Development of Consensus Recommendations on the Management of Vitiligo and the Role of Decapeptide in Vitiligo by the Delphi Method

Treatment of vitiligo is still a challenge in dermatology. Literature is sparse on the definitive clinical role of basic fibroblast growth factor (bFGF) in vitiligo patients. We decided to generate a consensus in an attempt to answer some critical questions related to the management of vitiligo and...

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Bibliographic Details
Published in:	Indian journal of dermatology Vol. 68; no. 5; p. 587
Main Authors:	Parsad, Davinder, Kandhari, Sanjeev, Dhurat, Rachita, Shah, Bela, Majid, Imran, Yadalla, Harikishan Kumar, Sakhiya, Jagdish, Poojary, Shital, Jagadish, P, Banotkar, Pravin D, Babu, Ravindra, Shivakumar, Y M, Bose, S K, Jamadar, Saleem, Shah, Monal, Tank, Bharat, Dhabhai, Ravindra, Mittal, Sanjay Kumar, Bhushan, Premanshu, Pandita, Akshi, Barve, Vaibhav
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-09-2023 Medknow Publications & Media Pvt. Ltd Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications
Subjects:	Analysis bfgf Care and treatment consensus Delphi method Epidemiology Fibroblast growth factors Growth factors Inhibitor drugs Medical treatment Methods Original recommendations Steroids Topical medication Type 2 diabetes Vitiligo India consensus vitiligo Delphi method recommendations bFGF
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Summary:	Treatment of vitiligo is still a challenge in dermatology. Literature is sparse on the definitive clinical role of basic fibroblast growth factor (bFGF) in vitiligo patients. We decided to generate a consensus in an attempt to answer some critical questions related to the management of vitiligo and the role of bFGF. A Delphi method among 21 experts across India was conducted. A consensus (agreement was 75% or greater) was taken on 27 statements on the prevalence, epidemiology, and treatment of vitiligo and the role of bFGF in the management of vitiligo. The consensus process was completed after two rounds. Topical corticosteroid therapy is the first-line therapy for vitiligo; however, its adverse effects are widely known, especially in sensitive areas. Topical calcineurin inhibitors are preferred in stable vitiligo of the face, neck, genitals, or intertriginous regions as an alternative to topical corticosteroids. Topical bFGF is a relatively newer therapy with a promising role in stable vitiligo. bFGF is safe and effective in inducing repigmentation of vitiligo lesions. Combination therapy of bFGF with other topical therapies, phototherapy, and surgical procedures can be beneficial in patients of vitiligo. This consensus would complement the currently available literature on bFGF and help the practitioner to recognize the unmet need in the treatment of vitiligo.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0019-5154 1998-3611
DOI:	10.4103/ijd.ijd_461_23