Association between IRS-1, PPAR-γ and LEP genes polymorphisms and growth traits in rabbits

Single nucleotide polymorphisms are commonly associated with changes in quantitative traits, and have been considered useful markers for improving different traits in livestock. The current study aimed to explore the effect of three SNPs located in Insulin receptor substrate (IRS-1), Peroxisome prol...

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Bibliographic Details
Published in:	Animal biotechnology Vol. 34; no. 7; pp. 2391 - 2399
Main Authors:	Helal, Mostafa, Ali, Mahmoud A., Nadrin, Amira H., Awad, Yomna I., Younis, Nada K., Alasyed, Basant M., Jamal, Mohnad, Eid, Dima H., Soliman, Hagar A., Eissa, Sara A., Ragab, Mohamed
Format:	Journal Article
Language:	English
Published:	Abingdon Taylor & Francis 01-12-2023 Taylor & Francis Ltd
Subjects:	Age Body weight Genes Genotypes Growth Growth rate Insulin Insulin receptor substrate 1 IRS-1 IRS-1 gene LEP gene Leptin Livestock Nucleotides Peroxisome proliferator-activated receptors Point mutation polymorphism PPAR-γ Rabbits Receptors Single-nucleotide polymorphism Substrates Weaning Weight New Zealand
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Summary:	Single nucleotide polymorphisms are commonly associated with changes in quantitative traits, and have been considered useful markers for improving different traits in livestock. The current study aimed to explore the effect of three SNPs located in Insulin receptor substrate (IRS-1), Peroxisome proliferator-activated receptor γ (PPAR-γ), and Leptin (LEP) genes on the growth traits of rabbits. Individuals from three rabbit breeds were genotyped using RFLP-PCR. The IRS-1 variant (c.189T > G) was associated with post-weaning body weight, and body weight gains, However, the effect on growth rates was insignificant in Baladi Red and V-line rabbits. The PPAR-γ variant (c.207A > C) was significantly associated with 8-wk body weights in V-line rabbits, 10-wk body weights, and growth rates from 8 to 10 weeks of age in New Zealand rabbits. However, the differences between genotypes were insignificant for body weight gains and average daily gain. The LEP gene mutation (g.16079636C > G) had significant effects on body weights at 6 and 8 weeks of age in New Zealand White rabbits and 8 weeks of age in Baladi Red rabbits were associated with the presence of the C allele. Concludingly, the results stressed the importance of the IRS-1 gene in post-weaning growth and suggested the existence of breed-specific effects for PPAR-γ and LEP.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1049-5398 1532-2378
DOI:	10.1080/10495398.2022.2092743