Search Results - "James, H. F."

Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants by Alaa, Ahmed M, Bolton, Thomas, Di Angelantonio, Emanuele, Rudd, James H F, van der Schaar, Mihaela

“…Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone of preventative cardiology. Risk prediction models currently recommended by…”
Get full text

Alcohol use disorders and the heart by Day, Ed, Rudd, James H. F.

“…Alcohol use is an important preventable and modifiable cause of non‐communicable disease, and has complex effects on the cardiovascular system that vary with…”
Get full text

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial by Joshi, Nikhil V, Vesey, Alex T, Williams, Michelle C, Shah, Anoop S V, Calvert, Patrick A, Craighead, Felicity H M, Yeoh, Su Ern, Wallace, William, Salter, Donald, Fletcher, Alison M, van Beek, Edwin J R, Flapan, Andrew D, Uren, Neal G, Behan, Miles W H, Cruden, Nicholas L M, Mills, Nicholas L, Fox, Keith A A, Rudd, James H F, Dweck, Marc R, Newby, David E

“…The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and…”
Get full text

PET imaging of inflammation in atherosclerosis by Tarkin, Jason M., Joshi, Francis R., Rudd, James H. F.

“…Key Points 18 F-fluorodeoxyglucose (FDG) PET imaging of atherosclerosis is a reliable and reproducible measure of vascular inflammation, which can be used as a…”
Get full text

Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial by Fayad, Zahi A, Prof, Mani, Venkatesh, PhD, Woodward, Mark, Prof, Kallend, David, MB BS, Abt, Markus, PhD, Burgess, Tracy, MSc, Fuster, Valentin, Prof, Ballantyne, Christie M, Prof, Stein, Evan A, Prof, Tardif, Jean-Claude, Prof, Rudd, James H F, MD, Farkouh, Michael E, MD, Tawakol, Ahmed, MD

“…Summary Background Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein cholesterol (HDL-C). After the…”
Get full text

Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation: Results of a Multicenter Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Feasibility Study by TAWAKOL, Ahmed, FAYAD, Zahi A, NUNES, Irene O, BEALS, Chan R, SHANKAR, Sudha S, MOGG, Robin, ALON, Achilles, KLIMAS, Michael T, DANSKY, Hayes, SUBRAMANIAN, Sharath S, ABDELBAKY, Amr, RUDD, James H. F, FARKOUH, Michael E

“…The study sought to test whether high-dose statin treatment would result in greater reductions in plaque inflammation than low-dose statins, using…”
Get full text

Coronary Arterial 18F-Sodium Fluoride Uptake: A Novel Marker of Plaque Biology by DWECK, Marc R, CHOW, Marcus W. L, BOON, Nicholas A, RUDD, James H. F, NEWBY, David E, JOSHI, Nikhil V, WILLIAMS, Michelle C, JONES, Charlotte, FLETCHER, Alison M, RICHARDSON, Hamish, WHITE, Audrey, MCKILLOP, Graham, BEEK, Edwin J. R. Van

“…With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and…”
Get full text

Anti-Tumor Necrosis Factor-α Therapy Reduces Aortic Inflammation and Stiffness in Patients With Rheumatoid Arthritis by MÄKI-PETÄJÄ, Kaisa M, ELKHAWAD, Maysoon, CHERIYAN, Joseph, JOSHI, Francis R, ÖSTÖR, Andrew J. K, HALL, Frances C, RUDD, James H. F, WILKINSON, Ian B

“…Rheumatoid arthritis (RA) is a systemic inflammatory condition associated with increased cardiovascular risk. This is not fully explained by traditional risk…”
Get full text

Assessing robustness of carotid artery CT angiography radiomics in the identification of culprit lesions in cerebrovascular events by Le, Elizabeth P. V., Rundo, Leonardo, Tarkin, Jason M., Evans, Nicholas R., Chowdhury, Mohammed M., Coughlin, Patrick A., Pavey, Holly, Wall, Chris, Zaccagna, Fulvio, Gallagher, Ferdia A., Huang, Yuan, Sriranjan, Rouchelle, Le, Anthony, Weir-McCall, Jonathan R., Roberts, Michael, Gilbert, Fiona J., Warburton, Elizabeth A., Schönlieb, Carola-Bibiane, Sala, Evis, Rudd, James H. F.

