Search Results - "James, Jithu"

Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet by Varghese, Joe, James, Jithu V, Anand, R, Narayanasamy, Muthuraman, Rebekah, Grace, Ramakrishna, Banumathi, Nellickal, Arun Jose, Jacob, Molly

“…Type 2 diabetes mellitus (T2DM) and insulin resistance (IR) have been associated with dysregulation of iron metabolism. The basis for this association is not…”
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Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics by Venkatesan, Padmanaban, Varghese, Joe, Arthi, T.S., James, Jithu V., Anura, Anji, Prasad, Jasmin, Jacob, Molly

“…Diabetes mellitus has been reported to be associated with increased serum levels of ferritin. The basis of this association is unclear. It is also not…”
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Migratory chondroprogenitors retain superior intrinsic chondrogenic potential for regenerative cartilage repair as compared to human fibronectin derived chondroprogenitors by Vinod, Elizabeth, Johnson, Noel Naveen, Kumar, Sanjay, Amirtham, Soosai Manickam, James, Jithu Varghese, Livingston, Abel, Rebekah, Grace, Daniel, Alfred Job, Ramasamy, Boopalan, Sathishkumar, Solomon

“…Cell-based therapy for articular hyaline cartilage regeneration predominantly involves the use of mesenchymal stem cells and chondrocytes. However, the…”
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Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice by James, Jithu V., Varghese, Joe, Mckie, Andrew T., Vaulont, Sophie, Jacob, Molly

“…Increased body iron stores have been implicated in the pathogenesis of diabetes mellitus. However, the molecular mechanisms involved are unclear. The liver…”
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Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells by Vinod, Elizabeth, Parasuraman, Ganesh, Lisha J, Jeya, Amirtham, Soosai Manickam, Livingston, Abel, Varghese, Jithu James, Rani, Sandya, Francis, Deepak Vinod, Rebekah, Grace, Daniel, Alfred Job, Ramasamy, Boopalan, Sathishkumar, Solomon

“…Obtaining regeneration-competent cells and generating high-quality neocartilage are still challenges in articular cartilage tissue engineering. Although…”
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Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney by Nagappan, Arumugam Suriyam, Varghese, Joe, James, Jithu V., Jacob, Molly

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice. However, their use is often associated with adverse effects in the…”
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Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease by Varghese, Joe, Varghese James, Jithu, Karthikeyan, Mathuravalli, Rasalkar, Kavita, Raghavan, Ramya, Sukumaran, Abitha, Premkumar, Prasanna S., Eapen, CE, Jacob, Molly

“…Perturbations in iron homeostasis have been reported to be associated with irreversible liver injury in chronic liver disease (CLD). However, it is not clear…”
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Development of Zeolite‐Loaded Air‐Brushed Nanofibers for Oral Use and Its Characterization by Shakir, Arshiya, C, Pushpalatha, Deveswaran, R., Jerin James, Jithu

“…Zeolites are commercially available and naturally occurring minerals and synthetic materials, they are crystalline aluminosilicates with distinctive chemical…”
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Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin by Varghese, Joe, James, Jithu, Vaulont, Sophie, Mckie, Andrew, Jacob, Molly

“…An iron-overloaded state has been reported to be associated with insulin resistance. On the other hand, conditions such as classical hemochromatosis (where…”
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Hepcidin-Ferritin Ratio Is Decreased In Diabetes Mellitus by Padmanabhan, V, Varghese, Joe, James, Jithu, Prasad, Jasmine, Jacob, Molly

“…On univariate analysis, serum ferritin showed known significant correlations with other parameters of iron metabolism. Fasting plasma glucose levels correlated…”
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Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin by James, Jithu Varghese, Varghese, Joe, John, Nikhitha Mariya, Deschemin, Jean-Christophe, Vaulont, Sophie, McKie, Andrew Tristan, Jacob, Molly

