Search Results - "James, G M"

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study by Robert, Caroline, Prof, Ribas, Antoni, Prof, Schachter, Jacob, Prof, Arance, Ana, MD, Grob, Jean-Jacques, Prof, Mortier, Laurent, Prof, Daud, Adil, Prof, Carlino, Matteo S, MB, McNeil, Catriona M, MD, Lotem, Michal, Prof, Larkin, James M G, Prof, Lorigan, Paul, Prof, Neyns, Bart, Prof, Blank, Christian U, Prof, Petrella, Teresa M, MD, Hamid, Omid, MD, Su, Shu-Chih, PhD, Krepler, Clemens, MD, Ibrahim, Nageatte, MD, Long, Georgina V, Prof

“…SummaryBackgroundPembrolizumab improved progression-free survival and overall survival versus ipilimumab in patients with advanced melanoma and is now a…”
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Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma by Sarnaik, Amod A, Hamid, Omid, Khushalani, Nikhil I, Lewis, Karl D, Medina, Theresa, Kluger, Harriet M, Thomas, Sajeve S, Domingo-Musibay, Evidio, Pavlick, Anna C, Whitman, Eric D, Martin-Algarra, Salvador, Corrie, Pippa, Curti, Brendan D, Oláh, Judit, Lutzky, Jose, Weber, Jeffrey S, Larkin, James M G, Shi, Wen, Takamura, Toshimi, Jagasia, Madan, Qin, Harry, Wu, Xiao, Chartier, Cecile, Graf Finckenstein, Friedrich, Fardis, Maria, Kirkwood, John M, Chesney, Jason A

“…Effective treatment options are limited for patients with advanced (metastatic or unresectable) melanoma who progress after immune checkpoint inhibitors and…”
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Active surveillance in metastatic renal-cell carcinoma: a prospective, phase 2 trial by Rini, Brian I, Prof, Dorff, Tanya B, MD, Elson, Paul, ScD, Rodriguez, Cristina Suarez, MD, Shepard, Dale, MD, Wood, Laura, MSN, Humbert, Jordi, BSc, Pyle, Linda, RN, Wong, Yu-Ning, MD, Finke, James H, Prof, Rayman, Patricia A, MS, Larkin, James M G, FRCP, Garcia, Jorge A, MD, Plimack, Elizabeth R, MD

“…Summary Background A subset of patients with metastatic renal-cell carcinoma show indolent growth of metastases. Because of the toxicity and non-curative…”
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Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma by Kelderman, Sander, Heemskerk, Bianca, van Tinteren, Harm, van den Brom, Rob R. H., Hospers, Geke A. P., van den Eertwegh, Alfonsus J. M., Kapiteijn, Ellen W., de Groot, Jan Willem B., Soetekouw, Patricia, Jansen, Rob L., Fiets, Edward, Furness, Andrew J. S., Renn, Alexandra, Krzystanek, Marcin, Szallasi, Zoltan, Lorigan, Paul, Gore, Martin E., Schumacher, Ton N. M., Haanen, John B. A. G., Larkin, James M. G., Blank, Christian U.

“…Introduction Ipilimumab, a cytotoxic T lymphocyte-associated antigen-4 blocking antibody, has improved overall survival (OS) in metastatic melanoma in phase…”
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High Arctic plant community resists 15 years of experimental warming by Hudson, James M. G., Henry, Greg H. R.

“…1. Identifying plant communities that are resistant to climate change will be critical for developing accurate, wide-scale vegetation change predictions. Most…”
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Perceptual and neural consequences of rapid motion adaptation by Glasser, Davis M, Tsui, James M. G, Pack, Christopher C, Tadin, Duje

“…Nervous systems adapt to the prevailing sensory environment, and the consequences of this adaptation can be observed in the responses of single neurons and in…”
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Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma by Flaherty, Keith T, Robert, Caroline, Hersey, Peter, Nathan, Paul, Garbe, Claus, Milhem, Mohammed, Demidov, Lev V, Hassel, Jessica C, Rutkowski, Piotr, Mohr, Peter, Dummer, Reinhard, Trefzer, Uwe, Larkin, James M.G, Utikal, Jochen, Dreno, Brigitte, Nyakas, Marta, Middleton, Mark R, Becker, Jürgen C, Casey, Michelle, Sherman, Laurie J, Wu, Frank S, Ouellet, Daniele, Martin, Anne-Marie, Patel, Kiran, Schadendorf, Dirk

“…Treatment with trametinib, a MEK inhibitor, resulted in significantly improved progression-free and overall survival, as compared with chemotherapy, in…”
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Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity–impulsivity symptoms in ADHD measured with PET by Sigurdardottir, H. L., Kranz, G. S., Rami-Mark, C., James, G. M., Vanicek, T., Gryglewski, G., Berroterán-Infante, N., Kautzky, A., Hienert, M., Traub-Weidinger, T., Mitterhauser, M., Wadsak, W., Hartmann, A. M., Hacker, M., Rujescu, D., Kasper, S., Lanzenberger, R.

