Search Results - "James, Andrew F."

Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome by Cheng, Hongwei, Charles, Ian, James, Andrew F, Abdala, Ana P, Hancox, Jules C

“…Rett syndrome (RTT) is a severe developmental disorder that is strongly linked to mutations in the gene. RTT has been associated with sudden unexplained death…”
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Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular I Ca density in mouse ventricular myocytes by Bryant, Simon M, Kong, Cherrie H T, Watson, Judy J, Gadeberg, Hanne C, Roth, David M, Patel, Hemal H, Cannell, Mark B, James, Andrew F, Orchard, Clive H

“…Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and…”
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Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload by Zhang, Haifei, Cannell, Mark B, Kim, Shang Jin, Watson, Judy J, Norman, Ruth, Calaghan, Sarah C, Orchard, Clive H, James, Andrew F

“…Atrial remodeling due to elevated arterial pressure predisposes the heart to atrial fibrillation (AF). Although abnormal sarcoplasmic reticulum (SR) function…”
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Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes by Hancock, Jane M., PhD, Weatherall, Kate L., PhD, Choisy, Stéphanie C., PhD, James, Andrew F., DPhil, Hancox, Jules C., PhD, Marrion, Neil V., PhD

“…Background Activation of small conductance calcium-activated potassium (SK) channels is proposed to contribute to repolarization of the action potential in…”
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Heterogeneity of T-Tubules in Pig Hearts by Gadeberg, Hanne C, Bond, Richard C, Kong, Cherrie H T, Chanoit, Guillaume P, Ascione, Raimondo, Cannell, Mark B, James, Andrew F

“…T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were…”
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Modulation of Spontaneous Action Potential Rate by Inositol Trisphosphate in Myocytes from the Rabbit Atrioventricular Node by Cheng, Hongwei, Kong, Cherrie H T, James, Andrew F, Cannell, Mark B, Hancox, Jules C

“…The atrioventricular node (AVN) is a key component of the cardiac conduction system and takes over pacemaking of the ventricles if the sinoatrial node fails…”
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QTc interval and ventricular action potential prolongation in the Mecp2Null/+ murine model of Rett syndrome by Cheng, Hongwei, Charles, Ian, James, Andrew F., Abdala, Ana P., Hancox, Jules C.

“…Rett Syndrome (RTT) is a congenital, X‐chromosome‐linked developmental disorder characterized by developmental delay, dysautonomia, and breathing…”
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Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine by Caves, Rachel E., PhD, Cheng, Hongwei, PhD, Choisy, Stéphanie C., PhD, Gadeberg, Hanne C., PhD, Bryant, Simon M., PhD, Hancox, Jules C., PhD, James, Andrew F., DPhil

“…Abstract Background Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a…”
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Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart by Choisy, Stéphanie C, Cheng, Hongwei, Smith, Godfrey L, James, Andrew F, Hancox, Jules C

“…The atrioventricular node (AVN) is a key component of the cardiac pacemaker-conduction system. Although it is known that receptors for the peptide hormone…”
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Characterization and influence of cardiac background sodium current in the atrioventricular node by Cheng, Hongwei, Li, Jue, James, Andrew F, Inada, Shin, Choisy, Stéphanie C.M, Orchard, Clive H, Zhang, Henggui, Boyett, Mark R, Hancox, Jules C

“…Abstract Background inward sodium current (IB,Na ) that influences cardiac pacemaking has been comparatively under-investigated. The aim of this study was to…”
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COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2 by Carpenter, Alexander, Chambers, Owen J, El Harchi, Aziza, Bond, Richard, Hanington, Oliver, Harmer, Stephen C, Hancox, Jules C, James, Andrew F

“…The COVID-19 pandemic is an unprecedented challenge and will require novel therapeutic strategies. Affected patients are likely to be at risk of arrhythmia due…”
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Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts by Choisy, Stéphanie C.M, Arberry, Lesley A, Hancox, Jules C, James, Andrew F

“…Although hypertension is the most prevalent risk factor for atrial fibrillation, there is currently no information available from animal models of hypertension…”
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Enigmatic variations: The many facets of CFTR function in the heart by James, Andrew F.

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Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes by Bond, Richard C., Choisy, Stéphanie C., Bryant, Simon M., Hancox, Jules C., James, Andrew F.

“…The electrophysiological properties of pulmonary vein (PV)‐cardiomyocytes, and their responses to the sympathetic neurotransmitter, noradrenaline (NA), are…”
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Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel by Hancox, Jules C, James, Andrew F

“…hERG (human ether-à-go-go-related gene) potassium (K(+)) channels play a crucial role in electrophysiological activity in the heart, exerting a profound…”
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Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes by Caves, Rachel E., Carpenter, Alexander, Choisy, Stéphanie C., Clennell, Ben, Cheng, Hongwei, McNiff, Cameron, Mann, Brendan, Milnes, James T., Hancox, Jules C., James, Andrew F.

“…Atrial-ventricular differences in voltage-gated Na+ currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial…”
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Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts by Bryant, Simon M, Kong, Cherrie H.T, Watson, Judy, Cannell, Mark B, James, Andrew F, Orchard, Clive H

“…Abstract In mammalian cardiac ventricular myocytes, Ca influx and release occur predominantly at t-tubules, ensuring synchronous Ca release throughout the…”
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Comment: postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2 by Hancox, Jules C, James, Andrew F

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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome by Cheng, Hongwei, Du, Chunyun, Zhang, Yihong, James, Andrew F., Dempsey, Christopher E., Abdala, Ana P., Hancox, Jules C.

“…Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder associated with respiratory abnormalities and, in up to ~40% of patients, with prolongation of…”
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Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study by Shamsaldeen, Yousif A., Culliford, Lucy, Clout, Madeleine, James, Andrew F., Ascione, Raimondo, Hancox, Jules C., Marrion, Neil V.

“…Inhibition of SK channel function is being pursued in animal models as a possible therapeutic approach to treat atrial fibrillation (AF). However, the…”
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