Search Results - "James, Andrew D."

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor by Pawson, Tony, Bisson, Nicolas, James, D Andrew, Ivosev, Gordana, Tate, Stephen A, Bonner, Ron, Taylor, Lorne

“…Signaling pathways are commonly organized through inducible protein-protein interactions, mediated by adaptor proteins that link activated receptors to…”
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Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin by Zhu, Shaolong, Liuni, Peter, Ettorre, Luciano, Chen, Tricia, Szeto, Jason, Carpick, Bruce, James, D. Andrew, Wilson, Derek J

“…The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral…”
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Public opinion on megaprojects over time: findings from four megaprojects in the UK by Kundu, Oishee, James, Andrew D., Rigby, John

“…Megaprojects, due to their size, scale, and technical complexity are expensive and controversial, and how they proceed over time is a key topic of interest…”
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Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps by Bruce, Jason I. E., Sánchez-Alvarez, Rosa, Sans, Maria Dolors, Sugden, Sarah A., Qi, Nathan, James, Andrew D., Williams, John A.

“…Acute pancreatitis (AP) is serious inflammatory disease of the pancreas. Accumulating evidence links diabetes with severity of AP, suggesting that endogenous…”
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Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2) by James, Andrew D., Richardson, Daniel A., Oh, In-Whan, Sritangos, Pishyaporn, Attard, Thomas, Barrett, Lisa, Bruce, Jason I. E.

“…Background Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels…”
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Immunocartography: Charting vaccine-driven immunity by applying single cell proteomics to an in vitro human model by Duprez, Jessica S., Cohen, Michael, Li, Stephen, Wilson, Derek, Brookes, Roger H., James, D. Andrew

“…The ability to measure immunomodulatory effects of a vaccine is crucial for novel vaccine design. While traditional animal models have been effective, a better…”
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Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2 by Bruch, Eduardo M., Zhu, Shaolong, Szymkowicz, Lisa, Blake, Taylor, Kiss, Tara, James, D. Andrew, Rak, Alexey, Narayan, Kartik, Balmer, Matthew T., Chicz, Roman M.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, uses a surface expressed trimeric spike glycoprotein for…”
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Epitope screening using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An accelerated workflow for evaluation of lead monoclonal antibodies by Zhu, Shaolong, Liuni, Peter, Chen, Tricia, Houy, Camille, Wilson, Derek J., James, D. Andrew

“…Background Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and…”
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Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi by Chen, Chen, Jin, Jing, James, D. Andrew, Adams-Cioaba, Melanie A, Park, Jin Gyoon, Guo, Yahong, Tenaglia, Enrico, Xu, Chao, Gish, Gerald, Min, Jinrong, Pawson, Tony

“…Tudor domains are protein modules that mediate protein-protein interactions, potentially by binding to methylated ligands. A group of germline specific single…”
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Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo by Simon, Anna, Yang, Ming, Marrison, Joanne L, James, Andrew D, Hunt, Mark J, O'Toole, Peter J, Kaye, Paul M, Whittington, Miles A, Chawla, Sangeeta, Brackenbury, William J

“…An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can…”
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Formulation development of a stable influenza recombinant neuraminidase vaccine candidate by Li, Bing, Ustyugova, Irina V, Szymkowicz, Lisa, Zhu, Shaolong, Ming, Marin, Fung, Karen Y Y, Cortés, Guadalupe, James, D Andrew, Hrynyk, Michael, Rahman, Nausheen, Brookes, Roger H, Ausar, Salvador F

“…Current influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy…”
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Sodium regulates PLC and IP3R‐mediated calcium signaling in invasive breast cancer cells by James, Andrew D., Unthank, Katherine P., Jones, Isobel, Sajjaboontawee, Nattanan, Sizer, Rebecca E., Chawla, Sangeeta, Evans, Gareth J. O., Brackenbury, William J.

“…Intracellular Ca2+ signaling and Na+ homeostasis are inextricably linked via ion channels and co‐transporters, with alterations in the concentration of one ion…”
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The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP by James, Andrew D., Patel, Waseema, Butt, Zohra, Adiamah, Magretta, Dakhel, Raga, Latif, Ayse, Uggenti, Carolina, Swanton, Eileithyia, Imamura, Hiromi, Siriwardena, Ajith K., Bruce, Jason I.E.

“…Evidence suggests that the plasma membrane Ca2+-ATPase (PMCA), which is critical for maintaining a low intracellular Ca2+ concentration ([Ca2+]i), utilizes…”
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Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines by Szymkowicz, Lisa, Gerard, Jeffery, Messham, Benjamin, Tam, Wai Wan Vivian, James, D Andrew

“…The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from bacterial fermentation. As such, there are…”
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Eukaryotic protein domains as functional units of cellular evolution by Jin, Jing, Xie, Xueying, Chen, Chen, Park, Jin Gyoon, Stark, Chris, James, D Andrew, Olhovsky, Marina, Linding, Rune, Mao, Yongyi, Pawson, Tony

“…Modular protein domains are functional units that can be modified through the acquisition of new intrinsic activities or by the formation of novel domain…”
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Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity by Ausar, Salvador F., Zhu, Shaolong, Duprez, Jessica, Cohen, Michael, Bertrand, Thomas, Steier, Valérie, Wilson, Derek J., Li, Stephen, Sheung, Anthony, Brookes, Roger H., Pedyczak, Artur, Rak, Alexey, Andrew James, D.

“…The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of…”
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Glycolytic ATP Fuels the Plasma Membrane Calcium Pump Critical for Pancreatic Cancer Cell Survival by James, Andrew D., Chan, Anthony, Erice, Oihane, Siriwardena, Ajith K., Bruce, Jason I.E.

“…Pancreatic cancer is an aggressive cancer with poor prognosis and limited treatment options. Cancer cells rapidly proliferate and are resistant to cell death…”
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Understanding the emergence of new science and technology policies: Policy entrepreneurship, agenda setting and the development of the European Framework Programme by Edler, Jakob, James, Andrew D.

“…•Analyses process of STI policy making using example of security research in the EU Framework Programme.•Uses political science approaches to understand role…”
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Public procurement and innovation: a systematic literature review by Kundu, Oishee, James, Andrew D, Rigby, John

“…Abstract Public procurement and innovation is the subject of a growing body of literature. This article systematically reviews the existing research,…”
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Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization “Hotspots” in the SARS-CoV‑2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction by Narang, Dominic, James, D. Andrew, Balmer, Matthew T, Wilson, Derek J

“…The novel severe respiratory syndrome-like coronavirus (SARS-CoV-2) causes COVID-19 in humans and is responsible for one of the most destructive pandemics of…”
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