“…Radiomics, quantitative feature extraction from radiological images, can improve disease diagnosis and prognostication. However, radiomic features are…”
Get full text

Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients With Aortic Stenosis by DWECK, Richard, JONES, Charlotte, SALTER, Donald M, MCKILLOP, Graham, VAN BEEK, Edwin J. R, BOON, Nicholas A, RUDD, James H. F, NEWBY, David E, JOSHI, Nikhil V, FLETCHER, Alison M, RICHARDSON, Hamish, WHITE, Audrey, MARSDEN, Mark, PESSOTTO, Renzo, CLARK, John C, WALLACE, William A

“…The pathophysiology of aortic stenosis is incompletely understood, and the relative contributions of valvular calcification and inflammation to disease…”
Get full text

High-Dose Atorvastatin Reduces Periodontal Inflammation: A Novel Pleiotropic Effect of Statins by SUBRAMANIAN, Sharath, EMAMI, Hamed, FAYAD, Zahi A, VAN DYKE, Thomas E, TAWAKOL, Ahmed, VUCIC, Esad, SINGH, Parmanand, VIJAYAKUMAR, Jayanthi, FIFER, Kenneth M, ALON, Achilles, SHANKAR, Sudha S, FARKOUH, Michael, RUDD, James H. F

“…The purpose of this study was to test whether high-dose statin treatment would result in a reduction in periodontal inflammation as assessed by…”
Get full text

Lower limb arterial calcification (LLAC) scores in patients with symptomatic peripheral arterial disease are associated with increased cardiac mortality and morbidity by Chowdhury, Mohammed M, Makris, Gregory C, Tarkin, Jason M, Joshi, Francis R, Hayes, Paul D, Rudd, James H F, Coughlin, Patrick A

“…The association of coronary arterial calcification with cardiovascular morbidity and mortality is well-recognized. Lower limb arterial calcification (LLAC) is…”
Get full text

Short-term changes in arterial inflammation predict long-term changes in atherosclerosis progression by Joseph, Philip, Ishai, Amorina, Mani, Venkatesh, Kallend, David, Rudd, James H. F., Fayad, Zahi A., Tawakol, Ahmed

“…Purpose It remains unclear whether changes in arterial wall inflammation are associated with subsequent changes in the rate of structural progression of…”
Get full text

Inflammation Imaging in Atherosclerosis by Rudd, James H.F, Hyafil, Fabien, Fayad, Zahi A

“…Inflammation is important at many stages of atherosclerotic plaque development. We highlight several imaging modalities that can quantify the degree of plaque…”
Get full text

Detection and Prediction of Bioprosthetic Aortic Valve Degeneration by Cartlidge, Timothy R.G., Doris, Mhairi K., Sellers, Stephanie L., Pawade, Tania A., White, Audrey C., Pessotto, Renzo, Kwiecinski, Jacek, Fletcher, Alison, Alcaide, Carlos, Lucatelli, Christophe, Densem, Cameron, Rudd, James H.F., van Beek, Edwin J.R., Tavares, Adriana, Virmani, Renu, Berman, Daniel, Leipsic, Jonathon A., Newby, David E., Dweck, Marc R.

“…Bioprosthetic aortic valve degeneration is increasingly common, often unheralded, and can have catastrophic consequences. The authors sought to assess whether…”
Get full text

PET imaging of the neurovascular interface in cerebrovascular disease by Evans, Nicholas R., Tarkin, Jason M., Buscombe, John R., Markus, Hugh S., Rudd, James H. F., Warburton, Elizabeth A.

“…Key Points PET enables noninvasive detection and quantification of inflammation, microcalcification and hypoxia, which are all associated with plaque rupture…”
Get full text

The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial by Fisk, Marie, Cheriyan, Joseph, Mohan, Divya, Forman, Julia, Mäki-Petäjä, Kaisa M, McEniery, Carmel M, Fuld, Jonathan, Rudd, James H F, Hopkinson, Nicholas S, Lomas, David A, Cockcroft, John R, Tal-Singer, Ruth, Polkey, Michael I, Wilkinson, Ian B

“…Cardiovascular disease is a major cause of morbidity and mortality in COPD patients. Systemic inflammation associated with COPD, is often hypothesised as a…”
Get full text

PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology by Evans, Nicholas R., Tarkin, Jason M., Chowdhury, Mohammed M., Warburton, Elizabeth A., Rudd, James H. F.

“…Atherosclerosis is a leading cause of morbidity and mortality. It is now widely recognized that the disease is more than simply a flow-limiting process and…”
Get full text

Atherosclerosis imaging using PET: Insights and applications by Sriranjan, Rouchelle S., Tarkin, Jason M., Evans, Nicholas R., Le, Elizabeth P.V., Chowdhury, Mohammed M., Rudd, James H.F.

“…PET imaging is able to harness biological processes to characterise high‐risk features of atherosclerotic plaque prone to rupture. Current radiotracers are…”
Get full text

18Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible : Implications for atherosclerosis therapy trials by RUDD, James H. F, MYERS, Kelly S, BANSILAL, Sameer, MACHAC, Josef, RAFIQUE, Ash, FARKOUH, Michael, FUSTER, Valentin, FAYAD, Zahi A

“…18Fluorodeoxyglucose Positron Emission Tomography Imaging of Atherosclerotic Plaque Inflammation Is Highly Reproducible: Implications for Atherosclerosis…”
Get full text