Search Results - "Jambo, Kondwani C."

Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung by Pisu, Davide, Huang, Lu, Narang, Vipin, Theriault, Monique, Lê-Bury, Gabrielle, Lee, Bernett, Lakudzala, Agnes E, Mzinza, David T, Mhango, David V, Mitini-Nkhoma, Steven C, Jambo, Kondwani C, Singhal, Amit, Mwandumba, Henry C, Russell, David G

“…In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter strains with scRNA-seq to simultaneously acquire the host…”
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The COVID-19 pandemic in the African continent by Bwire, Godfrey, Ario, Alex Riolexus, Eyu, Patricia, Ocom, Felix, Wamala, Joseph F, Kusi, Kwadwo A, Ndeketa, Latif, Jambo, Kondwani C, Wanyenze, Rhoda K, Talisuna, Ambrose O

“…In December 2019, a new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and associated disease, coronavirus disease 2019 (COVID-19),…”
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Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state by Mitsi, Elena, Kamng'ona, Raphael, Rylance, Jamie, Solórzano, Carla, Jesus Reiné, J, Mwandumba, Henry C, Ferreira, Daniela M, Jambo, Kondwani C

“…Alveolar macrophages (AM) are critical to the homeostasis of the inflammatory environment in the lung. Differential expression of surface markers classifies…”
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SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021 by Mandolo, Jonathan, Msefula, Jacquline, Henrion, Marc Y R, Brown, Comfort, Moyo, Brewster, Samon, Aubrey, Moyo-Gwete, Thandeka, Makhado, Zanele, Ayres, Frances, Motlou, Thopisang, Mzindle, Nonkululeko, Kalata, Newton, Muula, Adamson S, Kwatra, Gaurav, Nsamala, Natasha, Likaka, Andrew, Mfune, Thom, Moore, Penny L, Mbaya, Bridon, French, Neil, Heyderman, Robert S, Swarthout, Todd, Jambo, Kondwani C

“…By August 2021, the COVID-19 pandemic has been less severe in sub-Saharan Africa than elsewhere. In Malawi, there have been three subsequent epidemic waves. We…”
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Longevity of hybrid immunity against SARS-CoV-2 in adults vaccinated with an adenovirus-based COVID-19 vaccine by Mvula, Memory, Mtonga, Fatima, Mandolo, Jonathan, Jowati, Chisomo, Kalirani, Alice, Chigamba, Precious, Lisimba, Edwin, Mitole, Ndaona, Chibwana, Marah G, Jambo, Kondwani C

“…Hybrid immunity provides better protection against COVID-19 than vaccination or prior natural infection alone. It induces high magnitude and broadly…”
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Acute rotavirus infection is associated with the induction of circulating memory CD4+ T cell subsets by Malamba-Banda, Chikondi, Mhango, Chimwemwe, Benedicto-Matambo, Prisca, Mandolo, Jonathan J., Chinyama, End, Kumwenda, Orpha, Barnes, Kayla G., Cunliffe, Nigel A., Iturriza-Gomara, Miren, Jambo, Kondwani C., Jere, Khuzwayo C.

“…Strong CD4 + T cell-mediated immune protection following rotavirus infection has been observed in animal models, but its relevance in humans remains unclear…”
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Optimal age targeting for pneumococcal vaccination in older adults; a modelling study by Thindwa, Deus, Clifford, Samuel, Kleynhans, Jackie, von Gottberg, Anne, Walaza, Sibongile, Meiring, Susan, Swarthout, Todd D., Miller, Elizabeth, McIntyre, Peter, Andrews, Nick, Amin-Chowdhury, Zahin, Fry, Norman, Jambo, Kondwani C., French, Neil, Almeida, Samanta Cristine Grassi, Ladhani, Shamez N., Heyderman, Robert S., Cohen, Cheryl, de Cunto Brandileone, Maria Cristina, Flasche, Stefan

“…Invasive pneumococcal disease (IPD) risk increases with age for older adults whereas the population size benefiting from pneumococcal vaccines and robustness…”
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AstraZeneca COVID-19 vaccine induces robust broadly cross-reactive antibody responses in Malawian adults previously infected with SARS-CoV-2 by Chibwana, Marah G, Moyo-Gwete, Thandeka, Kwatra, Gaurav, Mandolo, Jonathan, Hermanaus, Tandile, Motlou, Thopisang, Mzindle, Nonkululeko, Ayres, Frances, Chaponda, Mphatso, Tembo, Godwin, Mwenechanya, Percy, Mitole, Ndaona, Jassi, Chisomo, Kamng'ona, Raphael, Afran, Louise, Mzinza, David, Mwandumba, Henry C, Gordon, Stephen B, Jere, Khuzwayo, Madhi, Shabir, Moore, Penny L, Heyderman, Robert S, Jambo, Kondwani C

“…Binding and neutralising anti-Spike antibodies play a key role in immune defence against SARS-CoV-2 infection. Since it is known that antibodies wane with time…”
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TZM-gfp cells: a tractable fluorescent tool for analysis of rare and early HIV-1 infection by Gludish, David W., Boliar, Saikat, Caldwell, Shannon, Tembo, Dumizulu L., Chimbayo, Elizabeth T., Jambo, Kondwani C., Mwandumba, Henry C., Russell, David G.

