Search Results - "Jamburuthugoda, Varuni K."

Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules by Martinez-Vaz, Betsy M, Howard, Alicia L, Jamburuthugoda, Varuni K, Callahan, Kevin P

“…Cellular metabolism comprises a complex network of biochemical anabolic and catabolic processes that fuel the growth and survival of living organisms. The…”
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Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase by Jamburuthugoda, Varuni K, Eickbush, Thomas H

“…R2 non-LTR retrotransposons insert at a specific site in the 28S rRNA genes of many animal phyla. R2 elements encode a single polypeptide with reverse…”
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Macrophage Tropism of HIV-1 Depends on Efficient Cellular dNTP Utilization by Reverse Transcriptase by Diamond, Tracy L., Roshal, Mikhail, Jamburuthugoda, Varuni K., Reynolds, Holly M., Merriam, Aaron R., Lee, Kwi Y., Balakrishnan, Mini, Bambara, Robert A., Planelles, Vicente, Dewhurst, Stephen, Kim, Baek

“…Retroviruses utilize cellular dNTPs to perform proviral DNA synthesis in infected host cells. Unlike oncoretroviruses, which replicate in dividing cells,…”
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An Undergraduate Laboratory Exploring Mutational Mechanisms in Escherichia coli Based on the Luria-Delbrück Experiment by Hutchison, Elizabeth A., Scheffler, Abigail, Militello, Kevin T., Reinhardt, Josephine, Nedelkovska, Hristina, Jamburuthugoda, Varuni K.

“…Understanding the mechanism for DNA mutations is a key concept in most genetics and microbiology courses. In addition, understanding that most mutations occur…”
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Modification of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Target Cells with Elevated Cellular dNTP Concentrations by Jamburuthugoda, Varuni K., Chugh, Pauline, Kim, Baek

“…Retroviruses and DNA viruses utilize cellular dNTPs as substrates for their DNA polymerases during viral replication in infected cells. However, because of S…”
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Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage by Jamburuthugoda, Varuni K, Santos-Velazquez, Jose M., Skasko, Mark, Operario, Darwin J., Purohit, Vandana, Chugh, Pauline, Szymanski, Erika A., Wedekind, Joseph E., Bambara, Robert A., Kim, Baek

“…We characterized HIV-1 reverse transcriptase (RT) variants either with or without the (-)-2′,3′-deoxy-3′-thiacytidine-resistant M184I mutation isolated from a…”
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The diversity of retrotransposons and the properties of their reverse transcriptases by Eickbush, Thomas H., Jamburuthugoda, Varuni K.

“…A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Four major…”
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The Reverse Transcriptase Encoded by the Non-LTR Retrotransposon R2 Is as Error-Prone as That Encoded by HIV-1 by Jamburuthugoda, Varuni K., Eickbush, Thomas H.

“…Reverse transcriptases (RTs) encoded by a wide range of mobile retroelements have had a major impact on the structure and function of genomes. Among the most…”
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DNA-directed DNA Polymerase and Strand Displacement Activity of the Reverse Transcriptase Encoded by the R2 Retrotransposon by Kurzynska-Kokorniak, Anna, Jamburuthugoda, Varuni K., Bibillo, Arkadiusz, Eickbush, Thomas H.

“…R2 elements are non-long terminal repeat (non-LTR) retrotransposons with a single open reading-frame encoding reverse transcriptase, DNA endonuclease and…”
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Kinetic Evidence for Interaction of Human Immunodeficiency Virus Type 1 Reverse Transcriptase with the 3‘-OH of the Incoming dTTP Substrate by Jamburuthugoda, Varuni K, Guo, Dongdong, Wedekind, Joseph E, Kim, Baek

“…Two previously identified human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants, Q151N and V148I, are known to have reduced dNTP…”
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Macrophage tropism of HIV-1 depends upon efficient cellular dNTP utilization by reverse transcriptase by Diamond, Tracy L., Roshal, Mikhail, Jamburuthugoda, Varuni K., Reynolds, Holly M., Merriam, Aaron R., Lee, Kwi Y., Balakrishnan, Mini, Bambara, Robert A., Planelles, Vicente, Dewhurst, Stephen, Kim, Baek

“…Retroviruses utilize cellular dNTPs to perform proviral DNA synthesis in infected host cells. Unlike oncoretroviruses, which replicate only in dividing cells,…”
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dNTP interaction mechanisms of HIV -1 reverse transcriptase and viral cell type specific replication by Jamburuthugoda, Varuni K

“…Human Immunodeficiency Virus Type 1 (HIV-1) reverse transcriptase (RT) has been extensively studied due to its essential role in proviral synthesis and as an…”
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