Here, we show that…”
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RGS17, an Overexpressed Gene in Human Lung and Prostate Cancer, Induces Tumor Cell Proliferation Through the Cyclic AMP-PKA-CREB Pathway by JAMES, Michael A, YAN LU, YAN LIU, VIKIS, Haris G, MING YOU

“…We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of…”
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Human Papillomavirus Type 16 E6 Activates NF-κB, Induces cIAP-2 Expression, and Protects against Apoptosis in a PDZ Binding Motif-Dependent Manner by JAMES, Michael A, LEE, John H, KLINGELHUTZ, Aloysius J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis by James, Michael A., Fu, Huijing, Liu, Yan, Chen, Da-Ren, You, Ming

“…Phellodendron amurense extract is a Chinese herbal remedy that has recently been studied for its antitumor, antimicrobial and other biological activities. It…”
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Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance by Parashar, Deepak, Geethadevi, Anjali, McAllister, Donna, Ebben, Johnathan, Peterson, Francis C., Jensen, Davin R., Bishop, Erin, Pradeep, Sunila, Volkman, Brian F., Dwinell, Michael B., Chaluvally-Raghavan, Pradeep, James, Michael A.

“…Recurrence of therapy-resistant tumors is a principal problem in solid tumor oncology, particularly in ovarian cancer. Despite common complete responses to…”
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HPV16‐E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300 by James, Michael A., Lee, John H., Klingelhutz, Aloysius J.

“…The E6 oncoprotein from high‐risk HPV types activates human telomerase reverse transcriptase (hTERT) transcription in human keratinocytes. Studies on how E6…”
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CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells by Clarke, William R., Amundadottir, Laufey, James, Michael A.

“…Altered regulation of endoplasmic reticulum (ER) homeostasis has been implicated in many cancers and has recently become a therapeutic and chemosensitization…”
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Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling by Puskás, László G, Mán, Imola, Szebeni, Gabor, Tiszlavicz, László, Tsai, Susan, James, Michael A

“…We and others have recently shown cisplatin resistance-related protein 9 (CRR9)/Cleft Lip and Palate Transmembrane 1-Like (CLPTM1L) to affect survival and…”
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Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines by Bodle, Christopher R, Mackie, Duncan I, Hayes, Michael P, Schamp, Josephine H, Miller, Michael R, Henry, Michael D, Doorn, Jonathan A, Houtman, Jon C. D, James, Michael A, Roman, David L

“…Regulator of G Protein Signaling (RGS) 17 is an overexpressed promoter of cancer survival in lung and prostate tumors, the knockdown of which results in…”
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A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression by James, Michael A, Seibel, William L, Kupert, Elena, Hu, Xiao X, Potharla, Vishwakanth Y, Anderson, Marshall W

“…The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential therapeutic agent that induces apoptosis selectively in tumor cells…”
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Haplotype and Cell Proliferation Analyses of Candidate Lung Cancer Susceptibility Genes on Chromosome 15q24-25.1 by YAN LIU, PENGYUAN LIU, PETERSEN, Gloria M, WIEST, Jonathan S, FAIN, Pamela R, SCHWARTZ, Ann G, GAZDAR, Adi, GABA, Colette, ROTHSCHILD, Henry, MANDAL, Diptasri, KUPERT, Elena, LEE, Juwon, WEIDONG WEN, SEMINARA, Daniela, MINNA, John, ANDERSON, Marshall W, MING YOU, JAMES, Michael A, YIAN WANG, BAILEY-WILSON, Joan E, AMOS, Christopher I, PINNEY, Susan M, PING YANG, DE ANDRADE, Mariza

“…Recent genome-wide association studies have linked the chromosome 15q24-25.1 locus to nicotine addiction and lung cancer susceptibility. To refine the…”
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Does Atrial Fibrillation Beget Ventricular Fibrillation in Patients with Acute Myocardial Infarction? by SANKARANARAYANAN, RAJIV, JAMES, MICHAEL A., NUTA, BOGDAN, TOWNSEND, MANDIE, KESAVAN, SUJATA, BURTCHAELL, STEPHANIE, HOLLOWAY, RUSSELL, EWINGS, B.Sc., M.Sc, PAUL

“…Background: Atrial fibrillation (AF) is associated with increased mortality and a higher complication rate postmyocardial infarction (MI), but the exact…”
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Use of a Retained Guidewire to Improve the Left Ventricular Pacing Threshold by SANKARANARAYANAN, RAJIV, JAMES, MICHAEL A.

“…Although transvenous access to the coronary veins has considerably simplified left ventricular (LV) pacing, it can remain a time consuming and arduous task…”
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Experimental Studies on Surface Roughness in Drilling MDF Composite Panels using Taguchi and Regression Analysis Method by Prakash, S, Mercy, J L, Palanikumar, K, Ramesh, S, Jamal, MIR, Michael, A J

“…Medium Density Fiber board (MDF) panels are appropriate for many exterior and interior industrial applications. The degree of surface roughness of MDF plays an…”
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Health outcomes. New quality measure for Medicare by COOPER, JAMES K., KOHLMANN, THOMAS, MICHAEL, JAMES A., HAFFER, SAMUEL C., STEVIC, MARCIA

“…Objective. A new measurement of health care quality for Medicare beneficiaries has been implemented by the Health Care Financing Administration (HCFA). This…”
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316L Stainless Steel Modified via Plasma Electrolytic Oxidation for Orthopedic Implants by Michael, James A

“…316L stainless steel (SS) is widely used biomaterial for implantable devices and is estimated to the base material for 60% of implantable devices. However, one…”
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Ventricular arrhythmia in untreated newly presenting hypertensive patients compared with matched normal population by James, M A, Jones, J V

“…There is evidence to suggest that hypertensive patients are at increased risk of sudden death. However, to date this evidence is restricted to treated…”
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Refocusing Advisories, Thematically by James, Michael A.

“…By coupling the creative synergy of a school's staff with some field-tested planning strategies, any advisory program can be improved and focused on students'…”
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