Search Results - "James, J.W."

Single and parallel machine capacitated lotsizing and scheduling: New iterative MIP-based neighborhood search heuristics by James, Ross J.W., Almada-Lobo, Bernardo

“…We propose a general-purpose heuristic approach combining metaheuristics and mixed integer programming to find high quality solutions to the challenging…”
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Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2 by Bell, Joseph A., Davies, Elizabeth R., Brereton, Christopher J., Vukmirovic, Milica, Roberts, James J.W., Lunn, Kerry, Wickens, Leanne, Conforti, Franco, Ridley, Robert A., Ceccato, Jessica, Sayer, Lucy N., Johnston, David A., Vallejo, Andres F., Alzetani, Aiman, Jogai, Sanjay, Marshall, Ben G., Fabre, Aurelie, Richeldi, Luca, Monk, Phillip D., Skipp, Paul, Kaminski, Naftali, Offer, Emily, Wang, Yihua, Davies, Donna E., Jones, Mark G.

“…Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis…”
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Symmetry of hip dysplasia traits in the German Shepherd Dog in Australia by Wilson, B.J, Nicholas, F.W, James, J.W, Wade, C.M, Tammen, I, Raadsma, H.W, Castle, K, Thomson, P.C

“…Canine hip dysplasia (CHD) is a common and debilitating developmental condition of the canine coxofemoral (hip) joint, exhibiting a multifactorial pattern of…”
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Call to Service: Innovation Needed to Improve Recruiting, Retention by Clarke, James J.W

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A pedigree-analysis approach to the descriptive epidemiology of autosomal-recessive disorders by Man, W.Y.N., Nicholas, F.W., James, J.W.

“…We describe a pedigree-analysis approach to estimating descriptive epidemiological parameters for autosomal-recessive disorders when the ancestral source of…”
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Edge chipping and flexural resistance of monolithic ceramics by Zhang, Yu, Lee, James J.-W, Srikanth, Ramanathan, Lawn, Brian R

“…Abstract Objective Test the hypothesis that monolithic ceramics can be developed with combined esthetics and superior fracture resistance to circumvent…”
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Entropy-Based Optimization of Nonlinear Separable Discrete Decision Models by Nakagawa, Yuji, James, Ross J. W., Rego, César, Edirisinghe, Chanaka

“…This paper develops a new way to help solve difficult linear and nonlinear discrete-optimization decision models more efficiently by introducing a…”
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Remarkable resilience of teeth by Chai, Herzl, Lee, James J.-W, Constantino, Paul J, Lucas, Peter W, Lawn, Brian R

“…Tooth enamel is inherently weak, with fracture toughness comparable with glass, yet it is remarkably resilient, surviving millions of functional contacts over…”
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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches by Xiao, Hai-Yun, Li, Ning, Duan, James J.-W, Jiang, Bin, Lu, Zhonghui, Ngu, Khehyong, Tino, Joseph, Kopcho, Lisa M, Lu, Hao, Chen, Jing, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Yanchunas, Joseph, Calambur, Deepa, Gao, Mian, Shuster, David J, Susulic, Vojkan, Xie, Jenny H, Guarino, Victor R, Wu, Dauh-Rurng, Gregor, Kurt R, Goldstine, Christine B, Hynes, John, Macor, John E, Salter-Cid, Luisa, Burke, James R, Shaw, Patrick J, Dhar, T. G. Murali

“…Scaffold hopping and structure-based drug design were employed to identify substituted 4-aminoquinolines and 4-aminonaphthyridines as potent, small molecule…”
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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy by Marcoux, David, Duan, James J.-W, Shi, Qing, Cherney, Robert J, Srivastava, Anurag S, Cornelius, Lyndon, Batt, Douglas G, Liu, Qingjie, Beaudoin-Bertrand, Myra, Weigelt, Carolyn A, Khandelwal, Purnima, Vishwakrishnan, Sureshbabu, Selvakumar, Kumaravel, Karmakar, Ananta, Gupta, Arun Kumar, Basha, Mushkin, Ramlingam, Sridharan, Manjunath, Naveen, Vanteru, Sridhar, Karmakar, Sukhen, Maddala, Nageswara, Vetrichelvan, Muthalagu, Gupta, Anuradha, Rampulla, Richard A, Mathur, Arvind, Yip, Shiuhang, Li, Peng, Wu, Dauh-Rurng, Khan, Javed, Ruzanov, Max, Sack, John S, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Li, Sha, Shuster, David J, Borowski, Virna, Xie, Jenny H, McIntyre, Kim W, Obermeier, Mary T, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Hynes, John, Tino, Joseph A, Macor, John E, Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H, Dhar, T. G. Murali

