Search Results - "James, Daylon"
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Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration
Published in Developmental cell (29-07-2013)“…Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but as yet unrecognized structural, phenotypic, and functional…”
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Reprogramming human endothelial cells to haematopoietic cells requires vascular induction
Published in Nature (London) (17-07-2014)“…Generating engraftable human haematopoietic cells from autologous tissues is a potential route to new therapies for blood diseases. However, directed…”
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Ovarian Reserve Disorders, Can We Prevent Them? A Review
Published in International journal of molecular sciences (06-12-2022)“…The ovarian reserve is finite and begins declining from its peak at mid-gestation until only residual follicles remain as women approach menopause. Reduced…”
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Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Published in Nature (London) (11-11-2010)“…During embryogenesis, endothelial cells induce organogenesis before the development of circulation. These findings suggest that endothelial cells not only form…”
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Engineered endothelium provides angiogenic and paracrine stimulus to grafted human ovarian tissue
Published in Scientific reports (15-08-2017)“…Despite major advances in tissue cryopreservation and auto-transplantation, reperfusion ischemia and hypoxia have been reported as major obstacles to…”
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Generation of functional multipotent adult stem cells from GPR125 + germline progenitors
Published in Nature (London) (20-09-2007)“…Adult mammalian testis is a source of pluripotent stem cells. However, the lack of specific surface markers has hampered identification and tracking of the…”
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Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice
Published in Angiogenesis (London) (01-08-2020)“…During the initiation of pregnancy, the vasculature of the implantation site expands rapidly, yet little is known about this process or its role in fertility…”
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Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells
Published in Blood (09-08-2012)“…Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy…”
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Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells
Published in Cell stem cell (06-03-2009)“…Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how regeneration of bone marrow vessels contributes to engraftment of…”
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Multivalent biomaterial platform to control the distinct arterial venous differentiation of pluripotent stem cells
Published in Biomaterials (01-12-2018)“…Vascular endothelial cells (ECs) differentiated from pluripotent stem cells have enormous potential to be used in a variety of therapeutic areas such as tissue…”
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Comparison of Human Antral Follicles of Xenograft versus Ovarian Origin Reveals Disparate Molecular Signatures
Published in Cell reports (Cambridge) (11-08-2020)“…The activation, growth, and maturation of oocytes to an ovulatory phase, termed folliculogenesis, is governed by the orchestrated activity of multiple…”
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Wnt inhibition promotes vascular specification of embryonic cardiac progenitors
Published in Development (Cambridge) (01-01-2018)“…Several studies have demonstrated a multiphasic role for Wnt signaling during embryonic cardiogenesis and developed protocols that enrich for cardiac…”
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Contribution of human embryonic stem cells to mouse blastocysts
Published in Developmental biology (01-07-2006)“…In addition to their potential for cell-based therapies in the treatment of disease and injury, the broad developmental capacity of human embryonic stem cells…”
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Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition
Published in Blood (31-01-2013)“…Several studies have demonstrated that hematopoietic cells originate from endothelium in early development; however, the phenotypic progression of progenitor…”
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Prominin 1/CD133 endothelium sustains growth of proneural glioma
Published in PloS one (25-04-2013)“…In glioblastoma high expression of the CD133 gene, also called Prominin1, is associated with poor prognosis. The PDGF-driven proneural group represents a…”
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Human theca arises from ovarian stroma and is comprised of three discrete subtypes
Published in Communications biology (04-01-2023)“…Theca cells serve multiple essential functions during the growth and maturation of ovarian follicles, providing structural, metabolic, and steroidogenic…”
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Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells
Published in APL bioengineering (01-09-2023)“…During embryonic development, endothelial cells (ECs) undergo vasculogenesis to form a primitive plexus and assemble into networks comprised of mural…”
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Notch hyper-activation drives trans-differentiation of hESC-derived endothelium
Published in Stem cell research (01-09-2016)“…During development, endothelial cells (EC) display tissue-specific attributes that are unique to each vascular bed, as well as generic signaling mechanisms…”
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Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold
Published in Tissue engineering. Part A (01-01-2010)“…Scaffold-guided vascular tissue engineering has been investigated as a means to generate functional and transplantable vascular tissue grafts that increase the…”
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Niche players: Spermatogonial progenitors marked by GPR125
Published in Cell cycle (Georgetown, Tex.) (15-01-2008)“…The undifferentiated spermatogonia of adult mouse testes are composed of both true stem cells and committed progenitors. It is unclear what normally prevents…”
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