Search Results - "James, Matthew D."

Dyspnea in COPD: New Mechanistic Insights and Management Implications by O’Donnell, Denis E., Milne, Kathryn M., James, Matthew D., de Torres, Juan Pablo, Neder, J. Alberto

“…Dyspnea is the most common symptom experienced by patients with chronic obstructive pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt…”
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The Pathophysiology of Dyspnea and Exercise Intolerance in Chronic Obstructive Pulmonary Disease by O’Donnell, Denis E., James, Matthew D., Milne, Kathryn M., Neder, J. Alberto

“…Dyspnea, the most common symptom in chronic obstructive pulmonary disease (COPD), often becomes disabling in advanced stages of the disease. Chronic dyspnea…”
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Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema by Elbehairy, Amany F., Vincent, Sandra G., Phillips, Devin B., James, Matthew D., Veugen, Jenna, Parraga, Grace, O'Donnell, Denis E., Neder, J. Alberto

“…Reduced lung diffusing capacity for carbon monoxide (DL CO ) at rest and increased ventilation (⩒ E )-carbon dioxide output (⩒CO 2 ) during exercise are…”
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Beyond Spirometry: Linking Wasted Ventilation to Exertional Dyspnea in the Initial Stages of COPD by Neder, J Alberto, Santyr, Giles, Zanette, Brandon, Kirby, Miranda, Pourafkari, Marina, James, Matthew D, Vincent, Sandra G, Ferguson, Carrie, Wang, Chu-Yi, Domnik, Nicolle J, Phillips, Devin B, Porszasz, Janos, Stringer, William W, O'Donnell, Denis E

“…Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease (COPD), ultimately reflects an increased inspiratory neural drive to…”
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Dyspnea and Exercise Limitation in Mild COPD: The Value of CPET by James, Matthew D., Milne, Kathryn M., Phillips, Devin B., Neder, J. Alberto, O'Donnell, Denis E.

“…The majority of smokers with chronic obstructive pulmonary disease (COPD) have mild airflow limitation as determined by simple spirometry. Although small…”
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Evaluation of Dynamic Respiratory Mechanical Abnormalities During Conventional CPET by Milne, Kathryn M., Domnik, Nicolle J., Phillips, Devin B., James, Matthew D., Vincent, Sandra G., Neder, J. Alberto, O'Donnell, Denis E.

“…Assessment of the ventilatory response to exercise is important in evaluating mechanisms of dyspnea and exercise intolerance in chronic cardiopulmonary…”
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Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms by James, Matthew D., Phillips, Devin B., Vincent, Sandra G., Abdallah, Sara J., Donovan, Adamo A., de‐Torres, Juan P., Neder, J. Alberto, Smith, Benjamin M., Jensen, Dennis, O'Donnell, Denis E.

“…In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea generally arises when there is imbalance between ventilatory demand and…”
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Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease by Elbehairy, Amany F, O'Donnell, Conor D, Abd Elhameed, Asmaa, Vincent, Sandra G, Milne, Kathryn M, James, Matthew D, Webb, Katherine A, Neder, J Alberto, O'Donnell, Denis E

“…The mechanisms linking reduced diffusing capacity of the lung for carbon monoxide (Dl ) to dyspnea and exercise intolerance across the chronic obstructive…”
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Mechanisms of orthopnoea in patients with advanced COPD by Elbehairy, Amany F, Faisal, Azmy, McIsaac, Hannah, Domnik, Nicolle J, Milne, Kathryn M, James, Matthew D, Neder, J Alberto, O'Donnell, Denis E

“…Many patients with severe chronic obstructive pulmonary disease (COPD) report an unpleasant respiratory sensation at rest, which is further amplified by…”
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Qualitative Components of Dyspnea during Incremental Exercise across the COPD Continuum by PHILLIPS, DEVIN B., NEDER, J. ALBERTO, ELBEHAIRY, AMANY F., MILNE, KATHRYN M., JAMES, MATTHEW D., VINCENT, SANDRA G., DAY, ANDREW G., DE-TORRES, JUAN P., WEBB, KATHERINE A., O’DONNELL, DENIS E.

“…Evaluation of the intensity and quality of activity-related dyspnea is potentially useful in people with chronic obstructive pulmonary disease (COPD). The…”
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Physiological predictors of morbidity and mortality in COPD: the relative importance of reduced inspiratory capacity and inspiratory muscle strength by Phillips, Devin B., James, Matthew D., O’Donnell, Conor D., Vincent, Sandra G., Webb, Katherine A., de-Torres, Juan P., Neder, J. Alberto, O’Donnell, Denis E.