“…Increased body iron stores and inflammation in adipose tissue have been implicated in the pathogenesis of insulin resistance (IR) and type 2 diabetes mellitus…”
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A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PYRANTEL PAMOATE AND PRAZIQUANTEL IN BULK AND PHARMACEUTICAL DOSAGE FORM by R., Rajesh, JERIN JAMES, JITHU

“…Objective: To develop a simple, accurate and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method and subsequently validate for the…”
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Articular chondroprogenitors in platelet rich plasma for treatment of osteoarthritis and osteochondral defects in a rabbit knee model by Vinod, Elizabeth, Amirtham, Soosai Manickam, Kachroo, Upasana, Goyal, Anjali, Ozbey, Ozlem, James, Jithu Varghese, Sathishkumar, Solomon, Ramasamy, Boopalan

“…[Display omitted] •Assess healing of experimentally created osteoarthritis and osteochondral defect in a rabbit model.•Osteoarthritis group: treatment with…”
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Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin by Varghese, Joe, James, Jithu Varghese, Sagi, Sreerohini, Chakraborty, Subhosmito, Sukumaran, Abitha, Ramakrishna, Banumathi, Jacob, Molly

“…Hepatic Fe overload has often been reported in patients with advanced alcoholic liver disease. However, it is not known clearly whether it is the effect of…”
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The iron-hepcidin axis is intact in patients with chronic liver disease by James, Jithu, Varghese, Joe, Mathuravalli, K, Rasalkar, Kavita, Raghavan, Ramya, Eapen, C.E, Jacob, Molly

“…When CLD patients were categorized into those with high (HiFe) and low (LoFe) serum ferritin levels (serum ferritin levels [less than or equal to] 300…”
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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis by James, Jithu Jerin, Sandhya, K. V., Sridhar, K. N., Sudarson, S., Basavaraj, B. V., Bharath, S.

“…Biologics have become increasingly prominent as therapeutics in recent years due to their innate immune-privileged nature, biocompatibility, and high levels of…”
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Comparison of incremental concentrations of micron-sized superparamagnetic iron oxide for labelling articular cartilage derived chondroprogenitors by Vinod, Elizabeth, James, Jithu Varghese, Kachroo, Upasana, Sathishkumar, Solomon, Livingston, Abel, Ramasamy, Boopalan

“…•First study where M-SPIO was used to label human articular cartilage derived CPs.•12.75 μg/ml M-SPIO labelled CPs with minimal effect on viability and…”
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Prospective Isolation and Characterization of Chondroprogenitors from Human Chondrocytes Based on CD166/CD34/CD146 Surface Markers by Vinod, Elizabeth, Padmaja, Kawin, Livingston, Abel, James, Jithu Varghese, Amirtham, Soosai Manickam, Sathishkumar, Solomon, Ramasamy, Boopalan, Rebekah, Grace, Daniel, Alfred Job, Kachroo, Upasana

“…Purpose Chondrocytes, isolated from articular cartilage, are routinely utilized in cell-based therapeutics for the treatment of cartilage pathologies. However,…”
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Human fetal cartilage-derived chondrocytes and chondroprogenitors display a greater commitment to chondrogenesis than adult cartilage resident cells by Elizabeth Vinod, Ganesh Parasuraman, Jeya Lisha J., Soosai Manickam Amirtham, Abel Livingston, Jithu James Varghese, Sandya Rani, Deepak Vinod Francis, Grace Rebekah, Alfred Job Daniel, Boopalan Ramasamy, Solomon Sathishkumar

“…Obtaining regeneration-competent cells and generating high-quality neocartilage are still challenges in articular cartilage tissue engineering. Although…”
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Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders by SUKUMARAN, Abitha, JAMES, Jithu, HARISH PALLETI JANARDHAN, AMALADAS, Anita, LEKSHMY MADATHILAZHIKATHU SURESH, DANDA, Debashish, JEYESEELAN, Visalakshi, BALAKRISHNAN SIDDHARTH RAMAKRISHNA, JACOB, Molly

“…Mechanisms responsible for derangements in Fe homeostasis in chronic inflammatory conditions are not entirely clear. The aim of the present study was to test…”
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