“…RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been…”
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Teeth: Among Nature's Most Durable Biocomposites by Lawn, Brian R., Lee, James J.-W., Chai, Herzl

“…This paper addresses the durability of natural teeth from a materials perspective. Teeth are depicted as smart biocomposites, highly resistant to cumulative…”
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Vmeasur: A software package for experimental and clinical measurement of mesenteric lymphatic contractile function over an extended vessel length by Russell, Peter S., Hucklesby, James J. W., Hong, Jiwon, Cao, Enyuan, Trevaskis, Natalie L., Angel, Catherine E., Windsor, John A., Phillips, Anthony R. J.

“…Objective Conventionally, in vivo mesenteric lymphatic contractile function is measured using a high magnification transmission microscope (field of view…”
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On the interfacial fracture of porcelain/zirconia and graded zirconia dental structures by Chai, Herzl, Lee, James J.-W., Mieleszko, Adam J., Chu, Stephen J., Zhang, Yu

“…Low interfacial fracture energy of porcelain-veneered zirconia may lead to multiple channel cracking and veneer delamination (left). Utilizing a…”
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Fracture in teeth-a diagnostic for inferring bite force and tooth function by Lee, James J.-W., Constantino, Paul J., Lucas, Peter W., Lawn, Brian R.

“…Teeth are brittle and highly susceptible to cracking. We propose that observations of such cracking can be used as a diagnostic tool for predicting bite force…”
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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists by Duan, James J.-W, Lu, Zhonghui, Jiang, Bin, Stachura, Sylwia, Weigelt, Carolyn A, Sack, John S, Khan, Javed, Ruzanov, Max, Galella, Michael A, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Shuster, David J, Borowski, Virna, Xie, Jenny H, Zhang, Lisa, Vanteru, Sridhar, Gupta, Arun Kumar, Mathur, Arvind, Zhao, Qihong, Foster, William, Salter-Cid, Luisa M, Carter, Percy H, Dhar, T. G. Murali

“…A new phenyl (3-phenylpyrrolidin-3-yl)­sulfone series of RORγt inverse agonists was discovered utilizing the binding conformation of previously reported…”
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Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists by Jiang, Bin, Duan, James J.-W., Stachura, Sylwia, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Weigelt, Carolyn A., Khan, Javed, Sack, John S., Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Galella, Michael A., Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Dhar, T.G. Murali

“…[Display omitted] A novel series of cis-3,4-diphenylpyrrolidines were designed as RORγt inverse agonists based on the binding conformation of previously…”
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Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells by Anchan, Akshata, Martin, Olivia, Hucklesby, James J W, Finlay, Graeme, Johnson, Rebecca H, Robilliard, Laverne D, O'Carroll, Simon J, Angel, Catherine E, Graham, E Scott

“…We have recently demonstrated that invasive melanoma cells are capable of disrupting the brain endothelial barrier integrity. This was shown using ECIS…”
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Superresolved polarization-enhanced second-harmonic generation for direct imaging of nanoscale changes in collagen architecture by Johnson, Peter B, Karvounis, Artemios, Singh, H Johnson, Brereton, Christopher J, Bourdakos, Konstantinos N, Lunn, Kerry, Roberts, James J W, Davies, Donna E, Muskens, Otto L, Jones, Mark G, Mahajan, Sumeet

“…Superresolution (SR) optical microscopy has allowed the investigation of many biological structures below the diffraction limit; however, most of the…”
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Analysis of fracture and deformation modes in teeth subjected to occlusal loading by Lawn, Brian R., Lee, James J-W.

“…An analysis of fracture and deformation modes in tooth enamel subjected to occlusal loading is presented. Several competing modes are identified: deformation…”
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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists by Lu, Zhonghui, Duan, James J.-W., Xiao, Haiyun, Neels, James, Wu, Dauh-Rurng, Weigelt, Carolyn A., Sack, John S., Khan, Javed, Ruzanov, Max, An, Yongmi, Yarde, Melissa, Karmakar, Ananta, Vishwakrishnan, Sureshbabu, Baratam, Venkata, Shankarappa, Harisha, Vanteru, Sridhar, Babu, Venkatesh, Basha, Mushkin, Kumar Gupta, Arun, Kumaravel, Selvakumar, Mathur, Arvind, Zhao, Qihong, Salter-Cid, Luisa M., Carter, Percy H., Murali Dhar, T.G.

“…[Display omitted] An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that…”
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