Selenium and Vitamin E as antioxidants in chronic hemolytic anemia: Are they deficient? A case-control study in a group of Egyptian children

Accelerated oxidative damage is one of the hallmarks in both sickle cell disease (SCD) and thalassemia major (TM). A decreased antioxidant level is found in both diseases. Our study was carried out to evaluate the variation in serum levels of Selenium and Vitamin E among a group of transfusion depen...

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Bibliographic Details
Published in:	Journal of advanced research Vol. 6; no. 6; pp. 1071 - 1077
Main Authors:	Hamdy, Mona M., Mosallam, Dalia S., Jamal, Alaa M., Rabie, Walaa A.
Format:	Journal Article
Language:	English
Published:	Egypt Elsevier B.V 01-11-2015 Elsevier
Subjects:	Antioxidants Egyptian children Original Selenium Sickle cell anemia Vitamin E β-thalassemia Antioxidants Sickle cell anemia Selenium Egyptian children Vitamin E β-thalassemia
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Summary:	Accelerated oxidative damage is one of the hallmarks in both sickle cell disease (SCD) and thalassemia major (TM). A decreased antioxidant level is found in both diseases. Our study was carried out to evaluate the variation in serum levels of Selenium and Vitamin E among a group of transfusion dependant Egyptian SCD and TM patients, further more to correlate these levels with iron overload status or transfusion requirements. A case-control study was conducted at the Cairo University Pediatric Hospital to assess the serum levels of Selenium using Atomic Absorption Spectrometer and Vitamin E using commercially available ELISA Kit in transfusion dependent children, 30 with beta thalassemia and 30 with SCD in a steady state aged from 6 to 18years, these findings were compared to 30age/sex matched healthy controls. Our results revealed a depleted antioxidants level in the studied group of Egyptian children with TM and SCD relative to healthy controls (P<0.05). A significant positive correlation was found between Vitamin E levels and ferritin (r=0.26, p=0.047) in SCD and TM patients. Nonsignificant correlation was detected between serum Selenium and Vitamin E. Moreover, values of these antioxidants did not correlate with indices of hemolysis nor with those of inflammation in chronically transfused TM and SCD patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2090-1232 2090-1224
DOI:	10.1016/j.jare.2015.01.002