Search Results - "James, E."
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Atmospheric Escape and the Evolution of Close-In Exoplanets
Published in Annual review of earth and planetary sciences (30-05-2019)“…Exoplanets with substantial hydrogen/helium atmospheres have been discovered in abundance, many residing extremely close to their parent stars. The extreme…”
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Oxidative Stress and Cancer
Published in Current pharmaceutical design (01-01-2018)“…Cancer is considered a major cause of death worldwide. The etiology of cancer is linked to environmental and genetic inheritance causes. Approximately 90…”
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Bistability, Bifurcations, and Waddington's Epigenetic Landscape
Published in Current biology (05-06-2012)“…Waddington's epigenetic landscape is probably the most famous and most powerful metaphor in developmental biology. Cells, represented by balls, roll downhill…”
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The Evaporation Valley in the Kepler Planets
Published in The Astrophysical journal (20-09-2017)“…A new piece of evidence supporting the photoevaporation-driven evolution model for low-mass, close-in exoplanets was recently presented by the…”
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The JAK-STAT Pathway at Twenty
Published in Immunity (Cambridge, Mass.) (20-04-2012)“…We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular…”
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Pyroptosis versus necroptosis: similarities, differences, and crosstalk
Published in Cell death and differentiation (01-01-2019)“…Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against…”
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Mechanisms of specificity in protein phosphorylation
Published in Nature reviews. Molecular cell biology (01-07-2007)“…A typical protein kinase must recognize between one and a few hundred bona fide phosphorylation sites in a background of approximately 700,000 potentially…”
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The Art of Changing the Brain: Enriching Teaching by Exploring the Biology of Learning
Published 2002“…Neuroscience tells us that the products of the mind-thought, emotions, artistic creation-are the result of the interactions of the biological brain with our…”
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Role of viral infections in the development and exacerbation of asthma in children
Published in Journal of allergy and clinical immunology (01-10-2017)“…Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory syncytial virus (RSV) is the main causative agent of…”
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Photoevaporation and high-eccentricity migration created the sub-Jovian desert
Published in Monthly notices of the Royal Astronomical Society (01-10-2018)Get full text
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Meta-analysis with Robust Variance Estimation: Expanding the Range of Working Models
Published in Prevention science (01-04-2022)“…In prevention science and related fields, large meta-analyses are common, and these analyses often involve dependent effect size estimates. Robust variance…”
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Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus
Published in Science (American Association for the Advancement of Science) (16-04-2010)“…The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows…”
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13
Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle
Published in Nature (London) (29-08-2013)“…In an in vitro Xenopus extract system that can undergo cell cycles, mitosis spreads through the cytoplasm in ‘trigger waves’ of Cdk1 activation, which may…”
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14
DNA Repair: The Search for Homology
Published in BioEssays (01-05-2018)“…The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the…”
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15
Constraining the entropy of formation from young transiting planet
Published in Monthly notices of the Royal Astronomical Society (01-11-2020)“…ABSTRACT Recently, K2 and TESS have discovered transiting planets with radii between ∼5 and 10 R⊕ around stars with ages <100 Myr. These young planets are…”
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16
Finerenone: First Approval
Published in Drugs (New York, N.Y.) (01-10-2021)“…Finerenone (Kerendia ® ), a first-in-class, orally administered, selective, nonsteroidal mineralocorticoid receptor antagonist (MRA), is being developed by…”
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Liposomal Irinotecan: A Review in Metastatic Pancreatic Adenocarcinoma
Published in Drugs (New York, N.Y.) (01-07-2020)“…Liposomal irinotecan (nal-IRI; Onivyde ® ; also known as pegylated liposomal irinotecan) has been developed with the aim of maximising anti-tumour efficacy…”
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18
Modeling the Cell Cycle: Why Do Certain Circuits Oscillate?
Published in Cell (18-03-2011)“…Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why…”
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Lymphatic System Flows
Published in Annual review of fluid mechanics (05-01-2018)“…The supply of oxygen and nutrients to tissues is performed by the blood system and involves a net leakage of fluid outward at the capillary level. One of the…”
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Drug delivery systems for RNA therapeutics
Published in Nature reviews. Genetics (01-05-2022)“…RNA-based gene therapy requires therapeutic RNA to function inside target cells without eliciting unwanted immune responses. RNA can be ferried into cells…”
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