Search Results - "James, Charlotte A."

T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness" by James, Charlotte A, Seshadri, Chetan

“…Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies…”
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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells by James, Charlotte A., Xu, Yuexin, Aguilar, Melissa S., Jing, Lichen, Layton, Erik D., Gilleron, Martine, Minnaard, Adriaan J., Scriba, Thomas J., Day, Cheryl L., Warren, Edus H., Koelle, David M., Seshadri, Chetan

“…T cells recognize mycobacterial glycolipid (mycolipid) antigens presented by CD1b molecules, but the role of CD4 and CD8 co-receptors in mycolipid recognition…”
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Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans by James, Charlotte A, Yu, Krystle K Q, Mayer-Blackwell, Koshlan, Fiore-Gartland, Andrew, Smith, Malisa T, Layton, Erik D, Johnson, John L, Hanekom, Willem A, Scriba, Thomas J, Seshadri, Chetan

“…bacille Calmette-Guérin (BCG) has been used for 100 years and prevents disseminated tuberculosis and death in young children. However, it shows only partial…”
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CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis by James, Charlotte A, Yu, Krystle K Q, Gilleron, Martine, Prandi, Jacques, Yedulla, Vijayendar R, Moleda, Zuzanna Z, Diamanti, Eleonora, Khan, Momin, Aggarwal, Varinder K, Reijneveld, Josephine F, Reinink, Peter, Lenz, Stefanie, Emerson, Ryan O, Scriba, Thomas J, Souter, Michael N T, Godfrey, Dale I, Pellicci, Daniel G, Moody, D Branch, Minnaard, Adriaan J, Seshadri, Chetan, Van Rhijn, Ildiko

“…Mycobacterial cell wall lipids bind the conserved CD1 family of antigen-presenting molecules and activate T cells via their T cell receptors (TCRs)…”
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Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates by Yu, Krystle K. Q., Wilburn, Damien B., Hackney, Joshua A., Darrah, Patricia A., Foulds, Kathryn E., James, Charlotte A., Smith, Malisa T., Jing, Lichen, Seder, Robert A., Roederer, Mario, Koelle, David M., Swanson, Willie J., Seshadri, Chetan

“…Invariant NKT (iNKT) cells in both humans and non-human primates are activated by the glycolipid antigen, α-galactosylceramide (α-GalCer). However, the extent…”
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Molecular and Cellular Mechanisms of Mycobacterial Glycolipid Recognition by Human T Cells by James, Charlotte A

“…Tuberculosis (TB) is of high global health importance and disproportionately affects individuals in resource-limited settings. A major challenge to reducing…”
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