Search Results - "James, C David"

Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations by Zhang, Daniel Y, Dmello, Crismita, Chen, Li, Arrieta, Victor A, Gonzalez-Buendia, Edgar, Kane, J Robert, Magnusson, Lisa P, Baran, Aneta, James, C David, Horbinski, Craig, Carpentier, Alexandre, Desseaux, Carole, Canney, Michael, Muzzio, Miguel, Stupp, Roger, Sonabend, Adam M

“…Paclitaxel shows little benefit in the treatment of glioma due to poor penetration across the blood-brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU)…”
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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression by Chan, Kui-Ming, Fang, Dong, Gan, Haiyun, Hashizume, Rintaro, Yu, Chuanhe, Schroeder, Mark, Gupta, Nalin, Mueller, Sabine, James, C David, Jenkins, Robert, Sarkaria, Jann, Zhang, Zhiguo

“…Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of…”
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IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma by Ladomersky, Erik, Zhai, Lijie, Lenzen, Alicia, Lauing, Kristen L, Qian, Jun, Scholtens, Denise M, Gritsina, Galina, Sun, Xuebing, Liu, Ye, Yu, Fenglong, Gong, Wenfeng, Liu, Yong, Jiang, Beibei, Tang, Tristin, Patel, Ricky, Platanias, Leonidas C, James, C David, Stupp, Roger, Lukas, Rimas V, Binder, David C, Wainwright, Derek A

“…Glioblastoma is the most aggressive primary brain tumor in adults with a median survival of 15-20 months. Numerous approaches and novel therapeutics for…”
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Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model by Lee, Gina, Auffinger, Brenda, Guo, Donna, Hasan, Tanwir, Deheeger, Marc, Tobias, Alex L, Kim, Jeong Yeon, Atashi, Fatemeh, Zhang, Lingjiao, Lesniak, Maciej S, James, C David, Ahmed, Atique U

“…Increasing evidence exposes a subpopulation of cancer cells, known as cancer stem cells (CSCs), to be critical for the progression of several human…”
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SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes by Song, Xiao, Wan, Xuechao, Huang, Tianzhi, Zeng, Chang, Sastry, Namratha, Wu, Bingli, James, C David, Horbinski, Craig, Nakano, Ichiro, Zhang, Wei, Hu, Bo, Cheng, Shi-Yuan

“…Misregulated alternative RNA splicing (AS) contributes to the tumorigenesis and progression of human cancers, including glioblastoma (GBM). Here, we showed…”
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma by Hashizume, Rintaro, Andor, Noemi, Ihara, Yuichiro, Lerner, Robin, Gan, Haiyun, Chen, Xiaoyue, Fang, Dong, Huang, Xi, Tom, Maxwell W, Ngo, Vy, Solomon, David, Mueller, Sabine, Paris, Pamela L, Zhang, Zhiguo, Petritsch, Claudia, Gupta, Nalin, Waldman, Todd A, James, C David

“…Hashizume et al . report a new therapeutic strategy for treating pediatric gliomas with mutations in the H3F3A gene by inhibiting histone demethylation…”
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CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation by Grainger, Rhian K., James, David C.

“…ABSTRACT Here we demonstrate that it is possible to predict and control N‐glycan processing of a secreted recombinant monoclonal antibody during manufacturing…”
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Glioblastoma-Derived IL6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth by Lamano, Jonathan B, Lamano, Jason Balquidera, Li, Yuping D, DiDomenico, Joseph D, Choy, Winward, Veliceasa, Dorina, Oyon, Daniel E, Fakurnejad, Shayan, Ampie, Leonel, Kesavabhotla, Kartik, Kaur, Rajwant, Kaur, Gurvinder, Biyashev, Dauren, Unruh, Dusten J, Horbinski, Craig M, James, C David, Parsa, Andrew T, Bloch, Orin

“…Upregulation of programmed death-ligand 1 (PD-L1) on circulating and tumor-infiltrating myeloid cells is a critical component of GBM-mediated immunosuppression…”
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Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations by Serwer, Laura P., James, C. David

“…The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics…”
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Activation of Dopamine Receptor 2 Prompts Transcriptomic and Metabolic Plasticity in Glioblastoma by Caragher, Seamus P, Shireman, Jack M, Huang, Mei, Miska, Jason, Atashi, Fatemeh, Baisiwala, Shivani, Hong Park, Cheol, Saathoff, Miranda R, Warnke, Louisa, Xiao, Ting, Lesniak, Maciej S, James, C David, Meltzer, Herbert, Tryba, Andrew K, Ahmed, Atique U

“…Glioblastoma (GBM) is one of the most aggressive and lethal tumor types. Evidence continues to accrue indicating that the complex relationship between GBM and…”
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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA by Nathanson, David A., Gini, Beatrice, Mottahedeh, Jack, Visnyei, Koppany, Koga, Tomoyuki, Gomez, German, Estin, Ascia, Hwang, Kiwook, Wang, Jun, Masui, Kenta, Paucar, Andres, Yang, Huijun, Ohashi, Minori, Zhu, Shaojun, Wykosky, Jill, Reed, Rachel, Nelson, Stanley F., Cloughesy, Timothy F., James, C. David, Rao, P. Nagesh, Kornblum, Harley I., Heath, James R., Cavenee, Webster K., Furnari, Frank B., Mischel, Paul S.

