Search Results - "James, Charles D."

Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment by Hashizume, Rintaro, Smirnov, Ivan, Liu, Sharon, Phillips, Joanna J., Hyer, Jeanette, McKnight, Tracy R., Wendland, Michael, Prados, Michael, Banerjee, Anu, Nicolaides, Theodore, Mueller, Sabine, James, Charles D., Gupta, Nalin

“…Diffuse intrinsic pontine gliomas arise almost exclusively in children, and despite advances in treatment, the majority of patients die within 2 years after…”
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Rescue and propagation of fully retargeted oncolytic measles viruses by Russell, Stephen J, Nakamura, Takafumi, Peng, Kah-Whye, Harvey, Mary, Greiner, Suzanne, Lorimer, Ian A J, James, Charles D

“…Live attenuated measles viruses of the Edmonston lineage (MV-Edm) have potent anti-tumor activity but are not entirely tumor-specific owing to widespread…”
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Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas by Lewis, Rebecca, Li, Yuping D, Hoffman, Lindsey, Hashizume, Rintaro, Gravohac, Gordan, Rice, Gavin, Wadhwani, Nitin R, Jie, Chunfa, Pundy, Tatiana, Mania-Farnell, Barbara, Mayanil, Chandra S, Soares, Marcelo B, Lei, Ting, James, Charles D, Foreman, Nicolas K, Tomita, Tadanori, Xi, Guifa

“…BACKGROUND: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments,…”
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First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus by Kapur, Anita, O'Connor-Semmes, Robin, Hussey, Elizabeth K, Dobbins, Robert L, Tao, Wenli, Hompesch, Marcus, Smith, Glenn A, Polli, Joseph W, James, Jr, Charles D, Mikoshiba, Imao, Nunez, Derek J

“…Remogliflozin etabonate (RE) is the prodrug of remogliflozin, a selective inhibitor of the renal sodium-dependent glucose transporter 2 (SGLT2), which could…”
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Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival by Zhai, Lijie, Ladomersky, Erik, Lauing, Kristen L, Wu, Meijing, Genet, Matthew, Gritsina, Galina, Győrffy, Balázs, Brastianos, Priscilla K, Binder, David C, Sosman, Jeffrey A, Giles, Francis J, James, Charles D, Horbinski, Craig, Stupp, Roger, Wainwright, Derek A

“…Indoleamine 2,3 dioxygenase 1 (IDO1) mediates potent immunosuppression in multiple preclinical models of cancer. However, the basis for elevated IDO1…”
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Immunocompetent murine models for the study of glioblastoma immunotherapy by Oh, Taemin, Fakurnejad, Shayan, Sayegh, Eli T, Clark, Aaron J, Ivan, Michael E, Sun, Matthew Z, Safaee, Michael, Bloch, Orin, James, Charles D, Parsa, Andrew T

“…Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are…”
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Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus by Hussey, Elizabeth K, Kapur, Anita, O'Connor-Semmes, Robin, Tao, Wenli, Rafferty, Bryan, Polli, Joseph W, James, Jr, Charles D, Dobbins, Robert L

“…The sodium-dependent glucose co-transporter-2 (SGLT2) is expressed in absorptive epithelia of the renal tubules. Remogliflozin etabonate (RE) is the prodrug of…”
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Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges by Vatner, Ralph, James, Charles D., Sathiaseelan, Vythialingam, Bondra, Kathryn M., Kalapurakal, John A., Houghton, Peter J.

“…Despite radiation therapy (RT) being an integral part of the treatment of most pediatric cancers and the recent discovery of novel molecular‐targeted agents…”
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A human brainstem glioma xenograft model enabled for bioluminescence imaging by Hashizume, Rintaro, Ozawa, Tomoko, Dinca, Eduard B., Banerjee, Anuradha, Prados, Michael D., James, Charles D., Gupta, Nalin

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TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas by Gonzalez-Buendia, Edgar, Zhao, Junfei, Wang, Lu, Mukherjee, Subhas, Zhang, Daniel, Arrieta, Víctor A, Feldstein, Eric, Kane, J Robert, Kang, Seong Jae, Lee-Chang, Catalina, Mahajan, Aayushi, Chen, Li, Realubit, Ronald, Karan, Charles, Magnuson, Lisa, Horbinski, Craig, Marshall, Stacy A, Sarkaria, Jann N, Mohyeldin, Ahmed, Nakano, Ichiro, Bansal, Mukesh, James, Charles D, Brat, Daniel J, Ahmed, Atique, Canoll, Peter, Rabadan, Raul, Shilatifard, Ali, Sonabend, Adam M