“…To our knowledge, this study is the first to show an independent association between low resting inspiratory capacity (IC) and, severe exertional dyspnea,…”
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Dynamic Ventilatory Reserve During Incremental Exercise: Reference Values and Clinical Validation in Chronic Obstructive Pulmonary Disease by Berton, Danilo C., Plachi, Franciele, James, Matthew D., Vincent, Sandra G., Smyth, Reginald M., Domnik, Nicolle J., Phillips, Devin B., de-Torres, Juan P., Nery, Luiz E., O’Donnell, Denis E., Neder, J. Alberto

“…Berton et al discuss their study on dynamic ventilatory reserve during incremental exercise in chronic obstructive pulmonary disease (COPD). After establishing…”
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Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study by Phillips, Devin B, Elbehairy, Amany F, James, Matthew D, Vincent, Sandra G, Milne, Kathryn M, de-Torres, Juan P, Neder, J Alberto, Kirby, Miranda, Jensen, Dennis, Stickland, Michael K, Guenette, Jordan A, Smith, Benjamin M, Aaron, Shawn D, Tan, Wan C, Bourbeau, Jean, O'Donnell, Denis E

“…Impaired exercise ventilatory efficiency (high ventilatory requirements for CO [[Formula: see text]e/[Formula: see text]co ]) provides an indication of…”
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Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance by Phillips, Devin B, James, Matthew D, Vincent, Sandra G, Elbehairy, Amany F, Neder, J Alberto, Kirby, Miranda, Ora, Josuel, Day, Andrew G, Tan, Wan C, Bourbeau, Jean, O'Donnell, Denis E

“…It is increasingly recognized that adults with preserved ratio impaired spirometry (PRISm) are prone to increased morbidity. However, the underlying…”
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Neurophysiological mechanisms of exertional dyspnea in post-pulmonary embolism syndrome by Milne, Kathryn M, James, Matthew D, Smyth, Reginald M, Vincent, Sandra G, Singh, Namisha, D'Arsigny, Christine L, de-Torres, Juan P, de Wit, Kerstin, Johri, Amer, Neder, J Alberto, O'Donnell, Denis E, Phillips, Devin B

“…Following pulmonary embolism (PE), a third of patients develop persistent dyspnea, which is commonly termed the post-PE syndrome. The neurophysiological…”
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Systemic Determinants of Exercise Intolerance in Patients With Fibrotic Interstitial Lung Disease and Severely Impaired DLCO by Smyth, Reginald M, James, Matthew D, Vincent, Sandra G, Milne, Kathryn M, Marillier, Mathieu, Domnik, Nicolle J, Parker, Christopher M, de-Torres, Juan P, Moran-Mendoza, Onofre, Phillips, Devin B, O'Donnell, Denis E, Neder, J Alberto

“…The precise mechanisms driving poor exercise tolerance in patients with fibrotic interstitial lung diseases (fibrotic ILDs) showing a severe impairment in…”
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Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency by Phillips, Devin B., James, Matthew D., Elbehairy, Amany F., Milne, Kathryn M., Vincent, Sandra G., Domnik, Nicolle J., de‐Torres, Juan P., Neder, J. Alberto, O'Donnell, Denis E.

“…Background and objective The combination of both reduced resting diffusing capacity of the lung for carbon monoxide (DLCO) and ventilatory efficiency…”
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Physiological underpinnings of exertional dyspnoea in mild fibrosing interstitial lung disease by Smyth, Reginald M., Neder, J. Alberto, James, Matthew D., Vincent, Sandra G., Milne, Kathryn M., Marillier, Mathieu, de-Torres, Juan P., Moran-Mendoza, Onofre, O’Donnell, Denis E., Phillips, Devin B.

“…The functional disturbances driving “out-of-proportion” dyspnoea in patients with fibrosing interstitial lung disease (f-ILD) showing only mild restrictive…”
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Elevated exercise ventilation in mild COPD is not linked to enhanced central chemosensitivity by Phillips, Devin B, Domnik, Nicolle J, Elbehairy, Amany F, Preston, Megan E, Milne, Kathryn M, James, Matthew D, Vincent, Sandra G., Ibrahim-Masthan, Megha, Neder, J Alberto, O’Donnell, Denis E

“…The purpose of this study was to determine if altered central chemoreceptor characteristics contributed to the elevated ventilation relative to carbon dioxide…”
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Inspiratory neural drive and dyspnea in interstitial lung disease: Effect of inhaled fentanyl by Milne, Kathryn M., Ibrahim-Masthan, Megha, Scheeren, Robin E., James, Matthew D., Phillips, Devin B., Moran-Mendoza, Onofre, JA, Neder, O’Donnell, Denis E.

“…•Resting lung function tests underestimate physiologic impairment during exercise in interstitial lung disease.•Exertional dyspnea in interstitial lung disease…”
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