“…Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived…”
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miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma by Kouri, Fotini M, Hurley, Lisa A, Daniel, Weston L, Day, Emily S, Hua, Youjia, Hao, Liangliang, Peng, Chian-Yu, Merkel, Timothy J, Queisser, Markus A, Ritner, Carissa, Zhang, Hailei, James, C David, Sznajder, Jacob I, Chin, Lynda, Giljohann, David A, Kessler, John A, Peter, Marcus E, Mirkin, Chad A, Stegh, Alexander H

“…Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of numerous tumor cell subpopulations, including stem-like…”
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A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies by Kim, Minsoo, O'Callaghan, Peter M., Droms, Kurt A., James, David C.

“…One of the most significant problems in industrial bioprocessing of recombinant proteins using engineered mammalian cells is the phenomenon of cell line…”
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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 by Verhaak, Roel G.W., Hoadley, Katherine A., Purdom, Elizabeth, Wang, Victoria, Qi, Yuan, Wilkerson, Matthew D., Miller, C. Ryan, Ding, Li, Golub, Todd, Mesirov, Jill P., Alexe, Gabriele, Lawrence, Michael, O'Kelly, Michael, Tamayo, Pablo, Weir, Barbara A., Gabriel, Stacey, Winckler, Wendy, Gupta, Supriya, Jakkula, Lakshmi, Feiler, Heidi S., Hodgson, J. Graeme, James, C. David, Sarkaria, Jann N., Brennan, Cameron, Kahn, Ari, Spellman, Paul T., Wilson, Richard K., Speed, Terence P., Gray, Joe W., Meyerson, Matthew, Getz, Gad, Perou, Charles M., Hayes, D. Neil

“…The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based…”
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Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas by Engler, Jane R, Robinson, Aaron E, Smirnov, Ivan, Hodgson, J Graeme, Berger, Mitchel S, Gupta, Nalin, James, C David, Molinaro, Annette, Phillips, Joanna J

“…Glioblastoma (GBM) is a highly malignant brain tumor with a dismal prognosis. Gene expression profiling of GBM has revealed clinically relevant tumor subtypes,…”
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Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis by Krenzlin, Harald, Behera, Prajna, Lorenz, Viola, Passaro, Carmela, Zdioruk, Mykola, Nowicki, Michal O, Grauwet, Korneel, Zhang, Hong, Skubal, Magdalena, Ito, Hirotaka, Zane, Rachel, Gutknecht, Michael, Griessl, Marion B, Ricklefs, Franz, Ding, Lai, Peled, Sharon, Rooj, Arun, James, C David, Cobbs, Charles S, Cook, Charles H, Chiocca, E Antonio, Lawler, Sean E

“…Cytomegalovirus (CMV) has been implicated in glioblastoma (GBM); however, a mechanistic connection in vivo has not been established. The purpose of this study…”
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miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells by Silber, Joachim, Lim, Daniel A, Petritsch, Claudia, Persson, Anders I, Maunakea, Alika K, Yu, Mamie, Vandenberg, Scott R, Ginzinger, David G, James, C David, Costello, Joseph F, Bergers, Gabriele, Weiss, William A, Alvarez-Buylla, Arturo, Hodgson, J Graeme

“…Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights…”
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Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts by Michaud, Karine, Solomon, David A, Oermann, Eric, Kim, Jung-Sik, Zhong, Wei-Zhu, Prados, Michael D, Ozawa, Tomoko, James, C David, Waldman, Todd

“…Activation of cyclin-dependent kinases 4 and 6 (cdk4/6) occurs in the majority of glioblastoma multiforme (GBM) tumors, and represents a promising molecular…”
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Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma by Hasan, Tanwir, Caragher, Seamus P., Shireman, Jack M., Park, Cheol H., Atashi, Fatemeh, Baisiwala, Shivani, Lee, Gina, Guo, Donna, Wang, Jennifer Y., Dey, Mahua, Wu, Meijing, Lesniak, Maciej S., Horbinski, Craig M., James, C. David, Ahmed, Atique U.

“…Emerging evidence reveals enrichment of glioma-initiating cells (GICs) following therapeutic intervention. One factor known to contribute to this enrichment is…”
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