Search Results - "James, Kieran D."

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells by Lucas, Beth, White, Andrea J., Cosway, Emilie J., Parnell, Sonia M., James, Kieran D., Jones, Nick D., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Anderson, Graham

“…The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly…”
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Redefining thymus medulla specialization for central tolerance by Cosway, Emilie J, Lucas, Beth, James, Kieran D, Parnell, Sonia M, Carvalho-Gaspar, Manuela, White, Andrea J, Tumanov, Alexei V, Jenkinson, William E, Anderson, Graham

“…During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to…”
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Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD by Alawam, Abdullah S, Cosway, Emilie J, James, Kieran D, Lucas, Beth, Bacon, Andrea, Parnell, Sonia M, White, Andrea J, Jenkinson, William E, Anderson, Graham

“…Bone marrow transplantation (BMT) is a widely used therapy for blood cancers and primary immunodeficiency. Following transplant, the thymus plays a key role in…”
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Non-Epithelial Stromal Cells in Thymus Development and Function by James, Kieran D, Jenkinson, William E, Anderson, Graham

“…The thymus supports T-cell development specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. These…”
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The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration by Cosway, Emilie J., James, Kieran D., White, Andrea J., Parnell, Sonia M., Bacon, Andrea, McKenzie, Andrew N. J., Jenkinson, W. E., Anderson, Graham

“…As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus…”
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Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla by Lucas, Beth, White, Andrea J., Klein, Fabian, Veiga-Villauriz, Clara, Handel, Adam, Bacon, Andrea, Cosway, Emilie J., James, Kieran D., Parnell, Sonia M., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Hollander, Georg A., Lu, Wei-Yu, Anderson, Graham

“…The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic…”
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T‐cell egress from the thymus: Should I stay or should I go? by James, Kieran D., Jenkinson, William E., Anderson, Graham

“…T‐cells bearing the αβTCR play a vital role in defending the host against foreign pathogens and malignant transformation of self. Importantly, T‐cells are…”
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Generation and repair of thymic epithelial cells by Anderson, Graham, Cosway, Emilie J, James, Kieran D, Ohigashi, Izumi, Takahama, Yousuke

“…In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of…”
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The medulla controls effector primed γδT‐cell development in the adult mouse thymus by James, Kieran D., White, Andrea J., Jenkinson, William E., Anderson, Graham

“…γδT cells are produced in the thymus throughout life and provide immunity at epithelial‐rich sites. Unlike conventional αβT cells, γδT‐cell development…”
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Assembling the thymus medulla: Development and function of epithelial cell heterogeneity by James, Kieran D., Cosway, Emilie J., Parnell, Sonia M., White, Andrea J., Jenkinson, William E., Anderson, Graham

“…The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic…”
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The thymus medulla and its control of αβT cell development by Cosway, Emilie J., James, Kieran D., Lucas, Beth, Anderson, Graham, White, Andrea J.

“…αβT cells are an essential component of effective immune responses. The heterogeneity that lies within them includes subsets that express diverse…”
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Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk by White, Andrea J, Parnell, Sonia M, Handel, Adam, Maio, Stefano, Bacon, Andrea, Cosway, Emilie J, Lucas, Beth, James, Kieran D, Cowan, Jennifer E, Jenkinson, William E, Hollander, Georg A, Anderson, Graham

“…In the thymus, cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells support αβT cell development from lymphoid progenitors. For…”
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Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus by Lucas, Beth, James, Kieran D, Cosway, Emilie J, Parnell, Sonia M, Tumanov, Alexi V, Ware, Carl F, Jenkinson, William E, Anderson, Graham

“…The recruitment of lymphoid progenitors to the thymus is essential to sustain T cell production throughout life. Importantly, it also limits T lineage…”
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Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration by James, Kieran D, Cosway, Emilie J, Lucas, Beth, White, Andrea J, Parnell, Sonia M, Carvalho-Gaspar, Manuela, Tumanov, Alexei V, Anderson, Graham, Jenkinson, William E

“…The emigration of mature thymocytes from the thymus is critical for establishing peripheral T cell compartments. However, the pathways controlling this process…”
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Control of the thymic medulla and its influence on alpha beta T-cell development by Lucas, Beth, McCarthy, Nicholas I, Baik, Song, Cosway, Emilie, James, Kieran D, Parnell, Sonia M, White, Andrea J, Jenkinson, William E, Anderson, Graham

“…The thymus is a primary lymphoid tissue that supports the generation of alpha beta T cells. In this review, we describe the processes that give rise to the…”
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Control of the thymic medulla and its influence on αβT-cell development by Lucas, Beth, McCarthy, Nicholas I., Baik, Song, Cosway, Emilie, James, Kieran D., Parnell, Sonia M., White, Andrea J., Jenkinson, William E., Anderson, Graham

“…Summary The thymus is a primary lymphoid tissue that supports the generation of αβT cells. In this review, we describe the processes that give rise to the…”
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Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus by James, Kieran D., Legler, Daniel F., Purvanov, Vladimir, Ohigashi, Izumi, Takahama, Yousuke, Parnell, Sonia M., White, Andrea J., Jenkinson, William E., Anderson, Graham

“…The release of newly selected αβT cells from the thymus is key in establishing a functional adaptive immune system. Emigration of the first cohorts of αβT…”
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NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome by Chen, Rui, Lukianova, Elena, van der Loeff, Ina Schim, Spegarova, Jarmila Stremenova, Willet, Joseph D P, James, Kieran D, Ryder, Edward J, Griffin, Helen, IJspeert, Hanna, Gajbhiye, Akshada, Lamoliatte, Frederic, Marin-Rubio, Jose L, Woodbine, Lisa, Lemos, Henrique, Swan, David J, Pintar, Valeria, Sayes, Kamal, Ruiz-Morales, Elias R, Eastham, Simon, Dixon, David, Prete, Martin, Prigmore, Elena, Jeggo, Penny, Boyes, Joan, Mellor, Andrew, Huang, Lei, van der Burg, Mirjam, Engelhardt, Karin R, Stray-Pedersen, Asbjørg, Erichsen, Hans Christian, Gennery, Andrew R, Trost, Matthias, Adams, David J, Anderson, Graham, Lorenc, Anna, Trynka, Gosia, Hambleton, Sophie

“…Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 11 affected patients…”
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Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk by White, Andrea J, Parnell, Sonia M, Handel, Adam, Maio, Stefano, Bacon, Andrea, Cosway, Emilie J, Lucas, Beth, James, Kieran D, Cowan, Jennifer E, Jenkinson, William E, Hollander, Georg A, Anderson, Graham

“…In the thymus, cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells support αβT cell development from lymphoid progenitors. For…”
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