“…Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a robust genetic influence. The norepinephrine transporter (NET)…”
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The impact of AGN feedback and baryonic cooling on galaxy clusters as gravitational lenses by Mead, James M. G., King, Lindsay J., Sijacki, Debora, Leonard, Adrienne, Puchwein, Ewald, McCarthy, Ian G.

“…We investigate the impact of active galactic nucleus (AGN) feedback on the gravitational lensing properties of a sample of galaxy clusters with masses in the…”
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Implementing workplace-based assessment across the medical specialties in the United Kingdom by Wilkinson, James R, Crossley, James G M, Wragg, Andrew, Mills, Peter, Cowan, George, Wade, Winnie

“…Objectives  To evaluate the reliability and feasibility of assessing the performance of medical specialist registrars (SpRs) using three methods: the…”
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Pattern Motion Selectivity of Spiking Outputs and Local Field Potentials in Macaque Visual Cortex by Khawaja, Farhan A, Tsui, James M. G, Pack, Christopher C

“…The dorsal pathway of the primate visual cortex is involved in the processing of motion signals that are useful for perception and behavior. Along this…”
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Real-world outcomes with ipilimumab and nivolumab in advanced melanoma: a multicentre retrospective study by Serra-Bellver, Patricio, Versluis, Judith M., Oberoi, Honey K., Zhou, Cong, Slattery, Timothy D., Khan, Yasir, Patrinely, James R., Pires da Silva, Inês, Martínez-Vila, C., Cook, Natalie, Graham, Donna M., Carlino, Matteo S., Menzies, Alexander M., Arance, Ana M., Johnson, Douglas B., Long, Georgina V., Pickering, Lisa, Larkin, James M.G., Blank, Christian U., Lorigan, Paul

“…To assess efficacy and toxicity of combination immunotherapy with ipilimumab plus nivolumab in routine practice in a retrospective multicentre cohort of…”
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Contrast sensitivity of MT receptive field centers and surrounds by Tsui, James M G, Pack, Christopher C

“…Neurons throughout the visual system have receptive fields with both excitatory and suppressive components. The latter are responsible for a phenomenon known…”
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The mass-concentration relationship of virialized haloes and its impact on cosmological observables by King, Lindsay J., Mead, James M. G.

“…A generic property of the cuspy simulated virialized haloes in cold dark matter (CDM) cosmogenies is that their concentration is inversely correlated with…”
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Probing the cosmic web: intercluster filament detection using gravitational lensing by Mead, James M. G., King, Lindsay J., McCarthy, Ian G.

“…The problem of detecting dark matter filaments in the cosmic web is considered. Weak lensing is an ideal probe of dark matter, and therefore forms the basis of…”
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The role of V1 surround suppression in MT motion integration by Tsui, James M G, Hunter, J Nicholas, Born, Richard T, Pack, Christopher C

“…Neurons in the primate extrastriate cortex are highly selective for complex stimulus features such as faces, objects, and motion patterns. One explanation for…”
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Recent Progress toward Understanding Biosynthesis of the Amylopectin Crystal by Myers, Alan M., Morell, Matthew K., James, Martha G., Ball, Steven G.

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Recent advances in the treatment of renal cell carcinoma and the role of targeted therapies by Chowdhury, Simon, Larkin, James M.G, Gore, Martin E

“…Abstract Immunotherapy confers a small but significant overall survival advantage in metastatic renal cell carcinoma (RCC) but only for the minority of…”
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Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies by Eisen, T, Marais, R, Affolter, A, Lorigan, P, Robert, C, Corrie, P, Ottensmeier, C, Chevreau, C, Chao, D, Nathan, P D, Jouary, T, Harries, M, Negrier, S, Montegriffo, E, Ahmad, T, Gibbens, I, James, M G, Strauss, U P, Prendergast, S, Gore, M E

“…Method: The safety of oral sorafenib up to a maximum protocol-specified dose combined with dacarbazine in patients with metastatic, histologically confirmed…”
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A phase I II trial of sorafenib and infliximab in advanced renal cell carcinoma by Larkin, J M G, Ferguson, T R, Pickering, L M, Edmonds, K, James, M G, Thomas, K, Banerji, U, Berns, B, de Boer, C, Gore, M E

“…BACKGROUND: There is clinical evidence to suggest that tumour necrosis factor- α (TNF- α ) may be a therapeutic target in renal cell carcinoma (RCC)…”
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