Search Results - "James, M.A."

Meiotic Silencing in Mammals by Turner, James M.A

“…Meiosis is essential for reproduction in sexually reproducing organisms. A key stage in meiosis is the synapsis of maternal and paternal homologous…”
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Enhancer Evolution across 20 Mammalian Species by Villar, Diego, Berthelot, Camille, Aldridge, Sarah, Rayner, Tim F., Lukk, Margus, Pignatelli, Miguel, Park, Thomas J., Deaville, Robert, Erichsen, Jonathan T., Jasinska, Anna J., Turner, James M.A., Bertelsen, Mads F., Murchison, Elizabeth P., Flicek, Paul, Odom, Duncan T.

“…The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory…”
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Gene expression across mammalian organ development by Cardoso-Moreira, Margarida, Halbert, Jean, Valloton, Delphine, Velten, Britta, Chen, Chunyan, Shao, Yi, Liechti, Angélica, Ascenção, Kelly, Rummel, Coralie, Ovchinnikova, Svetlana, Mazin, Pavel V., Xenarios, Ioannis, Harshman, Keith, Mort, Matthew, Cooper, David N., Sandi, Carmen, Soares, Michael J., Ferreira, Paula G., Afonso, Sandra, Carneiro, Miguel, Turner, James M. A., VandeBerg, John L., Fallahshahroudi, Amir, Jensen, Per, Behr, Rüdiger, Lisgo, Steven, Lindsay, Susan, Khaitovich, Philipp, Huber, Wolfgang, Baker, Julie, Anders, Simon, Zhang, Yong E., Kaessmann, Henrik

“…The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum,…”
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Sex Chromosome Effects on Male–Female Differences in Mammals by Snell, Daniel M., Turner, James M.A.

“…Fundamental differences exist between males and females, encompassing anatomy, physiology, behaviour, and genetics. Such differences undoubtedly play a part in…”
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Human Embryogenesis: A Comparative Perspective by Gerri, Claudia, Menchero, Sergio, Mahadevaiah, Shantha K, Turner, James M.A, Niakan, Kathy K

“…Understanding human embryology has historically relied on comparative approaches using mammalian model organisms. With the advent of low-input methods to…”
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A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation by Mahadevaiah, Shantha K., Sangrithi, Mahesh N., Hirota, Takayuki, Turner, James M. A.

“…Single-cell RNA sequencing of embryos can resolve the transcriptional landscape of development at unprecedented resolution. To date, single-cell RNA-sequencing…”
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The consequences of asynapsis for mammalian meiosis by Burgoyne, Paul S, Mahadevaiah, Shantha K, Turner, James M. A

“…In mammals, errors in synapsis are associated with impaired meiosis, which is male-biased and is associated with reduced fertility. The recent discovery that…”
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SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice by Hirota, Takayuki, Blakeley, Paul, Sangrithi, Mahesh N., Mahadevaiah, Shantha K., Encheva, Vesela, Snijders, Ambrosius P., ElInati, Elias, Ojarikre, Obah A., de Rooij, Dirk G., Niakan, Kathy K., Turner, James M.A.

“…Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologs are transcriptionally inactivated by meiotic…”
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Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline by Sangrithi, Mahesh N., Royo, Helene, Mahadevaiah, Shantha K., Ojarikre, Obah, Bhaw, Leena, Sesay, Abdul, Peters, Antoine H.F.M., Stadler, Michael, Turner, James M.A.

“…Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation,…”
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Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms by Wojtasz, Lukasz, Cloutier, Jeffrey M, Baumann, Marek, Daniel, Katrin, Varga, János, Fu, Jun, Anastassiadis, Konstantinos, Stewart, A Francis, Reményi, Attila, Turner, James M A, Tóth, Attila

“…Meiotic crossover formation involves the repair of programmed DNA double-strand breaks (DSBs) and synaptonemal complex (SC) formation. Completion of these…”
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ATR is a multifunctional regulator of male mouse meiosis by Widger, Alexander, Mahadevaiah, Shantha K., Lange, Julian, ElInati, Elias, Zohren, Jasmin, Hirota, Takayuki, Pacheco, Sarai, Maldonado-Linares, Andros, Stanzione, Marcello, Ojarikre, Obah, Maciulyte, Valdone, de Rooij, Dirk G., Tóth, Attila, Roig, Ignasi, Keeney, Scott, Turner, James M.A.