“…Here we describe TZM-gfp, a novel HIV-1 reporter cell derived from the same parental clone JC.53, used previously to generate the widely-utilized indicator…”
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A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study by Anscombe, Catherine, Lissauer, Samantha, Thole, Herbert, Rylance, Jamie, Dula, Dingase, Menyere, Mavis, Kutambe, Belson, van der Veer, Charlotte, Phiri, Tamara, Banda, Ndaziona P, Mndolo, Kwazizira S, Mponda, Kelvin, Phiri, Chimota, Mallewa, Jane, Nyirenda, Mulinda, Katha, Grace, Mwandumba, Henry, Gordon, Stephen B, Jambo, Kondwani C, Cornick, Jennifer, Feasey, Nicholas, Barnes, Kayla G, Morton, Ben, Ashton, Philip M

“…Compared to the abundance of clinical and genomic information available on patients hospitalised with COVID-19 disease from high-income countries, there is a…”
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Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung by Wright, Adam K A, Bangert, Mathieu, Gritzfeld, Jenna F, Ferreira, Daniela M, Jambo, Kondwani C, Wright, Angela D, Collins, Andrea M, Gordon, Stephen B

“…Pneumococcal carriage is both immunising and a pre-requisite for mucosal and systemic disease. Murine models of pneumococcal colonisation show that…”
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Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents by Mitini-Nkhoma, Steven C., Chimbayo, Elizabeth T., Mzinza, David T., Mhango, David V., Chirambo, Aaron P., Mandalasi, Christine, Lakudzala, Agness E., Tembo, Dumizulu L., Jambo, Kondwani C., Mwandumba, Henry C.

“…Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding…”
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Social mixing patterns relevant to infectious diseases spread by close contact in urban Blantyre, Malawi by Thindwa, Deus, Jambo, Kondwani C., Ojal, John, MacPherson, Peter, Dennis Phiri, Mphatso, Pinsent, Amy, Khundi, McEwen, Chiume, Lingstone, Gallagher, Katherine E., Heyderman, Robert S., Corbett, Elizabeth L., French, Neil, Flasche, Stefan

“…Understanding human mixing patterns relevant to infectious diseases spread through close contact is vital for modelling transmission dynamics and optimisation…”
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Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection by Nyazika, Tinashe K, Sibale, Lusako, Phiri, Joseph, De Ste Croix, Megan, Jasiunaite, Zydrune, Mkandawire, Christopher, Malamba, Rose, Kankwatira, Anstead, Manduwa, Miriam, Ferreira, Daniela M, Nyirenda, Tonney S, Oggioni, Marco R, Mwandumba, Henry C, Jambo, Kondwani C

“…People Living with HIV (PLHIV) are at an increased risk of pneumococcal pneumonia than HIV-uninfected adults, but the reasons for this are still not well…”
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Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage by Wright, Adam K A, Ferreira, Daniela M, Gritzfeld, Jenna F, Wright, Angela D, Armitage, Kathryn, Jambo, Kondwani C, Bate, Emily, El Batrawy, Sherouk, Collins, Andrea, Gordon, Stephen B

“…Infectious challenge of the human nasal mucosa elicits immune responses that determine the fate of the host-bacterial interaction; leading either to clearance,…”
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Airway CD8 + CD161 ++ TCRvα7.2 + T Cell Depletion During Untreated HIV Infection Targets CD103 Expressing Cells by Mvaya, Leonard, Mwale, Andrew, Hummel, Annemarie, Phiri, Joseph, Kamng'ona, Raphael, Mzinza, David, Chimbayo, Elizabeth, Malamba, Rose, Kankwatira, Anstead, Mwandumba, Henry C, Jambo, Kondwani C

“…HIV-infected adults are at an increased risk to lower respiratory tract infections (LRTIs). CD8 CD161 TCRvα7.2 T cells are an innate-like T cell subset that…”
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Functional Analysis of Phagocyte Activity in Whole Blood from HIV/Tuberculosis-Infected Individuals Using a Novel Flow Cytometry-Based Assay by Gupta-Wright, Ankur, Tembo, Dumizulu, Jambo, Kondwani C, Chimbayo, Elizabeth, Mvaya, Leonard, Caldwell, Shannon, Russell, David G, Mwandumba, Henry C

“…The accurate assessment of immune competence through analysis is paramount to our understanding of those immune mechanisms that lead to protection or…”
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Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines by Benedicto-Matambo, Prisca, Bines, Julie E, Malamba-Banda, Chikondi, Shawa, Isaac T, Barnes, Kayla, Kamng'ona, Arox W, Hungerford, Daniel, Jambo, Kondwani C, Iturriza-Gomara, Miren, Cunliffe, Nigel A, Flanagan, Katie L, Jere, Khuzwayo C

“…Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with…”
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The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children by Longwe, Herbert, Jambo, Kondwani C, Phiri, Kamija S, Mbeye, Nyanyiwe, Gondwe, Thandile, Hall, Tom, Tetteh, Kevin K A, Drakeley, Chris, Mandala, Wilson L

“…Co-trimoxazole prophylaxis, currently recommended in HIV-exposed, uninfected (HEU) children as protection against opportunistic infections, also has some…”
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Incomplete recovery of pneumococcal CD4 T cell immunity after initiation of antiretroviral therapy in HIV-infected malawian adults by Sepako, Enoch, Glennie, Sarah J, Jambo, Kondwani C, Mzinza, David, Iwajomo, Oluwadamilola H, Banda, Dominic, van Oosterhout, Joep J, A Williams, Neil, Gordon, Stephen B, Heyderman, Robert S

“…HIV-infected African adults are at a considerably increased risk of life-threatening invasive pneumococcal disease (IPD) which persists despite antiretroviral…”
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