“…The epigenetic mechanisms involved in transcriptional regulation leading to malignant phenotype in gliomas remains poorly understood. Topoisomerase IIB…”
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The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma by Horbinski, Craig, Xi, Guifa, Wang, Yufen, Hashizume, Rintaro, Gopalakrishnan, Mahesh, Phillips, Joanna J, Houghton, Peter, James, Charles D, Kalapurakal, John A

“…Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas…”
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The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions by Tripathi, Shashwat, Nathan, Cody L, Tate, Matthew C, Horbinski, Craig M, Templer, Jessica W, Rosenow, Joshua M, Sita, Timothy L, James, Charles D, Deneen, Benjamin, Miller, Stephen D, Heimberger, Amy B

“…Epilepsy has a profound impact on quality of life. Despite the development of new antiseizure medications (ASMs), approximately one-third of affected patients…”
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P53 in nonneoplastic central nervous system lesions: An immunohistochemical and genetic sequencing study by KURTKAYA-YAPICIER, Özlem, SCHEITHAUER, Bernd W, HEBRINK, Deanne, JAMES, Charles D, GLICK, Roberta P, LICHTOR, Terry, HODGE, Charles J, RUTKA, James T, PIEPMEIER, Joseph M

“…Immunostaining for p53 commonly is considered a marker of neoplasia. Previous studies of nonneoplastic processes have yielded conflicting results. To test the…”
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A human brainstem glioma xenograft model enabled for bioluminescence imaging by Hashizume, Rintaro, Ozawa, Tomoko, Dinca, Eduard B., Banerjee, Anuradha, Prados, Michael D., James, Charles D., Gupta, Nalin

“…Despite the use of radiation and chemotherapy, the prognosis for children with diffuse brainstem gliomas is extremely poor. There is a need for relevant…”
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Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells by Clark, Aaron J, Safaee, Michael, Oh, Taemin, Ivan, Michael E, Parimi, Vamsi, Hashizume, Rintaro, Ozawa, Tomoko, James, Charles D, Bloch, Orin, Parsa, Andrew T

“…GL261 cells are murine glioma cells that demonstrate proliferation, invasion, and angiogenesis when implanted in syngeneic C57BL/6 mice, providing a highly…”
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Convection-enhanced delivery of targeted quantum dot-immunoliposome hybrid nanoparticles to intracranial brain tumor models by Weng, Kevin C, Hashizume, Rintaro, Noble, Charles O, Serwer, Laura P, Drummond, Daryl C, Kirpotin, Dmitri B, Kuwabara, Anne M, Chao, Lucy X, Chen, Fanqing F, James, Charles D, Park, John W

“…The aim of this work is to evaluate combining targeting strategy and convection-enhanced delivery in brain tumor models by imaging quantum dot-immunoliposome…”
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Chromosome anomalies detected by interphase fluorescence in situ hybridization: correlation with significant biological features of B‐cell chronic lymphocytic leukaemia by Dewald, Gordon W., Brockman, Stephanie R., Paternoster, Sarah F., Bone, Nancy D., O'Fallon, Judith R., Allmer, Cristine, James, Charles D., Jelinek, Diane F., Tschumper, Renee C., Hanson, Curtis A., Pruthi, Rajiv K., Witzig, Thomas E., Call, Timothy G., Kay, Neil E.

“…Fluorescence in situ hybridization (FISH) was used to detect 6q–, 11q–, +12, 13q–, 17p– and translocations involving 14q32 in interphase nuclei from blood…”
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Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma by GIANNINI, Caterina, HEBRINK, Deanne, SCHEITHAUER, Bernd W, DEI TOS, Angelo P, JAMES, Charles D

“…Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially situated tumor that most frequently occurs in the temporal lobe of young adults and is often…”
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Abstract 1345: Mutant IDH1 and tissue factor in gliomas by Unruh, Dusten, Mirkov, Snezana, James, Charles D., Horbinski, Craig

“…Abstract Background: IDH1 mutations (IDH1mut) occur in 20-30% of gliomas, induce DNA hypermethylation, and are associated with a better prognosis than IDH1…”
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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