“…Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the…”
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The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression by Mueller, Jacob L, Turner, James M A, Mahadevaiah, Shantha K, Park, Peter J, Warburton, Peter E, Page, David C

“…According to the prevailing view, mammalian X chromosomes are enriched in spermatogenesis genes expressed before meiosis and deficient in spermatogenesis genes…”
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Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation by Grant, Jennifer, Mahadevaiah, Shantha K., Khil, Pavel, Sangrithi, Mahesh N., Royo, Hélène, Duckworth, Janine, McCarrey, John R., VandeBerg, John L., Renfree, Marilyn B., Taylor, Willie, Elgar, Greg, Camerini-Otero, R. Daniel, Gilchrist, Mike J., Turner, James M. A.

“…A non-coding RNA termed Rsx , which has properties consistent with a role in X-chromosome inactivation, is identified in the marsupial Monodelphis domestica …”
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Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals by Cloutier, Jeffrey M, Mahadevaiah, Shantha K, ElInati, Elias, Nussenzweig, André, Tóth, Attila, Turner, James M A

“…Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are…”
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ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing by Royo, Hélène, Prosser, Haydn, Ruzankina, Yaroslava, Mahadevaiah, Shantha K, Cloutier, Jeffrey M, Baumann, Marek, Fukuda, Tomoyuki, Höög, Christer, Tóth, Attila, de Rooij, Dirk G, Bradley, Allan, Brown, Eric J, Turner, James M A

“…In mammals, homologs that fail to synapse during meiosis are transcriptionally inactivated. This process, meiotic silencing, drives inactivation of the…”
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Recombinational DNA double-strand breaks in mice precede synapsis by Turner, James M.A, Jasin, Maria, Bonner, William M, Baudat, Frédéric, Blanco-Rodríguez, Josefa, Rogakou, Emmy P, de Boer, Peter, Mahadevaiah, Shantha K, Keeney, Scott, Burgoyne, Paul S

“…In Saccharomyces cerevisiae, meiotic recombination is initiated by Spo11-dependent double-strand breaks (DSBs), a process that precedes homologous synapsis…”
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Pachytene Asynapsis Drives Meiotic Sex Chromosome Inactivation and Leads to Substantial Postmeiotic Repression in Spermatids by Turner, James M.A., Mahadevaiah, Shantha K., Ellis, Peter J.I., Mitchell, Michael J., Burgoyne, Paul S.

“…Transcriptional silencing of the sex chromosomes during male meiosis (MSCI) is conserved among organisms with limited sex chromosome synapsis, including…”
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BRCA1, Histone H2AX Phosphorylation, and Male Meiotic Sex Chromosome Inactivation by Turner, James M.A., Aprelikova, Olga, Xu, Xiaoling, Wang, Ruihong, Kim, Sangsoo, Chandramouli, Gadisetti V.R., Barrett, J.Carl, Burgoyne, Paul S., Deng, Chu-Xia

“…In mammalian spermatogenesis, the X and Y chromosomes are transcriptionally silenced during the pachytene stage of meiotic prophase (meiotic sex chromosome…”
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Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation by Royo, Hélène, Seitz, Hervé, ElInati, Elias, Peters, Antoine H F M, Stadler, Michael B, Turner, James M A

“…During the pachytene stage of meiosis in male mammals, the X and Y chromosomes are transcriptionally silenced by Meiotic Sex Chromosome Inactivation (MSCI)…”
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Error-prone ZW pairing and no evidence for meiotic sex chromosome inactivation in the chicken germ line by Guioli, Silvana, Lovell-Badge, Robin, Turner, James M A

“…In the male mouse the X and Y chromosomes pair and recombine within the small pseudoautosomal region. Genes located on the unsynapsed segments of the X and Y…”
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